ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1

Mechanisms of RAS/β-catenin interactions

(2013) Eva Zeller et al.   ARCHIVES OF TOXICOLOGY

ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells

(2013) Y Wang et al.   CELL DEATH AND DIFFERENTIATION

Myeloid Differentiation Factor 88 Promotes Growth and Metastasis of Human Hepatocellular Carcinoma

(2013) B. Liang et al.   CLINICAL CANCER RESEARCH

ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63

(2013) L. Tordella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordinate Direct Input of Both KRAS and IGF1 Receptor to Activation of PI3 kinase in KRAS -Mutant Lung Cancer

(2013) Miriam Molina-Arcas et al.   Cancer Discovery

Loss of the Par3 Polarity Protein Promotes Breast Tumorigenesis and Metastasis

(2012) Luke Martin McCaffrey et al.   CANCER CELL

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Loss of Par3 promotes breast cancer metastasis by compromising cell–cell cohesion

(2012) Bin Xue et al.   NATURE CELL BIOLOGY

Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms

(2012) M E Law et al.   ONCOGENE

N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

(2012) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagic activity dictates the cellular response to oncogenic RAS

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular MRI enables early and sensitive detection of brain metastases

(2012) S. Serres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking epithelial-to-mesenchymal-transition and epigenetic modifications

(2012) Sonja C. Stadler et al.   SEMINARS IN CANCER BIOLOGY

SnapShot: The Epithelial-Mesenchymal Transition

(2011) Jonathan P. Sleeman et al.   CELL

The role of EMT in renal fibrosis

(2011) Rosemarie M. Carew et al.   CELL AND TISSUE RESEARCH

Inhibitory Member of the Apoptosis-stimulating Proteins of the p53 Family (iASPP) Interacts with Protein Phosphatase 1 via a Noncanonical Binding Motif

(2011) Susana Llanos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification

(2011) M. Notari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

(2011) E. Sanchez-Tillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

(2011) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

(2010) Julian Carretero et al.   CANCER CELL

SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence

(2010) X D Wang et al.   CELL DEATH AND DIFFERENTIATION

ASPP2 Regulates Epithelial Cell Polarity through the PAR Complex

(2010) Weili Cong et al.   CURRENT BIOLOGY

ASPP2 Binds Par-3 and Controls the Polarity and Proliferation of Neural Progenitors during CNS Development

(2010) Roberta Sottocornola et al.   DEVELOPMENTAL CELL

Repression of E-cadherin by SNAIL, ZEB1, and TWIST in invasive ductal carcinomas of the breast: a cooperative effort?☆

(2010) Núria Montserrat et al.   HUMAN PATHOLOGY

PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition

(2010) Yvonne L Chao et al.   Molecular Cancer

Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells

(2010) Y Wang et al.   ONCOGENE

Expression Pattern of the ASPP Family Members in Endometrial Endometrioid Adenocarcinoma

(2010) Wen-Kang Liu et al.   ONKOLOGIE

β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling

(2010) Meghan T. Maher et al.   PLoS One

Independent Interactions of Phosphorylated β-Catenin with E-Cadherin at Cell-Cell Contacts and APC at Cell Protrusions

(2010) Maree C. Faux et al.   PLoS One

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

JNK phosphorylates β-catenin and regulates adherens junctions

(2009) Meng-Horng Lee et al.   FASEB JOURNAL

Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma

(2009) Jian Zhao et al.   HEPATOLOGY

The Vascular Basement Membrane as “Soil” in Brain Metastasis

(2009) W. Shawn Carbonell et al.   PLoS One

The role of the ZEB family of transcription factors in development and disease

(2008) C. Vandewalle et al.   CELLULAR AND MOLECULAR LIFE SCIENCES