Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes

Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity

(2017) Justin M. Lopchuk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical Multicomponent Carboamination of [1.1.1]Propellane

(2017) Junichiro Kanazawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward Resolving the Resveratrol Conundrum: Synthesis and in Vivo Pharmacokinetic Evaluation of BCP–Resveratrol

(2017) Yi Ling Goh et al.   ACS Medicinal Chemistry Letters

Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group

(2017) Pierrik Lassalas et al.   ACS Medicinal Chemistry Letters

Design, Synthesis, and Application of an Optimized Monofluorinated Aliphatic Label for Peptide Studies by Solid-State 19 F NMR Spectroscopy

(2016) Serhii O. Kokhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

(2016) Benjamin A. Chalmers et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space

(2016) Nicholas A. Meanwell   CHEMICAL RESEARCH IN TOXICOLOGY

Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry

(2016) James A. Bull et al.   CHEMICAL REVIEWS

Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins

(2016) K. C. Nicolaou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding Initiation with Triethylboron and Oxygen: The Differences between Low-Oxygen and High-Oxygen Regimes

(2016) Dennis P. Curran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2′-Alkynylnucleotides: A Sequence- and Spin Label-Flexible Strategy for EPR Spectroscopy in DNA

(2016) Marius M. Haugland et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A practical metal-free homolytic aromatic alkylation protocol for the synthesis of 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid

(2016) Navanita T. Thirumoorthi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Strain-release amination

(2016) R. Gianatassio et al.   SCIENCE

Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor

(2016) Nicholas D. Measom et al.   ACS Medicinal Chemistry Letters

Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene

(2015) Navanita T. Thirumoorthi et al.   CHEMICAL COMMUNICATIONS

Evaluation oftert-Butyl Isosteres: Case Studies of Physicochemical and Pharmacokinetic Properties, Efficacies, and Activities

(2015) Matthias V. Westphal et al.   ChemMedChem

Radical fluorination powered expedient synthesis of 3-fluorobicyclo[1.1.1]pentan-1-amine

(2015) Yi Ling Goh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A New Route to Bicyclo[1.1.1]pentan-1-amine from 1-Azido-3-iodobicyclo[1.1.1]pentane

(2014) Yi Ling Goh et al.   ORGANIC LETTERS

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

(2012) Antonia F. Stepan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Scalable Synthesis of 1-Bicyclo[1.1.1]pentylamine via a Hydrohydrazination Reaction

(2011) Kevin D. Bunker et al.   ORGANIC LETTERS

CRYSTALSenhancements: dealing with hydrogen atoms in refinement

(2010) Richard I. Cooper et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY