A practical metal-free homolytic aromatic alkylation protocol for the synthesis of 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid

Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

(2016) Benjamin A. Chalmers et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Redox-Active Esters in Fe-Catalyzed C–C Coupling

(2016) Fumihiko Toriyama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strain-release amination

(2016) R. Gianatassio et al.   SCIENCE

Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene

(2015) Navanita T. Thirumoorthi et al.   CHEMICAL COMMUNICATIONS

Radical fluorination powered expedient synthesis of 3-fluorobicyclo[1.1.1]pentan-1-amine

(2015) Yi Ling Goh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design, Synthesis, and Characterization of SO2-Containing Azabicyclo[3.n.1]alkanes: Promising Building Blocks for Drug Discovery

(2015) Tetiana Druzhenko et al.   ORGANIC LETTERS

Late-Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis

(2014) Daniel A. DiRocco et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New Route to Bicyclo[1.1.1]pentan-1-amine from 1-Azido-3-iodobicyclo[1.1.1]pentane

(2014) Yi Ling Goh et al.   ORGANIC LETTERS

Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

(2014) Joanna Wlochal et al.   ORGANIC LETTERS

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

(2012) Antonia F. Stepan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorine Transfer to Alkyl Radicals

(2012) Montserrat Rueda-Becerril et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Catalyzed Decarboxylative Fluorination of Aliphatic Carboxylic Acids in Aqueous Solution

(2012) Feng Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Scalable Synthesis of 1-Bicyclo[1.1.1]pentylamine via a Hydrohydrazination Reaction

(2011) Kevin D. Bunker et al.   ORGANIC LETTERS

Minisci reactions: Versatile CH-functionalizations for medicinal chemists

(2011) Matthew A. J. Duncton   MedChemComm

Oxetanes as Versatile Elements in Drug Discovery and Synthesis

(2010) Johannes A. Burkhard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

(2010) Kevin W. Gillman et al.   ACS Medicinal Chemistry Letters

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY