Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene

Free Radical-mediated Hydroxymethylation Using CO and HCHO

(2014) Takuji Kawamoto et al.   CHIMIA

Borohydride-Mediated Radical Addition Reactions of Organic Iodides to Electron-Deficient Alkenes

(2014) Takuji Kawamoto et al.   JOURNAL OF ORGANIC CHEMISTRY

Cyanoborohydride-Promoted Radical Arylation of Benzene

(2014) Takuji Kawamoto et al.   ORGANIC LETTERS

A New Route to Bicyclo[1.1.1]pentan-1-amine from 1-Azido-3-iodobicyclo[1.1.1]pentane

(2014) Yi Ling Goh et al.   ORGANIC LETTERS

Flow Giese reaction using cyanoborohydride as a radical mediator

(2013) Takahide Fukuyama et al.   Beilstein Journal of Organic Chemistry

Efficient Hydroxymethylation Reactions of Iodoarenes Using CO and 1,3-Dimethylimidazol-2-ylidene Borane

(2013) Takuji Kawamoto et al.   ORGANIC LETTERS

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

(2012) Antonia F. Stepan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Radical Addition of Alkyl Halides to Formaldehyde in the Presence of Cyanoborohydride as a Radical Mediator. A New Protocol for Hydroxymethylation Reaction

(2011) Takuji Kawamoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Minisci reactions: Versatile CH-functionalizations for medicinal chemists

(2011) Matthew A. J. Duncton   MedChemComm

Black-Light-Induced Radical/Ionic Hydroxymethylation of Alkyl Iodides with Atmospheric CO in the Presence of Tetrabutylammonium Borohydride

(2010) Shoji Kobayashi et al.   ORGANIC LETTERS

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

(2010) Kevin W. Gillman et al.   ACS Medicinal Chemistry Letters

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Tin-Free Giese Reaction and the Related Radical Carbonylation Using Alkyl Iodides and Cyanoborohydrides

(2008) Ilhyong Ryu et al.   ORGANIC LETTERS