Article
Biochemistry & Molecular Biology
Hongyu Xiao, Hailun Li, Yifan Wen, Dongxu Jiang, Shumin Zhu, Xueling He, Qingping Xiong, Jie Gao, Shaozhen Hou, Song Huang, Lian He, Jian Liang
Summary: TFP shows significant therapeutic effects on DSS-induced UC model by inhibiting inflammation and restoring intestinal barrier and mucus barrier function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Yaxing Li, Guanping Zhan, Min Tu, Yuhua Wang, Jixuan Cao, Shujing Sun
Summary: In this study, a high-quality chromosome-scale genome of Tremella fuciformis was reported using Pacbio HiFi sequencing combining Hi-C technology. The genome size was 27.38 Mb, organized into 10 chromosomes, with a contig N50 of 2.28 Mb, GC content of 56.51%, BUSCOs completeness of 93.1%, and consensus quality value of 33.7. Additionally, the proteome of T. fuciformis was identified, and 24 genes related to T. fuciformis polysaccharides biosynthesis were discovered in mycelia. This study provides valuable genomic and proteomic information for further biological and genetic studies in T. fuciformis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Ben Niu, Simin Feng, Shuangqing Xuan, Ping Shao
Summary: The study found that using maltodextrin as wall materials can reduce moisture adsorption and caking strength of Tremella fuciformis polysaccharides (TPs) microcapsules powder. The administration of TPs microcapsules powder showed hypoglycemic effects and molecular mechanisms related to regulating the PI3K/Akt pathway, leading to decreased blood glucose levels and improved lipid profiles.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Furong Hou, Shuhui Yang, Xiaobin Ma, Zhiqing Gong, Yansheng Wang, Wenliang Wang
Summary: In this study, emulsions stabilized by Tremella fuciformis polysaccharides (TFP) were prepared and evaluated. The TFP emulsions exhibited excellent emulsifying activity and stability, as well as good storage and freeze-thaw stability. The rheological properties of TFP emulsions showed higher viscosity and tendency to form a more stable network structure. Additionally, the O-H bond could be destructed during the emulsion preparation without the formation of new covalent bonds.
Review
Dermatology
Jessica Mineroff, Jared Jagdeo
Summary: Tremella fuciformis, also known as snow mushroom, is an edible mushroom widely used in herbal and Asian medicine and cuisine. Its polysaccharide ingredients have shown positive effects in antioxidation, antitumor, antidiabetic, immunomodulatory, and neuroprotective pathways. However, further clinical research is needed to understand its role in dermatology.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Lingna Xie, Kaiye Yang, Yiheng Liang, Zhenyuan Zhu, Zhengqiang Yuan, Zhiyun Du
Summary: Tremella fuciformis polysaccharides (TFPS) have therapeutic effects on atopic dermatitis (AD), with oral administration showing better efficacy than topical application. TFPS treatment increases the proportion of regulatory T cells and modulates the composition of gut microbiota.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Jiaqi Shang, Yang Liu, Jiaxin Kang, Shen Yang, Ritian Jin
Summary: This study demonstrated that TFP-WPI nanoparticles can serve as carriers for CUR, with good stability and sustained release properties.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Food Science & Technology
Lei Gao, Yifei Wang, Fan Zhang, Shiji Li, Jiaqi Zhao, Qing Zhang, Jingrun Ye, Yan Ma, Zhipeng Wang, Wei Chen
Summary: In this study, the problems of poor reproducibilities and large measurement errors in the widely used colorimetric method based on the phenol-sulfuric acid system were addressed through a systematic investigation. The influences of various factors on TFPS determination were intensively studied and optimized, and the accurate quantification of TFPS in the presence of enzyme interference was innovatively realized. This study not only provides a theoretical basis for accurate detection and quantification of TFPS, but also offers insights for standardization and utilization of other types of polysaccharides.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Ding-Tao Wu, Ling-Yan An, Wen Liu, Yi-Chen Hu, Sheng-Peng Wang, Liang Zou
Summary: The polysaccharides from Tremella fuciformis show stability under simulated digestion conditions, but are significantly utilized by intestinal microbiota in human feces after in vitro fermentation, potentially improving intestinal health.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Immunology
Yingyin Xu, Liyuan Xie, Zhiyuan Zhang, Weiwei Zhang, Jie Tang, Xiaolan He, Jie Zhou, Weihong Peng
Summary: This study identified the protective effects of Tremella fuciformis polysaccharides (TPs) against colitis in mice, demonstrating that TPs could alleviate inflammation by modulating immune responses and restoring gut microbiota and microbial metabolites.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lingna Xie, Guangrong Liu, Zebin Huang, Zhenyuan Zhu, Kaiye Yang, Yiheng Liang, Yani Xu, Lanyue Zhang, Zhiyun Du
Summary: The potential anti-tumor mechanism of Tremella fuciformis polysaccharides (TFPS) was explored using an in vitro co-culture system. TFPS did not inhibit the cell viability of B16 melanoma cells, but induced significant apoptosis when co-cultured with TFPS-treated RAW264.7 cells. TFPS-treated RAW264.7 cells showed upregulation of M1 macrophage markers and enhanced migration, phagocytosis, production of inflammatory mediators, and protein expression. Network pharmacology analysis suggested the involvement of MAPK and NF-kappa B signaling pathways in M1 polarization, which was verified by Western blot.
Article
Chemistry, Applied
Xiaodan Shi, Jiawen Feng, Shaoyun Wang, Jingjing Huang, Manling Yu
Summary: In this study, the polysaccharide compositions of T. fuciformis fruiting body were analyzed and characterized. Significant differences were observed in the chemical compositions, structural aspects, physicochemical properties, and functional properties of the four extracts. The findings provide theoretical support for the application of tremella polysaccharides in the fields of food, medicine, and cosmetics.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Food Science & Technology
Caiyuan Yu, Yan Fang, Weiwei Huang, Peng Lei, Xiaoqi Xu, Dafeng Sun, Lingtian Wu, Hong Xu, Sha Li
Summary: This study investigated the promoting effect of Span 80 on substrate transfer and TFPS production. The results showed that the addition of 0.3% Span 80 significantly increased the yield of TFPS. Span 80 improved the permeability of cell membrane, facilitated TFPS secretion, and enhanced its antioxidant activity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tariq Jamal Khan, Xiaofei Xu, Xiaoling Xie, Ximing Dai, Pingnan Sun, Qingdong Xie, Xiaoling Zhou
Summary: TFCP prevents the progression of NAFLD by inhibiting oxidative stress and inflammation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Dermatology
Hao Fu, ShiQuan You, Dan Zhao, Quan An, Jiachan Zhang, Changtao Wang, Dongdong Wang, Meng Li
Summary: This study reveals the protective effect of Tremella fuciformis polysaccharides (TFPS) on UVA-induced oxidative stress in skin fibroblasts, potentially through regulating antioxidant enzyme activities and modulating the Nrf2-Keap1 pathway. TFPS pretreatment effectively alleviates skin damage caused by UVA through upregulating Nrf2 and downregulating Keap1 expression, and increasing collagen I, elastin, and hyaluronic acid in fibroblasts treated with UVA.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Neurosciences
Kaiyi Zhu, Xing Zhu, Shenghui Sun, Wei Yang, Shiqi Liu, Zhen Tang, Rong Zhang, Jian Li, Tao Shen, Mingyan Hei
Summary: In this study, it was found that TLR4 activation induced neuronal ferroptosis following hypoxic-ischemic brain damage (HIBD), and inhibition of TLR4 attenuated oxidative stress-induced damage, decreased the activation of ferroptosis, and attenuated neuroinflammation following HIBD, thereby exerting neuroprotective effects. The results demonstrated that the inhibition of TLR4-p38 MAPK signaling modulates HIBD- or OGD-induced ferroptosis in neuronal cells and may play a novel role in brain homeostasis.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Linfang Li, Xiaoyi Zhang, Hangjiang Ren, Xiuqing Huang, Tao Shen, Weiqing Tang, Lin Dou, Jian Li
Summary: miR-23a/b-3p enhances the stability of Srebp-1c and Fas mRNA by binding to their 5'-UTR, promoting triglyceride accumulation in hepatocytes.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2022)
Article
Cell Biology
Mingjing Yan, Yuan Cao, Que Wang, Kun Xu, Lin Dou, Xiuqing Huang, Beidong Chen, Weiqing Tang, Ming Lan, Bing Liu, Kaiyi Zhu, Yao Yang, Shenghui Sun, Xiyue Zhang, Yong Man, Mingyan Hei, Tao Shen, Jian Li
Summary: miR-488-3p exerts protective effects in doxorubicin-induced cardiotoxicity by inhibiting the expression of CyclinG1.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyi Zhang, Tong An, Xiyue Zhang, Tao Shen, Hongxia Li, Lin Dou, Xiuqing Huang, Yong Man, Weiqing Tang, Jian Li
Summary: DDX17 overexpression inhibits lipid accumulation in hepatic cells induced by oleic acid/palmitic acid, possibly through inhibition of de novo fatty acid synthesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Oncology
Kun Xu, Shenghui Sun, Mingjing Yan, Ju Cui, Yao Yang, Wenlin Li, Xiuqing Huang, Lin Dou, Beidong Chen, Weiqing Tang, Ming Lan, Jian Li, Tao Shen
Summary: DEAD-box (DDX)5 and DDX17, members of the DEAD-box RNA helicase family, are shuttle proteins that can move between the nucleus and cytoplasm. They participate in various RNA metabolism processes and play important roles in tumorigenesis and tumor progression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shenghui Sun, Kun Xu, Mingjing Yan, Ju Cui, Kaiyi Zhu, Yao Yang, Xiaoyi Zhang, Weiqing Tang, Xiuqing Huang, Lin Dou, Beidong Chen, Yajun Lin, Xiyue Zhang, Yong Man, Jian Li, Tao Shen
Summary: This study investigates the function and regulatory mechanisms of delphinidin in the treatment of hepatocellular carcinoma. The results show that delphinidin has a strong anti-tumor effect by inducing tumor cell autophagic flux blockage and apoptosis, and inhibiting the expression of multidrug resistance gene 1 and tumour-promoting transcription cofactor DEAD-box helicase 17.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Review
Cell Biology
Yuan-Yuan Liu, Da Huo, Lv-Tao Zeng, Guo-Qing Fan, Tao Shen, Tie-Mei Zhang, Jian-Ping Cai, Ju Cui
Summary: This review provides insights into the structure, function, and mechanisms of mesencephalic astrocyte-derived neurotrophic factor (MANF), highlighting its neuroprotective and cell-protective effects in various diseases and aging.
AGEING RESEARCH REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Kun Xu, Yao Yang, Ming Lan, Jiannan Wang, Bing Liu, Mingjing Yan, Hua Wang, Wenlin Li, Shenghui Sun, Kaiyi Zhu, Xiyue Zhang, Mingyan Hei, Xiuqing Huang, Lin Dou, Weiqing Tang, Qing He, Jian Li, Tao Shen
Summary: Apigenin, a natural flavonoid found in vegetables and fruits, has protective effects on oxidative stress-induced myocardial injury by modulating the SIRT1 signaling pathway, which suggests its potential as a therapeutic compound for cardiovascular diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biophysics
Tong An, Xiaoyi Zhang, Xin Gao, Xiyue Zhang, Tao Shen, Hongxia Li, Lin Dou, Xiuqing Huang, Yong Man, Guoping Li, Weiqing Tang, Jian Li
Summary: Endothelial dysfunction plays a crucial role in the development of atherosclerosis, and this dysfunction is caused by the accumulation of senescent vascular endothelial cells. Phosphoenolpyruvate (PEP), a high-energy glycolytic intermediate, has protective effects against ischemia-reperfusion injury in various tissues. However, serum PEP levels are significantly higher in healthy elderly individuals compared to young individuals. The effect of circulating PEP on endothelial cell function remains unclear. This study found that PEP promoted monocyte adhesion to endothelial cells and decreased the expression of nitric oxide synthase, leading to endothelial dysfunction and senescence.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2023)
Article
Endocrinology & Metabolism
Da Huo, Yuan-Yuan Liu, Chi Zhang, Lv-Tao Zeng, Guo-Qing Fan, Li-Qun Zhang, Jing Pang, Yao Wang, Tao Shen, Xue-Fei Li, Chuan-Bao Li, Tie-Mei Zhang, Jian-Ping Cai, Ju Cui
Summary: This study investigated the potential of serum glycoprotein non-metastatic melanoma protein B (GPNMB) as a biomarker for diabetes mellitus (DM) and DM-associated cataract. The results showed that serum GPNMB levels were higher in diabetic individuals and subjects with cataract, and were correlated with DM and cataract. Furthermore, serum GPNMB levels had diagnostic value for DM-associated cataract.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Xiuqing Huang, Xiansheng Luo, Mingjing Yan, Hao Chen, Huiyan Zuo, Kun Xu, Jiarui Ma, Lin Dou, Tao Shen, Mu-Hua Huang
Summary: This study successfully synthesized C2N-120 nanoparticles through an improved method and evaluated their toxicity and biocompatibility compared to GO nanoparticles. The results demonstrated that C2N-120 exhibited higher biocompatibility and lower cytotoxicity in vivo and in vitro, indicating its potential for biomedical applications in the future.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Biochemistry & Molecular Biology
Kaiyi Zhu, Xing Zhu, Jie Yu, Lu Chen, Shiqi Liu, Mingjing Yan, Wei Yang, Yanyan Sun, Zhe Zhang, Jian Li, Tao Shen, Mingyan Hei
Summary: Microglial pyroptosis mediated by HMGB1/RAGE/cat B signaling pathway plays a crucial role in neonatal hypoxic-ischemic brain damage, regulating inflammation and neuronal injury, affecting learning and memory function.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Min Mao, Yalan Deng, Li Wang, Gexin Zhao, Ruomei Qi, Huan Gong, Tao Shen, Yitian Xu, Deping Liu, Beidong Chen
Summary: Chronic unpredictable mild stress (CUMS) exacerbates atherosclerosis by inducing the hypertrophy and dysfunction of white adipocytes.
Article
Medicine, General & Internal
Yao Yang, Zhiqiang Sun, Zhenping Li, Que Wang, Mingjing Yan, Wenlin Li, Kun Xu, Tao Shen
Summary: By analyzing gene expression data related to age-related macular degeneration (AMD), this study identified six genes closely associated with Tfh cells. After further screening, GABRB3, MFF, and PROX1 were selected as potential diagnostic biomarkers for AMD.
Review
Biochemistry & Molecular Biology
Jun Guo, Xiuqing Huang, Lin Dou, Mingjing Yan, Tao Shen, Weiqing Tang, Jian Li
Summary: Aging is an irreversible pathophysiological process that results in declines in tissue and cell functions and increased risks of aging-related diseases. Current research focuses on understanding how various stresses contribute to aging and identifying interventions and treatments to promote healthy aging and longevity.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)