All-Round Manipulation of the Actin Cytoskeleton by HIV

Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover

(2017) M. Angeles Juanes et al.   JOURNAL OF CELL BIOLOGY

Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport

(2017) Michael Keegan Delaney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells

(2017) Mark B. Lucera et al.   Retrovirology

HIV infection is influenced by dynamin at 3 independent points in the viral life cycle

(2017) Anupriya Aggarwal et al.   TRAFFIC

The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein

(2017) Kei Miyakawa et al.   Nature Communications

Tat is a multifunctional viral protein that modulates cellular gene expression and functions

(2017) Evan Clark et al.   Oncotarget

HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread

(2017) Alice C.L. Len et al.   Cell Reports

Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells

(2017) Jason A. Neidleman et al.   PLoS Pathogens

Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells

(2016) Mickaël M. Ménager et al.   CELL

Statins for Prevention of Cardiovascular Disease in Adults

(2016) Roger Chou et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cellular functions of the ADF/cofilin family at a glance

(2016) Georgios Kanellos et al.   JOURNAL OF CELL SCIENCE

Cardiovascular Disease, Statins, and HIV

(2016) Allison Ross Eckard et al.   JOURNAL OF INFECTIOUS DISEASES

Monocytes but Not Lymphocytes Carrying HIV-1 on Their Surface Transmit Infection to Human Tissue Ex Vivo

(2016) Victor Barreto-de-Souza et al.   JOURNAL OF VIROLOGY

LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse

(2016) Shimona Starling et al.   JOURNAL OF VIROLOGY

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection

(2016) Kenneth M. Law et al.   Cell Reports

Specification of Architecture and Function of Actin Structures by Actin Nucleation Factors

(2015) Colleen T. Skau et al.   Annual Review of Biophysics

The Contribution of Extracellular Nef to HIV-Induced Pathogenesis

(2015) Eleonora Olivetta et al.   CURRENT DRUG TARGETS

HIV-1 Cell-to-Cell Transmission and Antiviral Strategies: An Overview

(2015) Nicoletta Casartelli   CURRENT DRUG TARGETS

Hck Inhibitors as Potential Therapeutic Agents in Cancer and HIV Infection

(2015) F. Musumeci et al.   CURRENT MEDICINAL CHEMISTRY

Rac1 is correlated with aggressiveness and a potential therapeutic target for gastric cancer

(2015) JUN JI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Involvement of the Rac1-IRSp53-Wave2-Arp2/3 Signaling Pathway in HIV-1 Gag Particle Release in CD4 T Cells

(2015) Audrey Thomas et al.   JOURNAL OF VIROLOGY

Analysis of HIV-1 Gag Protein Interactions via Biotin Ligase Tagging

(2015) Christopher Ritchie et al.   JOURNAL OF VIROLOGY

Investigation of the HIV-1 matrix interactome during virus replication

(2015) Yan Li et al.   Proteomics Clinical Applications

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection

(2015) X. Sewald et al.   SCIENCE

CDC42 Use in Viral Cell Entry Processes by RNA Viruses

(2015) Thomas Swaine et al.   Viruses-Basel

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex

(2015) Andrea Imle et al.   mBio

HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup

(2015) Solène Debaisieux et al.   Nature Communications

Vav1: A Dr. Jekyll and Mr. Hyde protein – good for the hematopoietic system, bad for cancer

(2015) Shulamit Katzav   Oncotarget

Slit2N Inhibits Transmission of HIV-1 from Dendritic Cells to T-cells by Modulating Novel Cytoskeletal Elements

(2015) Ashutosh Shrivastava et al.   Scientific Reports

Hybrid Spreading Mechanisms and T Cell Activation Shape the Dynamics of HIV-1 Infection

(2015) Changwang Zhang et al.   PLoS Computational Biology

Efficient transfer of HIV-1 in trans and in cis from Langerhans dendritic cells and macrophages to autologous T lymphocytes

(2014) Maryse Peressin et al.   AIDS

The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure

(2014) Jennifer H. Campbell et al.   AIDS

Bacterial subversion of host cytoskeletal machinery: Hijacking formins and the Arp2/3 complex

(2014) Dorothy Truong et al.   BIOESSAYS

HIV-1 reprograms the migration of macrophages

(2014) C. Verollet et al.   BLOOD

Rac-1 as a New Therapeutic Target in Cerebro- and Cardio-Vascular Diseases

(2014) Albino Carrizzo et al.   CURRENT DRUG TARGETS

Novel anti-HIV therapeutics targeting chemokine receptors and actin regulatory pathways

(2014) Mark Spear et al.   IMMUNOLOGICAL REVIEWS

HIV-1 Triggers WAVE2 Phosphorylation in Primary CD4 T Cells and Macrophages, Mediating Arp2/3-dependent Nuclear Migration

(2014) Mark Spear et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment

(2014) John Jeff Alvarado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Basic Domain of HIV-Tat Transactivating Protein Is Essential for Its Targeting to Lipid Rafts and Regulating Fibroblast Growth Factor-2 Signaling in Podocytes Isolated from Children with HIV-1-Associated Nephropathy

(2014) X. Xie et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Investigating the Role of F-Actin in Human Immunodeficiency Virus Assembly by Live-Cell Microscopy

(2014) Sheikh Abdul Rahman et al.   JOURNAL OF VIROLOGY

The Nucleocapsid Domain of Gag Is Dispensable for Actin Incorporation into HIV-1 and for Association of Viral Budding Sites with Cortical F-Actin

(2014) Sarah Stauffer et al.   JOURNAL OF VIROLOGY

ROCK1 and LIM Kinase Modulate Retrovirus Particle Release and Cell-Cell Transmission Events

(2014) X. Wen et al.   JOURNAL OF VIROLOGY

Ezrin Is a Component of the HIV-1 Virological Presynapse and Contributes to the Inhibition of Cell-Cell Fusion

(2014) N. H. Roy et al.   JOURNAL OF VIROLOGY

Contact-Induced Mitochondrial Polarization Supports HIV-1 Virological Synapse Formation

(2014) Elisabetta Groppelli et al.   JOURNAL OF VIROLOGY

Three-Dimensional Imaging of HIV-1 Virological Synapses Reveals Membrane Architectures Involved in Virus Transmission

(2014) T. Do et al.   JOURNAL OF VIROLOGY

Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins

(2014) Erinn S. Raborn et al.   LIFE SCIENCES

Adding new dimensions: towards an integrative understanding of HIV-1 spread

(2014) Oliver T. Fackler et al.   NATURE REVIEWS MICROBIOLOGY

HIV-1 induces cytoskeletal alterations and Rac1 activation during monocyte-blood–brain barrier interactions: modulatory role of CCR5

(2014) Shawna M Woollard et al.   Retrovirology

The Immunological Synapse

(2014) M. L. Dustin   Cancer Immunology Research

Viral exploitation of actin: force-generation and scaffolding functions in viral infection

(2014) Mark Spear et al.   VIROLOGICA SINICA

High multiplicity HIV-1 cell-to-cell transmission from macrophages to CD4+ T cells limits antiretroviral efficacy

(2013) Christopher J.A. Duncan et al.   AIDS

APC Polymorphisms and the Risk of Colorectal Neoplasia: A HuGE Review and Meta-Analysis

(2013) Jing Liang et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

T cell antigen receptor activation and actin cytoskeleton remodeling

(2013) Sudha Kumari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Arp2/3-Mediated Actin-Based Motility: A Tail of Pathogen Abuse

(2013) Matthew D. Welch et al.   Cell Host & Microbe

Small Rho GTPases in the control of cell shape and mobility

(2013) Arun Murali et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HIV-1 Nef Mediates Pak Phosphorylation of Mek1 Serine298 and Elicits an Active Phospho-state of Pak2

(2013) Arlette Kouwenhoven et al.   CURRENT HIV RESEARCH

Architecture and host interface of environmental chlamydiae revealed by electron cryotomography

(2013) Martin Pilhofer et al.   ENVIRONMENTAL MICROBIOLOGY

The Conserved Set of Host Proteins Incorporated into HIV-1 Virions Suggests a Common Egress Pathway in Multiple Cell Types

(2013) Michael E. Linde et al.   JOURNAL OF PROTEOME RESEARCH

Efficiency of Cell-Free and Cell-Associated Virus in Mucosal Transmission of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

(2013) D. Kolodkin-Gal et al.   JOURNAL OF VIROLOGY

RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis

(2013) H. K. Bid et al.   MOLECULAR CANCER THERAPEUTICS

Gelsolin activity controls efficient early HIV-1 infection

(2013) Laura García-Expósito et al.   Retrovirology

Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen

(2013) Ronald P Trible et al.   Retrovirology

The infectious synapse formed between mature dendritic cells and CD4+ T cells is independent of the presence of the HIV-1 envelope glycoprotein

(2013) Maria T Rodriguez-Plata et al.   Retrovirology

Molecular signatures of T-cell inhibition in HIV-1 infection

(2013) Marie Larsson et al.   Retrovirology

HIV-1 Infection of T Cells and Macrophages Are Differentially Modulated by Virion-Associated Hck: A Nef-Dependent Phenomenon

(2013) Alyssa Cornall et al.   Viruses-Basel

HIV-1 Nef: a multifaceted modulator of T cell receptor signaling

(2012) Libin Abraham et al.   Cell Communication and Signaling

Nef interaction with actin compromises human podocyte actin cytoskeletal integrity

(2012) Raymond Tan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Cell surface dynamics - how Rho GTPases orchestrate the interplay between the plasma membrane and the cortical cytoskeleton

(2012) I. de Curtis et al.   JOURNAL OF CELL SCIENCE

New insights into the regulation and cellular functions of the ARP2/3 complex

(2012) Jeremy D. Rotty et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Slit2N/Robo1 Inhibit HIV-gp120-Induced Migration and Podosome Formation in Immature Dendritic Cells by Sequestering LSP1 and WASp

(2012) Anil Prasad et al.   PLoS One

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo

(2012) B. Stolp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The trinity of the cortical actin in the initiation of HIV-1 infection

(2012) Mark Spear et al.   Retrovirology

Rocket Launcher Mechanism of Collaborative Actin Assembly Defined by Single-Molecule Imaging

(2012) D. Breitsprecher et al.   SCIENCE

Virus assembly and plasma membrane domains: Which came first?

(2012) A. Kerviel et al.   VIRUS RESEARCH

Mobilization of HIV Spread by Diaphanous 2 Dependent Filopodia in Infected Dendritic Cells

(2012) Anupriya Aggarwal et al.   PLoS Pathogens

Knockdown of ERM Family Member Moesin in Host Cells Increases HIV Type 1 Replication

(2011) Gianni Capalbo et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation

(2011) D. S. Nikolic et al.   BLOOD

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

(2011) X. Pan et al.   BLOOD

LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes

(2011) Mohammad Ishaq et al.   BMC MOLECULAR BIOLOGY

Interactions of the HIV/SIV Pathogenicity Factor Nef with SH3 Domain-Containing Host Cell Proteins

(2011) Kalle Saksela   CURRENT HIV RESEARCH

LIM Kinase 1 Modulates Cortical Actin and CXCR4 Cycling and Is Activated by HIV-1 to Initiate Viral Infection

(2011) Paul J. Vorster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Filamin A Protein Interacts with Human Immunodeficiency Virus Type 1 Gag Protein and Contributes to Productive Particle Assembly

(2011) JoAnn Cooper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Particle Tracking Confirms That Multivalent Tat Protein Transduction Domain-induced Heparan Sulfate Proteoglycan Cross-linkage Activates Rac1 for Internalization

(2011) Junji Imamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Focal Adhesion Proteins Talin-1 and Vinculin Negatively Affect Paxillin Phosphorylation and Limit Retroviral Infection

(2011) Craig Brown et al.   JOURNAL OF MOLECULAR BIOLOGY

Spinoculation Triggers Dynamic Actin and Cofilin Activity That Facilitates HIV-1 Infection of Transformed and Resting CD4 T Cells

(2011) J. Guo et al.   JOURNAL OF VIROLOGY

Subversion of the actin cytoskeleton during viral infection

(2011) Matthew P. Taylor et al.   NATURE REVIEWS MICROBIOLOGY

HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA)

(2011) Catarina E. Hioe et al.   PLoS One

Urokinase Plasminogen Activator Inhibits HIV Virion Release from Macrophage-Differentiated Chronically Infected Cells via Activation of RhoA and PKCε

(2011) Francesca Graziano et al.   PLoS One

The Ins and Outs of HIV-1 Tat

(2011) Solène Debaisieux et al.   TRAFFIC

How HIV-1 Takes Advantage of the Cytoskeleton during Replication and Cell-to-Cell Transmission

(2011) Martin Lehmann et al.   Viruses-Basel

How HIV Takes Advantage of the Cytoskeleton in Entry and Replication

(2011) Bettina Stolp et al.   Viruses-Basel

The filamins

(2011) Fumihiko Nakamura et al.   Cell Adhesion & Migration

The Regulated Secretory Pathway in CD4+ T cells Contributes to Human Immunodeficiency Virus Type-1 Cell-to-Cell Spread at the Virological Synapse

(2011) Clare Jolly et al.   PLoS Pathogens

C-type lectin DC-SIGN: An adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity

(2010) Urban Švajger et al.   CELLULAR SIGNALLING

New mechanisms and functions of actin nucleation

(2010) Elif Nur Firat-Karalar et al.   CURRENT OPINION IN CELL BIOLOGY

Nef does not inhibit F-actin remodelling and HIV-1 cell–cell transmission at the T lymphocyte virological synapse

(2010) Claudia Haller et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1

(2010) Kyoko Okada et al.   JOURNAL OF CELL BIOLOGY

Infection of Macaques after Vaginal Exposure to Cell‐Associated Simian Immunodeficiency Virus

(2010) Bettina Sallé et al.   JOURNAL OF INFECTIOUS DISEASES

Lentiviral Nef Proteins Utilize PAK2-Mediated Deregulation of Cofilin as a General Strategy To Interfere with Actin Remodeling

(2010) B. Stolp et al.   JOURNAL OF VIROLOGY

Virus Cell-to-Cell Transmission

(2010) W. Mothes et al.   JOURNAL OF VIROLOGY

Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans–T cell conjugates

(2010) Y Ganor et al.   Mucosal Immunology

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon

(2010) M. R. Lopez-Huertas et al.   NUCLEIC ACIDS RESEARCH

Rac Activation by the T-Cell Receptor Inhibits T Cell Migration

(2010) Eva Cernuda-Morollón et al.   PLoS One

3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells

(2010) R. L. Felts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton

(2010) P. U. Cameron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis of PBMCs: characterization of potential HIV-associated proteins

(2010) Lijun Zhang et al.   Proteome Science

ADF/Cofilin: a functional node in cell biology

(2010) Barbara W. Bernstein et al.   TRENDS IN CELL BIOLOGY

T Cell Polarization at the Virological Synapse

(2010) Clare Jolly   Viruses-Basel

Dendritic Cells and HIV-1 Trans-Infection

(2010) David McDonald   Viruses-Basel

Cryo Electron Tomography of Native HIV-1 Budding Sites

(2010) Lars-Anders Carlson et al.   PLoS Pathogens

Role of Abl Kinase and the Wave2 Signaling Complex in HIV-1 Entry at a Post-Hemifusion Step

(2010) Brooke Harmon et al.   PLoS Pathogens

Formins and microtubules

(2009) F. Bartolini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Retroviral Assembly and Budding Occur through an Actin-Driven Mechanism

(2009) Micha Gladnikoff et al.   BIOPHYSICAL JOURNAL

HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1

(2009) A. R. Anand et al.   BLOOD

HIV-1 Nef Interferes with Host Cell Motility by Deregulation of Cofilin

(2009) Bettina Stolp et al.   Cell Host & Microbe

Actin nucleation and elongation factors: mechanisms and interplay

(2009) Melissa A Chesarone et al.   CURRENT OPINION IN CELL BIOLOGY

A Genome-wide Short Hairpin RNA Screening of Jurkat T-cells for Human Proteins Contributing to Productive HIV-1 Replication

(2009) Man Lung Yeung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intact Lipid Rafts Regulate HIV-1 Tat Protein-Induced Activation of the Rho Signaling and Upregulation of P-Glycoprotein in Brain Endothelial Cells

(2009) Yu Zhong et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HIV-1 Nef-mediated inhibition of T cell migration and its molecular determinants

(2009) In-Woo Park et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Simultaneous Cell-to-Cell Transmission of Human Immunodeficiency Virus to Multiple Targets through Polysynapses

(2009) D. Rudnicka et al.   JOURNAL OF VIROLOGY

Inhibition of T-Cell Receptor-Induced Actin Remodeling and Relocalization of Lck Are Evolutionarily Conserved Activities of Lentiviral Nef Proteins

(2009) J. M. Rudolph et al.   JOURNAL OF VIROLOGY

HIV-1 Nef Inhibits Ruffles, Induces Filopodia, and Modulates Migration of Infected Lymphocytes

(2009) C. Nobile et al.   JOURNAL OF VIROLOGY

Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses

(2009) W. Hubner et al.   SCIENCE

HIV Infection of T Cells: Actin-in and Actin-out

(2009) Y. Liu et al.   Science Signaling

HIV-1 at the immunological and T-lymphocytic virological synapse

(2008) Claudia Haller et al.   BIOLOGICAL CHEMISTRY

Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses

(2008) F. Groot et al.   BLOOD

HIV Envelope-CXCR4 Signaling Activates Cofilin to Overcome Cortical Actin Restriction in Resting CD4 T Cells

(2008) Alyson Yoder et al.   CELL

Hematopoietic cell kinase (Hck) isoforms and phagocyte duties – From signaling and actin reorganization to migration and phagocytosis

(2008) R GUIET et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

HIV-1 Nef Disrupts the Podocyte Actin Cytoskeleton by Interacting with Diaphanous Interacting Protein

(2008) Ting-chi Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes

(2008) M. Barrero-Villar et al.   JOURNAL OF CELL SCIENCE

Induction of the G q Signaling Cascade by the Human Immunodeficiency Virus Envelope Is Required for Virus Entry

(2008) B. Harmon et al.   JOURNAL OF VIROLOGY

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

(2008) James Arthos et al.   NATURE IMMUNOLOGY

Avoiding the void: cell-to-cell spread of human viruses

(2008) Quentin Sattentau   NATURE REVIEWS MICROBIOLOGY

Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study

(2008) Yuntao Wu et al.   Retrovirology

Cellular proteins detected in HIV-1

(2008) David E. Ott   REVIEWS IN MEDICAL VIROLOGY