DNA Tumor Virus Regulation of Host DNA Methylation and Its Implications for Immune Evasion and Oncogenesis

Mechanistic insight into contextual TGF-β signaling

(2018) Ying E Zhang   CURRENT OPINION IN CELL BIOLOGY

DNA methylation aberrancies as a guide for surveillance and treatment of human cancers

(2017) Gangning Liang et al.   Epigenetics

Virus-host interplay in hepatitis B virus infection and epigenetic treatment strategies

(2017) Kai O. Hensel et al.   FEBS Journal

Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B

(2017) Xupeng Hong et al.   HEPATOLOGY

Tumor Suppressor p53 Stimulates the Expression of Epstein-Barr Virus Latent Membrane Protein 1

(2017) Qianli Wang et al.   JOURNAL OF VIROLOGY

HBx represses RIZ1 expression by DNA methyltransferase 1 involvement in decreased miR-152 in hepatocellular carcinoma

(2017) Zhujiang Zhao et al.   ONCOLOGY REPORTS

Evasion of host immune defenses by human papillomavirus

(2017) Joseph A. Westrich et al.   VIRUS RESEARCH

High-Risk Human Papillomavirus E7 Alters Host DNA Methylome and Represses HLA-E Expression in Human Keratinocytes

(2017) Louis Cicchini et al.   Scientific Reports

Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines

(2017) Hector Hernandez-Vargas et al.   Scientific Reports

Epigenetic Pathways of Oncogenic Viruses: Therapeutic Promises

(2016) Amr M. El-Araby et al.   ARCHIV DER PHARMAZIE

TGF-β Tumor Suppression through a Lethal EMT

(2016) Charles J. David et al.   CELL

Epigenetics and Genetics of Viral Latency

(2016) Paul M. Lieberman   Cell Host & Microbe

Interleukin-4 receptor signaling and its binding mechanism: A therapeutic insight from inhibitors tool box

(2016) Zaheer Ul-Haq et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals

(2016) Xinyu Zhang et al.   Epigenetics

Correlation between Methylation of Human Papillomavirus-16 L1 Gene and Cervical Carcinoma in Uyghur Women

(2016) Mayineur Niyazi et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis

(2016) Hongde Li et al.   International Journal of Biological Sciences

CXCL14 as an emerging immune and inflammatory modulator

(2016) Jing Lu et al.   Journal of Inflammation-London

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity

(2016) Joan Barau et al.   SCIENCE

KSHV-Mediated Angiogenesis in Tumor Progression

(2016) Pravinkumar Purushothaman et al.   Viruses-Basel

Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14

(2016) Louis Cicchini et al.   mBio

Microarray analysis on the lncRNA expression profile in male hepatocelluar carcinoma patients with chronic hepatitis B virus infection

(2016) Jianjun Niu et al.   Oncotarget

Epigenetic impact of infection on carcinogenesis: mechanisms and applications

(2016) Naoko Hattori et al.   Genome Medicine

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells

(2016) Zachary B. Davis et al.   PLoS Pathogens

Cell Cycle Regulatory Functions of the KSHV Oncoprotein LANA

(2016) Fang Wei et al.   Frontiers in Microbiology

Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

(2016) Simone A. Joosten et al.   Journal of Immunology Research

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Aberrant DNA methylation ofDLX4andSIM1is a predictive marker for disease progression of uterine cervical low-grade squamous intraepithelial lesion

(2015) Junichi Sakane et al.   DIAGNOSTIC CYTOPATHOLOGY

Longitudinal assessment of DNA methylation changes during HPVE6E7-induced immortalization of primary keratinocytes

(2015) Denise M Schütze et al.   Epigenetics

Oncovirus Kaposi Sarcoma Herpesvirus (KSHV) Represses Tumor Suppressor PDLIM2 to Persistently Activate Nuclear Factor κB (NF-κB) and STAT3 Transcription Factors for Tumorigenesis and Tumor Maintenance

(2015) Fan Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypermethylation of the interferon regulatory factor 5 promoter in Epstein-Barr virus-associated gastric carcinoma

(2015) Seung Myung Dong et al.   JOURNAL OF MICROBIOLOGY

Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins

(2015) Christina Habiger et al.   JOURNAL OF VIROLOGY

Hepatitis B virus X protein upregulates DNA methyltransferase 3A/3B and enhances SOCS-1CpG island methylation

(2015) XIAOYU FU et al.   Molecular Medicine Reports

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2

(2015) H Fan et al.   ONCOGENE

Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling

(2015) Johan A. den Boon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice

(2015) Ryu-Ichiro Hata et al.   Scientific Reports

Laser capture microdissection as a tool to evaluate human papillomavirus genotyping and methylation as biomarkers of persistence and progression of anal lesions

(2015) Alyssa M Cornall et al.   BMJ Open

Oncogenic potential of hepatitis B virus encoded proteins

(2015) Marc Ringelhan et al.   Current Opinion in Virology

Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Induces the Oncogenic miR-17-92 Cluster and Down-Regulates TGF-β Signaling

(2015) Hong Seok Choi et al.   PLoS Pathogens

Depletion of CpG Dinucleotides in Papillomaviruses and Polyomaviruses: A Role for Divergent Evolutionary Pressures

(2015) Mohita Upadhyay et al.   PLoS One

Pathogens Hijack the Epigenome

(2014) Natalie C. Silmon de Monerri et al.   AMERICAN JOURNAL OF PATHOLOGY

Evolving insights on how cytosine methylation affects protein-DNA binding

(2014) A. C. Dantas Machado et al.   Briefings in Functional Genomics

The Future of Cancer Therapy: Selecting Patients Likely to Respond to PD1/L1 Blockade

(2014) A. Ribas et al.   CLINICAL CANCER RESEARCH

Epigenetic Repression of Interleukin 2 Expression in Senescent CD4+T Cells During Chronic HIV Type 1 Infection

(2014) Kaori Nakayama-Hosoya et al.   JOURNAL OF INFECTIOUS DISEASES

Kaposi's Sarcoma-Associated Herpesvirus Downregulates Transforming Growth Factor  2 To Promote Enhanced Stability of Capillary-Like Tube Formation

(2014) T. A. DiMaio et al.   JOURNAL OF VIROLOGY

Alpha-Defensin HD5 Inhibits Furin Cleavage of Human Papillomavirus 16 L2 To Block Infection

(2014) Mayim E. Wiens et al.   JOURNAL OF VIROLOGY

miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis

(2014) Chartia Ching-Mei Cheung et al.   Molecular Cancer

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

(2014) Thomas Powles et al.   NATURE

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Kaposi's Sarcoma-Associated Herpesvirus (KSHV) vIL-6 Promotes Cell Proliferation and Migration by Upregulating DNMT1 via STAT3 Activation

(2014) Jing Wu et al.   PLoS One

Transcription of Hepatitis B Virus Covalently Closed Circular DNA Is Regulated by CpG Methylation during Chronic Infection

(2014) Yongmei Zhang et al.   PLoS One

HBx induces hypomethylation of distal intragenic CpG islands required for active expression of developmental regulators

(2014) Sun-Min Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of hepatitis B virus-induced hepatocarcinogenesis

(2014) Mirko Tarocchi   WORLD JOURNAL OF GASTROENTEROLOGY

Antitumor efficacy of C-X-C motif chemokine ligand 14 in hepatocellular carcinomain vitroandin vivo

(2013) Weilin Wang et al.   CANCER SCIENCE

Dnmt3L Antagonizes DNA Methylation at Bivalent Promoters and Favors DNA Methylation at Gene Bodies in ESCs

(2013) Francesco Neri et al.   CELL

Epigenetic silencing ofSFRP1andSFRP5by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway

(2013) Qing Xie et al.   INTERNATIONAL JOURNAL OF CANCER

Quantitative measurement of Human Papillomavirus type 16 L1/L2 DNA methylation correlates with cervical disease grade

(2013) Dean Bryant et al.   JOURNAL OF CLINICAL VIROLOGY

CpG Dinucleotide Frequencies Reveal the Role of Host Methylation Capabilities in Parvovirus Evolution

(2013) M. Upadhyay et al.   JOURNAL OF VIROLOGY

Hepatitis B Virus X Protein-Induced Aberrant Epigenetic Modifications Contributing to Human Hepatocellular Carcinoma Pathogenesis

(2013) Y. Tian et al.   MOLECULAR AND CELLULAR BIOLOGY

Promising systemic immunotherapies in head and neck squamous cell carcinoma

(2013) Neil Gildener-Leapman et al.   ORAL ONCOLOGY

Concordant Promoter Methylation of Transforming Growth Factor-Beta Receptor Types I and II Occurs Early in Esophageal Squamous Cell Carcinoma

(2012) Zhiming Dong et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Impact of Methylation on the Physical Properties of DNA

(2012) Alberto Pérez et al.   BIOPHYSICAL JOURNAL

Cervical Cancers Require the Continuous Expression of the Human Papillomavirus Type 16 E7 Oncoprotein Even in the Presence of the Viral E6 Oncoprotein

(2012) Sean F. Jabbar et al.   CANCER RESEARCH

miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A

(2012) Xufu Wei et al.   CELLULAR SIGNALLING

Epithelial Cell Responses to Infection with Human Papillomavirus

(2012) M. A. Stanley   CLINICAL MICROBIOLOGY REVIEWS

A Kaposi's Sarcoma-Associated Herpesvirus MicroRNA and Its Variants Target the Transforming Growth Factor   Pathway To Promote Cell Survival

(2012) X. Lei et al.   JOURNAL OF VIROLOGY

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Global Burden of Human Papillomavirus and Related Diseases

(2012) David Forman et al.   VACCINE

The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation

(2012) Valerie A. Morris et al.   VIROLOGY

Novel mechanisms of EBV-induced oncogenesis

(2012) Nancy Raab-Traub   Current Opinion in Virology

Early Natural History of Incident, Type-Specific Human Papillomavirus Infections in Newly Sexually Active Young Women

(2011) R. L. Winer et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Proteomic analysis of the interleukin-4 (IL-4) response in hepatitis B virus-positive human hepatocelluar carcinoma cell line HepG2.2.15

(2011) Yuqin Yao et al.   ELECTROPHORESIS

Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis

(2011) Maureen A. Sartor et al.   Epigenetics

Interferon Regulatory Factor 4 (IRF-4) Targets IRF-5 to Regulate Epstein-Barr Virus Transformation

(2011) Dongsheng Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatitis B virus X protein overcomes all-trans retinoic acid-induced cellular senescence by downregulating levels of p16 and p21 via DNA methylation

(2011) S.-H. Park et al.   JOURNAL OF GENERAL VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus-Encoded MicroRNA miR-K12-11 Attenuates Transforming Growth Factor Beta Signaling through Suppression of SMAD5

(2011) Y. Liu et al.   JOURNAL OF VIROLOGY

Epigenetic and Transcriptional Changes Which Follow Epstein-Barr Virus Infection of Germinal Center B Cells and Their Relevance to the Pathogenesis of Hodgkin's Lymphoma

(2011) S. Leonard et al.   JOURNAL OF VIROLOGY

High-Risk Human Papillomaviruses Repress Constitutive Kappa Interferon Transcription via E6 To Prevent Pathogen Recognition Receptor and Antiviral-Gene Expression

(2011) J. Reiser et al.   JOURNAL OF VIROLOGY

Cytosine methylation alters DNA mechanical properties

(2011) Philip M. D. Severin et al.   NUCLEIC ACIDS RESEARCH

Differential Methylation of the HPV 16 Upstream Regulatory Region during Epithelial Differentiation and Neoplastic Transformation

(2011) Svetlana Vinokurova et al.   PLoS One

Induction of Cyclooxygenase-2 Expression by Hepatitis B Virus Depends on Demethylation-associated Recruitment of Transcription Factors to the Promoter

(2011) Xin Yue et al.   Virology Journal

Expression of a chemokine BRAK/CXCL14 in oral floor carcinoma cells reduces the settlement rate of the cells and suppresses their proliferation in vivo

(2010) Shin Ito et al.   BIOMEDICAL RESEARCH-TOKYO

Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma

(2010) R. Liu et al.   BLOOD

hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis

(2010) Jillian de Wilde et al.   BMC CANCER

DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae

(2010) Masaki Yamashita et al.   CANCER SCIENCE

Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer

(2010) N. Matsumura et al.   GENOME RESEARCH

Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1

(2010) Jinfeng Huang et al.   HEPATOLOGY

Epigenetic modulation of host: new insights into immune evasion by viruses

(2010) Dwaipayan Adhya et al.   JOURNAL OF BIOSCIENCES

Hepatitis B Virus Replication Induces Methylation of both Host and Viral DNA

(2010) P. Vivekanandan et al.   JOURNAL OF VIROLOGY

The presence of JC virus in gastric carcinomas correlates with patient's age, intestinal histological type and aberrant methylation of tumor suppressor genes

(2010) Feryel Ksiaa et al.   MODERN PATHOLOGY

Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis

(2010) M Tessema et al.   ONCOGENE

Epigenetic reprogramming of host genes in viral and microbial pathogenesis

(2010) Konstantinos Paschos et al.   TRENDS IN MICROBIOLOGY

Kaposi sarcoma-associated herpesvirus (KSHV): Molecular biology and oncogenesis

(2009) Kwun Wah Wen et al.   CANCER LETTERS

Persistence of High-Grade Cervical Dysplasia and Cervical Cancer Requires the Continuous Expression of the Human Papillomavirus Type 16 E7 Oncogene

(2009) S. F. Jabbar et al.   CANCER RESEARCH

Epigenetic Silencing of Interferon-  in Human Papillomavirus Type 16-Positive Cells

(2009) B. Rincon-Orozco et al.   CANCER RESEARCH

Activation of DNA Methyltransferase 1 by EBV Latent Membrane Protein 2A Leads to Promoter Hypermethylation of PTEN Gene in Gastric Carcinoma

(2009) R. Hino et al.   CANCER RESEARCH

Frequent hypermethylation of RASSF1A tumour suppressor gene promoter and presence of Merkel cell polyomavirus in small cell lung cancer

(2009) Peter Helmbold et al.   EUROPEAN JOURNAL OF CANCER

Methylation of the long control region of HPV16 is related to the severity of cervical neoplasia

(2009) Dah-Ching Ding et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

CpG islands - ‘A rough guide’

(2009) Robert S. Illingworth et al.   FEBS LETTERS

TGFβR2aberrant methylation is a potential prognostic marker and therapeutic target in multiple myeloma

(2009) Fabrício de Carvalho et al.   INTERNATIONAL JOURNAL OF CANCER

Hepatitis B virus X protein overcomes the growth-inhibitory potential of retinoic acid by downregulating retinoic acid receptor- 2 expression via DNA methylation

(2009) J. K. Jung et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis B virus X protein induces hypermethylation of p16INK4Apromoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis

(2009) Y.-Z. Zhu et al.   JOURNAL OF VIRAL HEPATITIS

Frequent occurrence ofRASSF1Apromoter hypermethylation and merkel cell polyomavirus in merkel cell carcinoma

(2009) Peter Helmbold et al.   MOLECULAR CARCINOGENESIS

KSHV LANA inhibits TGF-  signaling through epigenetic silencing of the TGF-  type II receptor

(2008) D. L. Di Bartolo et al.   BLOOD

Epstein–Barr virus latent membrane protein 1 suppresses the growth-inhibitory effect of retinoic acid by inhibiting retinoic acid receptor-β2 expression via DNA methylation

(2008) So Young Seo et al.   CANCER LETTERS

Methylation Silencing of Transforming Growth Factor-  Receptor Type II in Rat Prostate Cancers

(2008) S. Yamashita et al.   CANCER RESEARCH

Critical role for constitutive type I interferon signaling in the prevention of cellular transformation

(2008) Hui-min Chen et al.   CANCER SCIENCE

IRF-5 Is a Mediator of the Death Receptor-induced Apoptotic Signaling Pathway

(2008) Guodong Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A

(2008) Da-Li Zheng et al.   JOURNAL OF HEPATOLOGY

Presence and role of cytosine methylation in DNA viruses of animals

(2008) K. Hoelzer et al.   NUCLEIC ACIDS RESEARCH