Multiomics biomarkers for the prediction of nonalcoholic fatty liver disease severity

Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis

(2018) Buket Yiğit et al.   GUT

The nonalcoholic steatohepatitis metabotype: Imbalance of circulating amino acids and transamination reactions reflect impaired mitochondrial function

(2018) Silvia Sookoian et al.   HEPATOLOGY

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

(2017) Cristina Alonso et al.   GASTROENTEROLOGY

Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance

(2017) Melania Gaggini et al.   HEPATOLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

A simple scoring system using type IV collagen 7S and aspartate aminotransferase for diagnosing nonalcoholic steatohepatitis and related fibrosis

(2017) Takeshi Okanoue et al.   JOURNAL OF GASTROENTEROLOGY

Metabox: A Toolbox for Metabolomic Data Analysis, Interpretation and Integrative Exploration

(2017) Kwanjeera Wanichthanarak et al.   PLoS One

A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease

(2017) Martina Goffredo et al.   Nutrients

Cell-free DNA methylation as liquid biopsy for the assessment of fibrosis in patients with nonalcoholic steatohepatitis: a gap between innovation and implementation

(2017) Silvia Sookoian et al.   HEPATOBILIARY SURGERY AND NUTRITION

Nasal DNA methylation differentiates corticosteroid treatment response in pediatric asthma: A pilot study

(2017) Xue Zhang et al.   PLoS One

A multi-component classifier for nonalcoholic fatty liver disease (NAFLD) based on genomic, proteomic and phenomic data domains

(2017) G. Craig Wood et al.   Scientific Reports

Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level1,2

(2016) Silvia Sookoian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites

(2016) You Zhou et al.   Clinical Gastroenterology and Hepatology

Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease

(2016) Timothy Hardy et al.   GUT

Nonalcoholic fatty liver disease and metabolic syndrome: Shared genetic basis of pathogenesis

(2016) Silvia Sookoian et al.   HEPATOLOGY

Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood

(2016) Martin L. Decaris et al.   HEPATOLOGY

Metabolite Signatures of Metabolic Risk Factors and their Longitudinal Changes

(2016) Xiaoyan Yin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial genome architecture in non-alcoholic fatty liver disease

(2016) Silvia Sookoian et al.   JOURNAL OF PATHOLOGY

Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency

(2016) Silvia Sookoian et al.   LIVER INTERNATIONAL

PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery

(2016) Marcin Krawczyk et al.   Surgery for Obesity and Related Diseases

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis

(2016) Darren Plant et al.   Arthritis & Rheumatology

The dual and opposite role of theTM6SF2-rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta-analysis

(2015) Carlos J. Pirola et al.   HEPATOLOGY

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity

(2015) Silvia Sookoian et al.   HEPATOLOGY

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

Performance of Serum microRNAs -122, -192 and -21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis

(2015) Philip P. Becker et al.   PLoS One

Liver enzymes, metabolomics and genome-wide association studies: From systems biology to the personalized medicine

(2015) Silvia Sookoian et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Nonalcoholic fatty liver disease

(2015) Elizabeth M. Brunt et al.   Nature Reviews Disease Primers

Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells

(2014) Hae-Ki Min et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis

(2014) Carlos J Pirola et al.   GUT

PNPLA3gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease

(2014) Jiayun Shen et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

Metabolic make-up of NASH: from fat and sugar to amino acids

(2014) Silvia Sookoian et al.   Nature Reviews Gastroenterology & Hepatology

A Pilot Study of Serum MicroRNAs Panel as Potential Biomarkers for Diagnosis of Nonalcoholic Fatty Liver Disease

(2014) Youwen Tan et al.   PLoS One

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

(2014) Yang-Lin Liu et al.   Nature Communications

Erratum: Serotonin tranporter methylation and response to cognitive behaviour therapy in children with anxiety disorders

(2014) S Roberts et al.   Translational Psychiatry

DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery

(2013) Markus Ahrens et al.   Cell Metabolism

Metabolic Phenotyping and Systems Biology Approaches to Understanding Metabolic Syndrome and Fatty Liver Disease

(2013) Marc–Emmanuel Dumas et al.   GASTROENTEROLOGY

Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease

(2013) Kenneth Cusi et al.   JOURNAL OF HEPATOLOGY

A 4-Polymorphism Risk Score Predicts Steatohepatitis in Children With Nonalcoholic Fatty Liver Disease

(2013) Valerio Nobili et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Systems Biology Elucidates Common Pathogenic Mechanisms between Nonalcoholic and Alcoholic-Fatty Liver Disease

(2013) Silvia Sookoian et al.   PLoS One

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis

(2012) Naoki Tanaka et al.   HEPATOLOGY

Validation of terminal peptide of procollagen III for the detection and assessment of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease

(2012) Sudeep Tanwar et al.   HEPATOLOGY

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans

(2011) K. Sevastianova et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA

(2011) Atanas Kamburov et al.   BIOINFORMATICS

Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data

(2011) Alla Karnovsky et al.   BIOINFORMATICS

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   HEPATOLOGY

Circulating MicroRNAs in Patients with Chronic Hepatitis C and Non-Alcoholic Fatty Liver Disease

(2011) Silvia Cermelli et al.   PLoS One

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

(2011) Lisa S. Shock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter

(2010) Silvia Sookoian et al.   HEPATOLOGY

Plasma metabolomic profile in nonalcoholic fatty liver disease

(2010) Satish C. Kalhan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pathology of nonalcoholic fatty liver disease

(2010) Elizabeth M. Brunt   Nature Reviews Gastroenterology & Hepatology

Histopathology of Non-Alcoholic Fatty Liver Disease

(2009) Elizabeth M. Brunt   Clinics in Liver Disease

Prediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using Metabolic and Genetic Factors

(2009) Anna Kotronen et al.   GASTROENTEROLOGY

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

Proteomic analysis of serum in patients with non-alcoholic steatohepatitis using matrix-assisted laser desorption ionization time-of-flight mass spectrometry

(2009) Engin Ulukaya et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

A diagnostic model to differentiate simple steatosis from nonalcoholic steatohepatitis based on the likelihood ratio form of Bayes theorem

(2008) Silvia Sookoian et al.   CLINICAL BIOCHEMISTRY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS