Liver enzymes, metabolomics and genome-wide association studies: From systems biology to the personalized medicine

Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity

(2015) Silvia Sookoian et al.   HEPATOLOGY

Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis

(2014) A.-J. Chamorro et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells

(2014) Hae-Ki Min et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress

(2014) María C. Salgado et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis

(2014) Carlos J Pirola et al.   GUT

Pnpla3I148Mknockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

(2014) Eriks Smagris et al.   HEPATOLOGY

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

(2014) Oddgeir L Holmen et al.   NATURE GENETICS

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

Metabolic make-up of NASH: from fat and sugar to amino acids

(2014) Silvia Sookoian et al.   Nature Reviews Gastroenterology & Hepatology

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

(2014) Adil Mardinoglu et al.   Nature Communications

Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B

(2013) Mauro Viganò et al.   HEPATOLOGY

PNPLA3, the history of an orphan gene of the potato tuber protein family that found an organ: The liver

(2013) Silvia Sookoian et al.   HEPATOLOGY

Association between thePNPLA3(rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data

(2013) Eric Trépo et al.   HEPATOLOGY

Microsomal Triglyceride Transfer Protein Inhibition Induces Endoplasmic Reticulum Stress and Increases Gene Transcription via Ire1α/cJun to Enhance Plasma ALT/AST

(2013) Joby Josekutty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Liver Is Associated with Transcriptional Downregulation of Stearoyl-CoA Desaturase and Impaired Protein Dimerization

(2013) Tomas Fernández Gianotti et al.   PLoS One

The Genetic Epidemiology of Nonalcoholic Fatty Liver Disease

(2012) Silvia Sookoian et al.   Clinics in Liver Disease

Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans

(2012) INGALILL RAFTER et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet

(2012) Günther Silbernagel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

(2012) Johannes Kettunen et al.   NATURE GENETICS

Metabolic Adaptive ALT Isoenzyme Response in Livers of C57/BL6 Mice Treated with Dexamethasone

(2012) William J. Reagan et al.   TOXICOLOGIC PATHOLOGY

PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease

(2012) Silvia Sookoian   WORLD JOURNAL OF GASTROENTEROLOGY

Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome

(2012) Silvia Sookoian   WORLD JOURNAL OF GASTROENTEROLOGY

Managing biological complexity across orthologs with a visual knowledgebase of documented biomolecular interactions

(2012) Vincent VanBuren et al.   Scientific Reports

Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   ATHEROSCLEROSIS

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   HEPATOLOGY

Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease

(2011) Yongcheng Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels

(2011) Haiqing Shen et al.   JOURNAL OF HUMAN GENETICS

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

(2011) John C Chambers et al.   NATURE GENETICS

Alanine Aminotransferase Regulation by Androgens in Non-hepatic Tissues

(2011) Christopher C. Coss et al.   PHARMACEUTICAL RESEARCH

Patatin-Like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C

(2010) Luca Valenti et al.   HEPATOLOGY

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Iron stores, liver transaminase levels and metabolic risk in healthy teenagers

(2009) E. Aigner et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

(2009) Silvia Sookoian et al.   JOURNAL OF LIPID RESEARCH

Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis

(2009) Rui Liu et al.   LIVER INTERNATIONAL

Epidemiology and Genetic Epidemiology of the Liver Function Test Proteins

(2009) Nilufer Rahmioglu et al.   PLoS One

Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

(2008) Xin Yuan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Aminotransferase Levels and 20-Year Risk of Metabolic Syndrome, Diabetes, and Cardiovascular Disease

(2008) Wolfram Goessling et al.   GASTROENTEROLOGY

Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects

(2008) S. Kechagias et al.   GUT

Alanine aminotransferase is associated with atherothrombotic risk factors in a British South Asian population

(2008) K. KAIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes

(2008) Petra Thulin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

(2008) Christian Gieger et al.   PLoS Genetics