Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy

Quantification of mitochondrial morphology in neurites of dopaminergic neurons using multiple parameters

(2016) Lyle Wiemerslage et al.   JOURNAL OF NEUROSCIENCE METHODS

A validated active contour method driven by parabolic arc model for detection and segmentation of mitochondria

(2016) Serdar F. Tasel et al.   JOURNAL OF STRUCTURAL BIOLOGY

Fully automated software for quantitative measurements of mitochondrial morphology

(2016) P. Mason McClatchey et al.   MITOCHONDRION

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sparse deconvolution of high-density super-resolution images

(2016) Siewert Hugelier et al.   Scientific Reports

Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning

(2015) Anthony P. Leonard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Automated detection of whole-cell mitochondrial motility and its dependence on cytoarchitectural integrity

(2015) Judith Kandel et al.   BIOTECHNOLOGY AND BIOENGINEERING

Redox Homeostasis and Mitochondrial Dynamics

(2015) Peter H.G.M. Willems et al.   Cell Metabolism

Toward high-content screening of mitochondrial morphology and membrane potential in living cells

(2015) Eligio F. Iannetti et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Automatic quantification of mitochondrial fragmentation from two-photon microscope images of mouse brain tissue

(2015) E. LIHAVAINEN et al.   JOURNAL OF MICROSCOPY

Novel computer vision algorithm for the reliable analysis of organelle morphology in whole cell 3D images — A pilot study for the quantitative evaluation of mitochondrial fragmentation in amyotrophic lateral sclerosis

(2015) Janin Lautenschläger et al.   MITOCHONDRION

Assessing Mitochondrial Movement Within Neurons: Manual Versus Automated Tracking Methods

(2015) Helena Bros et al.   TRAFFIC

Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning

(2015) Lionel Blanchet et al.   Scientific Reports

Principal component analysis

(2014) Rasmus Bro et al.   Analytical Methods

Mitochondrial hyperpolarization during chronic complex I inhibition is sustained by low activity of complex II, III, IV and V

(2014) Marleen Forkink et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria as signaling organelles

(2014) Navdeep S Chandel   BMC BIOLOGY

Regulation and Quantification of Cellular Mitochondrial Morphology and Content

(2014) Karl Tronstad et al.   CURRENT PHARMACEUTICAL DESIGN

The hallmarks of fibroblast ageing

(2014) Julia Tigges et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Segmentation and quantification of subcellular structures in fluorescence microscopy images using Squassh

(2014) Aurélien Rizk et al.   Nature Protocols

Automated Quantification and Integrative Analysis of 2D and 3D Mitochondrial Shape and Network Properties

(2014) Julie Nikolaisen et al.   PLoS One

Photo-Induction and Automated Quantification of Reversible Mitochondrial Permeability Transition Pore Opening in Primary Mouse Myotubes

(2014) Lionel Blanchet et al.   PLoS One

Mitochondrial morphology transitions and functions: implications for retrograde signaling?

(2013) Martin Picard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Machine learning in cell biology – teaching computers to recognize phenotypes

(2013) Christoph Sommer et al.   JOURNAL OF CELL SCIENCE

Unsupervised mitochondria segmentation using recursive spectral clustering and adaptive similarity models

(2013) Julia Dietlmeier et al.   JOURNAL OF STRUCTURAL BIOLOGY

An Improved Quantitative Approach for the Assessment of Mitochondrial Fragmentation in Chemoresistant Ovarian Cancer Cells

(2013) Lee Farrand et al.   PLoS One

Ten misconceptions about antioxidants

(2013) Aalt Bast et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Computational classification of mitochondrial shapes reflects stress and redox state

(2013) T Ahmad et al.   Cell Death & Disease

Mytoe: automatic analysis of mitochondrial dynamics

(2012) Eero Lihavainen et al.   BIOINFORMATICS

Method: automatic segmentation of mitochondria utilizing patch classification, contour pair classification, and automatically seeded level sets

(2012) Richard J Giuly et al.   BMC BIOINFORMATICS

Isolated Mitochondrial Complex I Deficiency: Explorative Data Analysis of Patient Cell Parameters

(2012) Lionel Blanchet et al.   CURRENT PHARMACEUTICAL DESIGN

OXPHOS mutations and neurodegeneration

(2012) Werner J H Koopman et al.   EMBO JOURNAL

Computerized detection and segmentation of mitochondria on electron microscope images

(2012) E.U. MUMCUOGLU et al.   JOURNAL OF MICROSCOPY

Biological imaging software tools

(2012) Kevin W Eliceiri et al.   NATURE METHODS

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multi-Parametric Analysis and Modeling of Relationships between Mitochondrial Morphology and Apoptosis

(2012) Yara Reis et al.   PLoS One

A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size

(2012) Toshimori Kitami et al.   PLoS One

Automatic Morphological Subtyping Reveals New Roles of Caspases in Mitochondrial Dynamics

(2011) Jyh-Ying Peng et al.   PLoS Computational Biology

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High content screening: seeing is believing

(2010) Fabian Zanella et al.   TRENDS IN BIOTECHNOLOGY

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

(2009) Werner J.H. Koopman et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dynamics in human NADH:ubiquinone oxidoreductase deficiency

(2009) Peter H.G.M. Willems et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

(2009) Yan Feng et al.   NATURE REVIEWS DRUG DISCOVERY

Inherited complex I deficiency is associated with faster protein diffusion in the matrix of moving mitochondria

(2008) Werner J. H. Koopman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Computer-assisted live cell analysis of mitochondrial membrane potential, morphology and calcium handling

(2008) Werner J.H. Koopman et al.   METHODS

What is principal component analysis?

(2008) Markus Ringnér   NATURE BIOTECHNOLOGY

Life cell quantification of mitochondrial membrane potential at the single organelle level

(2007) Felix Distelmaier et al.   CYTOMETRY PART A