Article
Developmental Biology
Donn A. Van Deren, Shrutokirti De, Ben Xu, Kayla M. Eschenbacher, Shuhua Zhang, Mario R. Capecchi
Summary: This study demonstrates that Hoxb8 microglia are derived from the Hoxb8 lineage and have a distinct ontogeny. Dysfunctional Hoxb8 microglia can contribute to anxiety and obsessive-compulsive behaviors. Additionally, Hoxb8 progenitors can mark erythromyeloid progenitors, hematopoietic stem cells, and their progeny, particularly monocytes. In adulthood, all immune lineages and resident macrophages in hematopoietic-lymphoid tissues are derived from Hoxb8 precursors.
Article
Cell & Tissue Engineering
Laleh Haghverdi, Leif S. Ludwig
Summary: The concept of cell fate is about the future identity of a cell and its daughters through cell differentiation and division. Understanding and manipulating cell fate has been a long-standing goal in developmental and regenerative biology. Recent advancements in single-cell genomics and integrative lineage-tracing approaches have provided insights into the molecular features that can predict cell fate.
Article
Cell & Tissue Engineering
Keegan L. Vaughan, Anthony M. Franchini, Harrison G. Kern, B. Paige Lawrence
Summary: The aryl hydrocarbon receptor (AHR) plays a crucial role in regulating steady-state hematopoiesis, influencing HSPC homeostasis and lineage potential. The data presented in the study offer potential insights into how deliberate modulation of AHR signaling could aid in treating a broad range of diseases that require the hematopoietic compartment.
STEM CELLS AND DEVELOPMENT
(2021)
Review
Biology
Wade W. Sugden, Trista E. North
Summary: Specialized subsets of endothelial cells in different organs and regions of the vascular tree carry out unique functions, with a population of hemogenic endothelial cells transforming into hematopoietic stem cells in embryos. Recent advances in the zebrafish model have uncovered factors facilitating hemogenic commitment and the transition to blood stem cells, such as biomechanical influences and metabolic cues. Transcriptomic-based approaches have revealed key signals in the embryonic niche that regulate hematopoiesis.
Review
Pharmacology & Pharmacy
Li Chen, Desong Kong, Siwei Xia, Feixia Wang, Zhanghao Li, Feng Zhang, Shizhong Zheng
Summary: Liver fibrosis is a repair process of chronic liver injuries, and its progression relies on the activation of hepatic stellate cells and remodeling of the extracellular matrix. Liver fibrosis can lead to liver dysfunction and hepatocellular carcinoma. Innate immune cells and autophagy play complex roles in liver fibrosis. Further research on these roles is crucial for the prevention and treatment of liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Bo Yu, Bingyan Wu, Pingshan Hong, Huan Peng, Mengyun Zhang, Qi Zhang, Lijuan Liu, Xiaofei Liu, Yang Geng, Jinyong Wang, Yu Lan
Summary: This study reveals that the coordinated action of Runx1, Hoxa9, Hlf, and Hoxa7 leads to the generation of hematopoietic progenitor cells with the capacity for multilineage hematopoietic reconstitution.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Dongchan Kim, Dong-Yeop Shin, Jun Liu, Na-rae Jeong, Youngil Koh, Junshik Hong, Xinxin Huang, Hal E. Broxmeyer, Sung-Soo Yoon
Summary: AhR antagonist CH223191 expands HSCs and MK-lineage cells, and has potential as an auxiliary treatment for patients with abnormal thrombopoiesis.
STEM CELL REVIEWS AND REPORTS
(2022)
Review
Biology
Dan Hultmark, Istvan Ando
Summary: Hemocytes, similar to vertebrate blood cells, play important roles in insect development and immunity. New technology, such as single-cell transcriptomic analysis in combination with Drosophila genetics, allows for a better understanding of their functions. This review compares data from different insects and identifies major classes of hemocytes with distinct morphology and functions.
Review
Hematology
Robin P. Choudhury, Laurienne Edgar, Mikael Ryden, Edward A. Fisher
Summary: Physiological functions are intricately intertwined, with evidence from immunometabolism field showing that cells can be programmed by changes in metabolic environment through epigenetic modifications, causing persistent changes. Understanding these processes can have significant implications for the diagnosis and treatment of diabetes and related metabolic states.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mengmeng Qin, Minghui Li, Ge Song, Canyu Yang, Peiyao Wu, Wenbing Dai, Hua Zhang, Xueqing Wang, Yiguang Wang, Demin Zhou, Bing He, Qiang Zhang
Summary: This study successfully utilized bisphosphonates as innate immune regulators in combination with peptide antigens and a nanocarrier to enhance immune response and achieve a 50% total disappearance of tumor cells. The combination also showed promising results in a prophylactic study with no tumor occurrence in the nanovaccine group during a 110-day study with 3 time tumor challenges.
Article
Multidisciplinary Sciences
Carys A. Croft, Anna Thaller, Solenne Marie, Jean-Marc Doisne, Laura Surace, Rui Yang, Anne Puel, Jacinta Bustamante, Jean-Laurent Casanova, James P. Di Santo
Summary: The Notch signaling pathway plays a crucial role in the development of innate lymphoid cells (ILCs) from human ILC precursors. The study identifies a Notch->RORC->IL-23R pathway that regulates ILC differentiation. These findings may have implications for expanding functional ILC subsets in vitro and developing novel ILC therapies for human diseases.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Carlotta Barahona de Brito, Stefan Klein-Hessling, Edgar Serfling, Amiya Kumar Patra
Summary: NFATc1 plays a critical role in the maintenance and differentiation of HSPCs. Its absence leads to defective HSPC development and impaired differentiation of lymphoid, myeloid, and erythroid lineages.
Review
Cell Biology
Anna Konturek-Ciesla, David Bryder
Summary: Appropriate production of mature blood cells is essential for organismal health. This article describes tools and methods for tracing HSC lineage in mice and integrating them with single-cell molecular analysis. By combining new insights from experiments with past knowledge, we gain a better understanding of HSC-derived hematopoiesis in humans.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Matthew J. Kim, Rodrigo J. Valderrabano, Joy Y. Wu
Summary: This article discusses various populations of osteoblasts at different stages of differentiation and summarizes the role of the osteoblast lineage in supporting hematopoiesis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Wenli Liu, Nataliya Ostberg, Mustafa Yalcinkaya, Huijuan Dou, Kaori Endo-Umeda, Yang Tang, Xintong Hou, Tong Xiao, Trevor P. Fidler, Sandra Abramowicz, Yong-Guang Yang, Oliver Soehnlein, Alan R. Tall, Nan Wang
Summary: Elevated hematocrit is associated with cardiovascular risk, and the JAK2(V617F) mutation increases the risk of atherosclerosis. Research suggests that the impact of red blood cells on cardiovascular risk may be related to ferroptosis induced by erythrophagocytosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biophysics
Ann Dahlberg, Wendy Leisenring, Marie Bleakley, Soheil Meshinchi, K. Scott Baker, Corinne Summers, Brandon Hadland, Colleen Delaney, Kanwaldeep Mallhi, Lauri Burroughs, Paul Carpenter, Ann Woolfrey
BONE MARROW TRANSPLANTATION
(2019)
Article
Cell & Tissue Engineering
Michihiro Kobayashi, Stefan P. Tarnawsky, Haichao Wei, Akansha Mishra, Nathalia Azevedo Portilho, Pamela Wenzel, Brian Davis, Jiaqian Wu, Brandon Hadland, Momoko Yoshimoto
Article
Immunology
Sven D. Sommerfeld, Christopher Cherry, Remi M. Schwab, Liam Chung, David R. Maestas, Philippe Laffont, Julie E. Stein, Ada Tam, Sudipto Ganguly, Franck Housseau, Janis M. Taube, Drew M. Pardoll, Patrick Cahan, Jennifer H. Elisseeff
SCIENCE IMMUNOLOGY
(2019)
Article
Cell & Tissue Engineering
Neha Nagpal, Jianing Wang, Jing Zeng, Emily Lo, Diane H. Moon, Kevin Luk, Roman O. Braun, Lauri M. Burroughs, Sioban B. Keel, Christopher Reilly, R. Coleman Lindsley, Scot A. Wolfe, Albert K. Tai, Patrick Cahan, Daniel E. Bauer, Yick W. Fong, Suneet Agarwal
Article
Cell & Tissue Engineering
Michael J. Chen, Edroaldo Lummertz da Rocha, Patrick Cahan, Caroline Kubaczka, Phoebe Hunter, Patricia Sousa, Nathaniel K. Mullin, Yuko Fujiwara, Minh Nguyen, Yuqi Tan, Yi Zhou, Trista E. North, Leonard Zon, George Q. Daley, Thorsten M. Schlaeger
Article
Developmental Biology
Qin Bian, Yu-Hao Cheng, Jordan P. Wilson, Emily Y. Su, Dong Won Kim, Hong Wang, Sooyeon Yoo, Seth Blackshaw, Patrick Cahan
Letter
Oncology
Quy Le, Brandon Hadland, Soheil Meshinchi, Irwin Bernstein
Editorial Material
Biochemistry & Molecular Biology
Emily K. W. Lo, Emily Y. Su, Patrick Cahan
Article
Multidisciplinary Sciences
Christian Mandrycky, Brandon Hadland, Ying Zheng
Article
Multidisciplinary Sciences
Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M. Heck, Takashi Ishida, Dana L. Jackson, Tomer Itkin, Jason M. Butler, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein
Summary: In this study, the authors used single cell RNA-sequencing to map the signaling interactions regulating embryonic HSC development. They also engineered a niche that supports HSC maturation in vitro based on this knowledge.
NATURE COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Sarah M. Somers, Jordana Gilbert-Honick, In Young Choi, Emily K. W. Lo, HoTae Lim, Shaquielle Dias, Kathryn R. Wagner, Hai-Quan Mao, Patrick Cahan, Gabsang Lee, Warren L. Grayson
Summary: Tissue engineering strategies combining human pluripotent stem cells and advanced biomaterials can be used to engineer skeletal muscle grafts, providing a model for tissue development and promoting muscle regeneration. In this study, the researchers demonstrated the formation of engineered human skeletal muscle grafts containing multinucleated myotubes using fibrin microfiber bundles and PAX7::GFP-sorted hPDMs, which showed potential for promoting in vivo skeletal muscle regeneration.
BIOENGINEERING-BASEL
(2022)
Article
Biology
A. K. Patel, Ankur Dhanik, Wei Keat Lim, Christina Adler, Min Ni, Yi Wei, Maggie Zhong, Cindy Nguyen, Jun Zhong, Yi-Fen Lu, Gavin Thurston, Lynn Macdonald, Andrew Murphy, Cagan Gurer, Davor Frleta
Summary: Immunodeficient mice reconstituted with a human immune system (HIS mice) are a valuable tool for studying human immune responses to tumors. However, these mice often exhibit sub-optimal immune responses and lack antigen-specific B or T cell memory. In this study, we observed spontaneous regression of human B cell lymphoma Raji in HIS mice. Tumor regression was dependent on CD4+ and CD8+ T cells and resulted in T cell memory. We also found clonal expansion of specific T cell receptors (TCRs) and Raji-specific T cell reactivity in regressing tumors.
COMMUNICATIONS BIOLOGY
(2023)
Review
Cell Biology
Adam M. Heck, Takashi Ishida, Brandon Hadland
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Engineering, Biomedical
Ngan F. Huang, Ovijit Chaudhuri, Patrick Cahan, Aijun Wang, Adam J. Engler, Yingxiao Wang, Sanjay Kumar, Ali Khademhosseini, Song Li
APL BIOENGINEERING
(2020)
