CD200-, CX3CL1-, and TREM2-mediated neuron-microglia interactions and their involvements in Alzheimer’s disease

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

TREM2-Ligand Interactions in Health and Disease

(2017) Daniel L. Kober et al.   JOURNAL OF MOLECULAR BIOLOGY

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

(2017) Shane M. Bemiller et al.   Molecular Neurodegeneration

Neuroinflammation in Alzheimer's Disease: Mechanisms, Pathologic Consequences, and Potential for Therapeutic Manipulation

(2017) Kenneth Hensley   JOURNAL OF ALZHEIMERS DISEASE

Communication in Neural Circuits: Tools, Opportunities, and Challenges

(2016) Talia N. Lerner et al.   CELL

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

(2016) Xianyuan Xiang et al.   EMBO Molecular Medicine

Neuron-microglia interaction induced bi-directional cytotoxicity associated with calpain activation

(2016) Maria Podbielska et al.   JOURNAL OF NEUROCHEMISTRY

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

(2016) Honghua Zheng et al.   NEUROBIOLOGY OF AGING

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Different mechanisms of apolipoprotein E isoform–dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

(2015) Xianwu Li et al.   FASEB JOURNAL

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

(2015) Li Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer’s disease progression: CX3CL1, TREM2, and PPARγ

(2015) S. Strobel et al.   JOURNAL OF NEURAL TRANSMISSION

Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease

(2015) Hong Lian et al.   JOURNAL OF NEUROCHEMISTRY

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

TREM2 in CNS homeostasis and neurodegenerative disease

(2015) Meghan M. Painter et al.   Molecular Neurodegeneration

Finding translation in stress research

(2015) Ahmad R Hariri et al.   NATURE NEUROSCIENCE

The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease

(2015) Megan M. Varnum et al.   NEUROBIOLOGY OF AGING

Microglia in neuronal plasticity: Influence of stress

(2015) Jean-Christophe Delpech et al.   NEUROPHARMACOLOGY

The Potential Role of Chemokines in Alzheimer’s Disease Pathogenesis

(2014) Gholamreza Azizi et al.   American Journal of Alzheimers Disease and Other Dementias

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Brain Innate Immunity in the Regulation of Neuroinflammation: Therapeutic Strategies by Modulating CD200-CD200R Interaction Involve the Cannabinoid System

(2014) Miriam Hernangomez et al.   CURRENT PHARMACEUTICAL DESIGN

Cytokine-Mediated Inhibition of Fibrillar Amyloid-  Peptide Degradation by Human Mononuclear Phagocytes

(2014) M. Yamamoto et al.   JOURNAL OF IMMUNOLOGY

Activation of Neuronal NMDA Receptors Triggers Transient ATP-Mediated Microglial Process Outgrowth

(2014) L. Dissing-Olesen et al.   JOURNAL OF NEUROSCIENCE

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

(2014) Véréna Landel et al.   Molecular Neurodegeneration

Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

(2014) Ilie-Cosmin Stancu et al.   Molecular Neurodegeneration

Circuit dynamics of adaptive and maladaptive behaviour

(2014) Karl Deisseroth   NATURE

Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease

(2014) Cecilia E. Hanzel et al.   NEUROBIOLOGY OF AGING

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

TREM2 and the neuroimmunology of Alzheimer's disease

(2013) Suzanne E. Hickman et al.   BIOCHEMICAL PHARMACOLOGY

NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese

(2013) Meng-Shan Tan et al.   JOURNAL OF NEUROIMMUNOLOGY

TREM2 in Alzheimer’s disease

(2013) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Neuronal Synapse Formation Induced by Microglia and Interleukin 10

(2013) So-Hee Lim et al.   PLoS One

Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage

(2013) G. K. Sheridan et al.   Open Biology

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Variant TREM2 as Risk Factor for Alzheimer's Disease

(2012) Harald Neumann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD200 fusion protein decreases microglial activation in the hippocampus of aged rats

(2011) F. Fionnuala Cox et al.   BRAIN BEHAVIOR AND IMMUNITY

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

(2011) Hiroaki Ito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Long Term Potentiation Is Impaired in Membrane Glycoprotein CD200-deficient Mice

(2011) Derek A. Costello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus

(2011) S.-I. Yeo et al.   JOURNAL OF NEUROIMMUNOLOGY

CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity

(2011) J. T. Rogers et al.   JOURNAL OF NEUROSCIENCE

Microglial Morphology and Dynamic Behavior Is Regulated by Ionotropic Glutamatergic and GABAergic Neurotransmission

(2011) Aurora M. Fontainhas et al.   PLoS One

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

(2010) Sungho Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation

(2010) Heidi A. Jurgens et al.   EXPERIMENTAL NEUROLOGY

CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer’s disease-like pathogenesis in APP+PS1 bigenic mice

(2010) Tomomi Kiyota et al.   FASEB JOURNAL

Fractalkine Attenuates Excito-neurotoxicity via Microglial Clearance of Damaged Neurons and Antioxidant Enzyme Heme Oxygenase-1 Expression

(2010) Mariko Noda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide

(2009) Anthony Lyons et al.   BRAIN BEHAVIOR AND IMMUNITY

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

(2009) Elsa-Noah N'Diaye et al.   JOURNAL OF CELL BIOLOGY

Essential Roles for Dok2 and RasGAP in CD200 Receptor-Mediated Regulation of Human Myeloid Cells

(2009) R. Mihrshahi et al.   JOURNAL OF IMMUNOLOGY

Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation

(2009) Nathalie Koning et al.   Journal of Innate Immunity

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

(2009) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation

(2008) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

(2008) Stefanie Frank et al.   GLIA

Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer's disease

(2008) Tae-Suk Kim et al.   NEUROSCIENCE LETTERS