Leptin Dysfunction and Alzheimer’s Disease: Evidence from Cellular, Animal, and Human Studies

Leptin Reduces Pathology and Improves Memory in a Transgenic Mouse Model of Alzheimer's Disease

(2017) Steven J. Greco et al.   JOURNAL OF ALZHEIMERS DISEASE

Leptin Reduces the Accumulation of Aβ and Phosphorylated Tau Induced by 27-Hydroxycholesterol in Rabbit Organotypic Slices

(2017) Gurdeep Marwarha et al.   JOURNAL OF ALZHEIMERS DISEASE

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

Metabolic and Non-Cognitive Manifestations of Alzheimer’s Disease: The Hypothalamus as Both Culprit and Target of Pathology

(2015) Makoto Ishii et al.   Cell Metabolism

Leptin attenuates the detrimental effects of β-amyloid on spatial memory and hippocampal later-phase long term potentiation in rats

(2015) Jia-qing Tong et al.   HORMONES AND BEHAVIOR

Leptin treatment: Facts and expectations

(2015) Gilberto Paz-Filho et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

(2015) Hyeong-Kyu Park et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Plasma leptin levels and free leptin index in women with Alzheimer's disease

(2015) Agnieszka Baranowska-Bik et al.   NEUROPEPTIDES

BMI and risk of dementia in two million people over two decades: a retrospective cohort study

(2015) Nawab Qizilbash et al.   Lancet Diabetes & Endocrinology

Plasma leptin levels are not predictive of dementia in patients with mild cognitive impairment

(2014) R. Oania et al.   AGE AND AGEING

Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease

(2014) Silvia Maioli et al.   AGING CELL

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway

(2014) Gurdeep Marwarha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Low Plasma Leptin in Cognitively Impaired ADNI Subjects: Gender Differences and Diagnostic and Therapeutic Potential

(2014) Jane Johnston et al.   Current Alzheimer Research

Adipocyte Versus Pituitary Leptin in the Regulation of Pituitary Hormones: Somatotropes Develop Normally in the Absence of Circulating Leptin

(2014) Angela K. Odle et al.   ENDOCRINOLOGY

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Leptin gene therapy attenuates neuronal damages evoked by amyloid-β and rescues memory deficits in APP/PS1 mice

(2014) R Pérez-González et al.   GENE THERAPY

Leptin and aging: Review and questions with particular emphasis on its role in the central regulation of energy balance

(2014) Márta Balaskó et al.   JOURNAL OF CHEMICAL NEUROANATOMY

The neuroanatomical function of leptin in the hypothalamus

(2014) M.M.H. van Swieten et al.   JOURNAL OF CHEMICAL NEUROANATOMY

20 YEARS OF LEPTIN: Leptin at 20: an overview

(2014) Jeffrey Friedman   JOURNAL OF ENDOCRINOLOGY

20 YEARS OF LEPTIN: Connecting leptin signaling to biological function

(2014) Margaret B Allison et al.   JOURNAL OF ENDOCRINOLOGY

Leptin inhibits amyloid β-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway

(2014) Naoki Yamamoto et al.   JOURNAL OF NEUROCHEMISTRY

Protective Effect of Leptin and Ghrelin against Toxicity Induced by Amyloid-β Oligomers in a Hypothalamic cell Line

(2014) S. Gomes et al.   JOURNAL OF NEUROENDOCRINOLOGY

Leptin-Induced Spine Formation Requires TrpC Channels and the CaM Kinase Cascade in the Hippocampus

(2014) M. Dhar et al.   JOURNAL OF NEUROSCIENCE

Transgenic Mice Overexpressing Amyloid Precursor Protein Exhibit Early Metabolic Deficits and a Pathologically Low Leptin State Associated with Hypothalamic Dysfunction in Arcuate Neuropeptide Y Neurons

(2014) M. Ishii et al.   JOURNAL OF NEUROSCIENCE

Adipokines: a link between obesity and dementia?

(2014) Amanda J Kiliaan et al.   LANCET NEUROLOGY

Early Effects of a Hypocaloric, Mediterranean Diet on Laboratory Parameters in Obese Individuals

(2014) Marta Greco et al.   MEDIATORS OF INFLAMMATION

Leptin Induces Hippocampal Synaptogenesis via CREB-Regulated MicroRNA-132 Suppression of p250GAP

(2014) Matasha Dhar et al.   MOLECULAR ENDOCRINOLOGY

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

(2014) Jae Geun Kim et al.   NATURE NEUROSCIENCE

Dietary and lifestyle guidelines for the prevention of Alzheimer's disease

(2014) Neal D. Barnard et al.   NEUROBIOLOGY OF AGING

Ghrelin: A link between ageing, metabolism and neurodegenerative disorders

(2014) I.I. Stoyanova   NEUROBIOLOGY OF DISEASE

Neuroprotective effects of leptin in the context of obesity and metabolic disorders

(2014) Cecilia Davis et al.   NEUROBIOLOGY OF DISEASE

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Adipokines and insulin action

(2014) Alexander J Knights et al.   Adipocyte

Leptin at the Intersection of Neuroendocrinology and Metabolism: Current Evidence and Therapeutic Perspectives

(2013) Maria Dalamaga et al.   Cell Metabolism

Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance

(2013) David J. Bonda et al.   JOURNAL OF NEUROCHEMISTRY

Leptin and ghrelin prevent hippocampal dysfunction induced by Aβ oligomers

(2013) I. Martins et al.   NEUROSCIENCE

Leptin regulation of hippocampal synaptic function in health and disease

(2013) A. J. Irving et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Leptin and dementia over 32 years—The Prospective Population Study of Women

(2012) Deborah R. Gustafson et al.   Alzheimers & Dementia

Leptin action on nonneuronal cells in the CNS: potential clinical applications

(2012) Weihong Pan et al.   Annals of the New York Academy of Sciences

Leptin regulates amyloid β production via the γ-secretase complex

(2012) Dana M. Niedowicz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Challenges and Opportunities of Defining Clinical Leptin Resistance

(2012) Martin G. Myers et al.   Cell Metabolism

Changes in body mass in later life and incident dementia

(2012) Brian D. Power et al.   INTERNATIONAL PSYCHOGERIATRICS

Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

(2012) Thomas G. Beach et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Leptin, Mild Cognitive Impairment, and Dementia Among Elderly Women

(2012) A. Zeki Al Hazzouri et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Leptin revisited: its mechanism of action and potential for treating diabetes

(2012) Roberto Coppari et al.   NATURE REVIEWS DRUG DISCOVERY

Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β

(2012) Gayle H. Doherty et al.   NEUROBIOLOGY OF AGING

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons

(2011) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus

(2011) Gurdeep Marwarha et al.   Molecular Neurodegeneration

Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease

(2011) Michael Ewers et al.   NEUROBIOLOGY OF AGING

Midlife overweight and obesity increase late-life dementia risk: A population-based twin study

(2011) W. L. Xu et al.   NEUROLOGY

Alzheimer disease biomarkers are associated with body mass index

(2011) E. D. Vidoni et al.   NEUROLOGY

NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity

(2011) Peter R. Moult et al.   NEUROPHARMACOLOGY

Adipocytokines and CD34+ Progenitor Cells in Alzheimer's Disease

(2011) Boris Bigalke et al.   PLoS One

β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway

(2010) Gurdeep Marwarha et al.   JOURNAL OF NEUROCHEMISTRY

Accelerated Weight Loss and Incident Dementia in an Elderly African-American Cohort

(2010) Sujuan Gao et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Leptin therapy in insulin-deficient type I diabetes

(2010) M.-y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells

(2009) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overweight in midlife and risk of dementia: a 40-year follow-up study

(2009) L B Hassing et al.   INTERNATIONAL JOURNAL OF OBESITY

Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging

(2009) Wolfgang Lieb   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association between late-life body mass index and dementia: The Kame Project

(2009) T. F. Hughes et al.   NEUROLOGY

Leptin inhibits glycogen synthase kinase-3β to prevent tau phosphorylation in neuronal cells

(2009) Steven J. Greco et al.   NEUROSCIENCE LETTERS

Experimental Diabetes Mellitus Exacerbates Tau Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2009) Yazi D. Ke et al.   PLoS One

Leptin reduces Alzheimer’s disease-related tau phosphorylation in neuronal cells

(2008) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Relationship Between Plasma Leptin Level and Brain Structure in Elderly: A Voxel-Based Morphometric Study

(2008) Kosuke Narita et al.   BIOLOGICAL PSYCHIATRY

Review on leptin and adiponectin responses and adaptations to acute and chronic exercise

(2008) A. Bouassida et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Leptin protects hippocampal CA1 neurons against ischemic injury

(2008) Feng Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Serum leptin level and cognition in the elderly: Findings from the Health ABC Study

(2008) Karen F. Holden et al.   NEUROBIOLOGY OF AGING

High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model

(2008) Carl Julien et al.   NEUROBIOLOGY OF AGING

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Leptin Replacement Improves Cognitive Development

(2008) Gilberto J. Paz-Filho et al.   PLoS One

Making insulin-deficient type 1 diabetic rodents thrive without insulin

(2008) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies

(2008) J. D. Roth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory and Injury Responses to Ischemic Stroke in Obese Mice

(2008) Satoshi Terao et al.   STROKE

Megalin mediates the transport of leptin across the blood-CSF barrier

(2007) Marcelo O. Dietrich et al.   NEUROBIOLOGY OF AGING