Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival

Clinical Significance of Androgen Receptor Splice Variant-7 mRNA Detection in Circulating Tumor Cells of Men With Metastatic Castration-Resistant Prostate Cancer Treated With First- and Second-Line Abiraterone and Enzalutamide

(2017) Emmanuel S. Antonarakis et al.   JOURNAL OF CLINICAL ONCOLOGY

Adenovirus Core Protein VII Downregulates the DNA Damage Response on the Host Genome

(2017) Daphne C. Avgousti et al.   JOURNAL OF VIROLOGY

Real-Time Transferrin-Based PET Detects MYC-Positive Prostate Cancer

(2017) Rahul Aggarwal et al.   MOLECULAR CANCER RESEARCH

Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting

(2016) E S Antonarakis et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis

(2016) Yunfei Wang et al.   Scientific Reports

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

(2015) Yuko Atsumi et al.   Cell Reports

The nuclear γ-H2AX apoptotic ring: implications for cancers and autoimmune diseases

(2014) Stéphanie Solier et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

(2014) Irfan A. Asangani et al.   NATURE

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1

(2013) Aleixo Santiago et al.   MOLECULAR BIOLOGY OF THE CELL

Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents

(2013) H. Yang et al.   MOLECULAR CANCER THERAPEUTICS

TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer

(2013) M. D. Nyquist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overcoming mutation-based resistance to antiandrogens with rational drug design

(2013) Minna D Balbas et al.   eLife

Androgen Receptor Splice Variants Mediate Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cell Lines

(2012) Y. Li et al.   CANCER RESEARCH

Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection

(2012) Heng Yang et al.   CELL CYCLE

Androgen Receptor Splice Variants Activate Androgen Receptor Target Genes and Support Aberrant Prostate Cancer Cell Growth Independent of Canonical Androgen Receptor Nuclear Localization Signal

(2012) Siu Chiu Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the 55-Residue Protein Encoded by the 9S E1A mRNA of Species C Adenovirus

(2012) Matthew S. Miller et al.   JOURNAL OF VIROLOGY

Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth

(2011) David J. Mulholland et al.   CANCER CELL

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

(2011) Brett S. Carver et al.   CANCER CELL

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

(2011) C. Cai et al.   CANCER RESEARCH

Identification of two independent SUMO-interacting motifs in Daxx: Evolutionary conservation from Drosophila to humans and their biochemical functions

(2011) Aleixo Santiago et al.   CELL CYCLE

New Strategies in Metastatic Prostate Cancer: Targeting the Androgen Receptor Signaling Pathway

(2011) G. Attard et al.   CLINICAL CANCER RESEARCH

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

(2011) Charles E Massie et al.   EMBO JOURNAL

Alternatively spliced androgen receptor variants

(2011) Scott M Dehm et al.   ENDOCRINE-RELATED CANCER

Androgen receptor coregulators: Recruitment via the coactivator binding groove

(2011) Dennis J. van de Wijngaart et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Intrinsic disorder in the androgen receptor: identification, characterisation and drugability

(2011) Iain J. McEwan   Molecular BioSystems

Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor

(2010) Raymond J. Andersen et al.   CANCER CELL

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

(2010) Shihua Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

The N Terminus of Adenovirus Type 12 E1A Inhibits Major Histocompatibility Complex Class I Expression by Preventing Phosphorylation of NF- B p65 Ser276 through Direct Binding

(2010) J. Jiao et al.   JOURNAL OF VIROLOGY

Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study

(2010) Howard I Scher et al.   LANCET

Computational analysis and identification of an emergent human adenovirus pathogen implicated in a respiratory fatality

(2010) Christopher M. Robinson et al.   VIROLOGY

A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion-Resistant Growth

(2009) Z. Guo et al.   CANCER RESEARCH

The adenoviral E1A protein displaces corepressors and relieves gene repression by unliganded thyroid hormone receptors in vivo

(2009) Yukiyasu Sato et al.   CELL RESEARCH

Selective Inhibition of CYP17 With Abiraterone Acetate Is Highly Active in the Treatment of Castration-Resistant Prostate Cancer

(2009) Gerhardt Attard et al.   JOURNAL OF CLINICAL ONCOLOGY

Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

(2008) R. Hu et al.   CANCER RESEARCH

Targeting the androgen receptor pathway in prostate cancer

(2008) Yu Chen et al.   CURRENT OPINION IN PHARMACOLOGY

Intrinsic Structural Disorder in Adenovirus E1A: a Viral Molecular Hub Linking Multiple Diverse Processes

(2008) P. Pelka et al.   JOURNAL OF VIROLOGY

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

(2008) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS