Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B

The specific killing effect of matrine on castration-resistant prostate cancer cells by targeting the Akt/FoxO3a signaling pathway

(2017) Shoumin Bai et al.   ONCOLOGY REPORTS

Gastrin Enhances Autophagy and Promotes Gastric Carcinoma Proliferation via Inducing AMPKα

(2017) Zhuang Kun et al.   ONCOLOGY RESEARCH

Elevation of SHARPIN Protein Levels in Prostate Adenocarcinomas Promotes Metastasis and Impairs Patient Survivals

(2017) Hai Huang et al.   PROSTATE

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

(2017) Jean M Mulcahy Levy et al.   eLife

Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed

(2016) Wenjiao Li et al.   AGING CELL

Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury

(2016) Guoqian He et al.   APOPTOSIS

Matrine: Bioactivities and Structural Modifications

(2016) Jiulin Huang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Matrine suppresses invasion of castration-resistant prostate cancer cells by downregulating MMP-2/9 via NF-κB signaling pathway

(2016) Hai Huang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Matrine induces Akt/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells

(2016) Junqing Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

GADD45B mediates podocyte injury in zebrafish by activating the ROS-GADD45B-p38 pathway

(2016) Z Chen et al.   Cell Death & Disease

A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment

(2016) Daniel Nettersheim et al.   Oncotarget

Gadd45b deficiency promotes premature senescence and skin aging

(2016) Andrew Magimaidas et al.   Oncotarget

WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT/GSK3β/β-catenin signaling pathway

(2016) Chen-Xu Ni et al.   Oncotarget

Matrine derivative WM130 inhibits hepatocellular carcinoma by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways

(2015) Liqiang Qian et al.   CANCER LETTERS

Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (bpV(phen)) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes

(2015) Qi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway

(2015) QI LI et al.   ONCOLOGY REPORTS

Matrine Reduces Proliferation of Human Lung Cancer Cells by Inducing Apoptosis and Changing miRNA Expression Profiles

(2014) Yong-Qi Liu et al.   Asian Pacific Journal of Cancer Prevention

Elevated levels of mitochondrion-associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer

(2014) Xianhan Jiang et al.   CANCER

Matrine inhibits proliferation and induces apoptosis of human colon cancer LoVo cells by inactivating Akt pathway

(2014) Shujun Zhang et al.   MOLECULAR BIOLOGY REPORTS

Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patients

(2014) Xianhan Jiang et al.   MOLECULAR CARCINOGENESIS

DNA hypermethylation promotes the low expression of pro-apoptoticBCL2L11associated withBCR-ABL1fusion gene of chronic myeloid leukaemia

(2012) Elisa Leo et al.   BRITISH JOURNAL OF HAEMATOLOGY

Phosphorylation of Atg5 by the Gadd45β–MEKK4-p38 pathway inhibits autophagy

(2012) E Keil et al.   CELL DEATH AND DIFFERENTIATION

International Variation in Prostate Cancer Incidence and Mortality Rates

(2012) Melissa M. Center et al.   EUROPEAN UROLOGY

Abnormal expression of GADD45B in human colorectal carcinoma

(2012) Lisha Wang et al.   Journal of Translational Medicine

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Identification of Growth Arrest and DNA-Damage-Inducible Gene β (GADD45β) as a Novel Tumor Suppressor in Pituitary Gonadotrope Tumors

(2011) Katherine A. Michaelis et al.   ENDOCRINOLOGY

Downregulation of Gadd45β Expression by Hepatitis C Virus Leads to Defective Cell Cycle Arrest

(2010) Martin R. Higgs et al.   CANCER RESEARCH

Update on castrate-resistant prostate cancer: 2010

(2010) Kiran Lassi et al.   CURRENT OPINION IN ONCOLOGY

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

DEGseq: an R package for identifying differentially expressed genes from RNA-seq data

(2009) Likun Wang et al.   BIOINFORMATICS

Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-κB signaling

(2009) Pengfei Yu et al.   CYTOTECHNOLOGY

Lead Time and Overdiagnosis in Prostate-Specific Antigen Screening: Importance of Methods and Context

(2009) G. Draisma et al.   JNCI-Journal of the National Cancer Institute