IL-1β enables CNS access to CCR2himonocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells

Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System

(2017) Sabine Spath et al.   IMMUNITY

Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation

(2017) Yochai Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evolving concepts in the treatment of relapsing multiple sclerosis

(2017) Giancarlo Comi et al.   LANCET

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

(2017) Alyssa Carey et al.   Cell Reports

IL‐1 signaling is critical for expansion but not generation of autoreactive GM‐CSF + Th17 cells

(2016) Ilgiz A Mufazalov et al.   EMBO JOURNAL

Myeloid cell transmigration across the CNS vasculature triggers IL-1β–driven neuroinflammation during autoimmune encephalomyelitis in mice

(2016) Sébastien A. Lévesque et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pivotal Role for CD16+Monocytes in Immune Surveillance of the Central Nervous System

(2016) Anne Waschbisch et al.   JOURNAL OF IMMUNOLOGY

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

(2016) Eric M. Pietras et al.   NATURE CELL BIOLOGY

T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis

(2016) Bradley N Martin et al.   NATURE IMMUNOLOGY

Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells

(2016) Francesca Ronchi et al.   Nature Communications

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

GM-CSF in Neuroinflammation: Licensing Myeloid Cells for Tissue Damage

(2015) Andrew L. Croxford et al.   TRENDS IN IMMUNOLOGY

Interferon-β Suppresses Murine Th1 Cell Function in the Absence of Antigen-Presenting Cells

(2015) Nicolas Boivin et al.   PLoS One

In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed

(2014) I. D. Vainchtein et al.   GLIA

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils Mediate Blood–Spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases

(2014) Benoit Aubé et al.   JOURNAL OF IMMUNOLOGY

GM-CSF-Responsive Monocyte-Derived Dendritic Cells Are Pivotal in Th17 Pathogenesis

(2014) H.-J. Ko et al.   JOURNAL OF IMMUNOLOGY

The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis

(2014) Aline Dumas et al.   PLoS Pathogens

Automated Filtering of Intrinsic Movement Artifacts during Two-Photon Intravital Microscopy

(2013) Denis Soulet et al.   PLoS One

IL-1 and T Helper Immune Responses

(2013) Veronica Santarlasci et al.   Frontiers in Immunology

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis

(2012) Florian Leuschner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability

(2012) Weiquan Zhu et al.   NATURE

Generation of Mature Murine Monocytes from Heterogeneous Bone Marrow and Description of Their Properties

(2011) Alexander Francke et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Caspase-1-Processed Cytokines IL-1  and IL-18 Promote IL-17 Production by    and CD4 T Cells That Mediate Autoimmunity

(2011) S. J. Lalor et al.   JOURNAL OF IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

(2010) Li-Chung Hsu et al.   NATURE IMMUNOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

IL-1R Signaling within the Central Nervous System Regulates CXCL12 Expression at the Blood-Brain Barrier and Disease Severity during Experimental Autoimmune Encephalomyelitis

(2009) E. E. McCandless et al.   JOURNAL OF IMMUNOLOGY

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells

(2007) I. Ifergan et al.   BRAIN