Interferon-β Suppresses Murine Th1 Cell Function in the Absence of Antigen-Presenting Cells

An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction

(2015) Chen Zhu et al.   Nature Communications

Lack of TIM-3 Immunoregulation in Multiple Sclerosis

(2014) L. Yang et al.   JOURNAL OF IMMUNOLOGY

FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS

(2014) Yawei Liu et al.   NATURE MEDICINE

Environmental factors in multiple sclerosis

(2013) Alberto Ascherio   Expert Review of Neurotherapeutics

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

Immunoregulatory Effects of Interferon-β in Suppression of Th17 cells

(2013) Leesa M. Pennell et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Type I Interferons: Beneficial in Th1 and Detrimental in Th17 Autoimmunity

(2012) Robert C. Axtell et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

(2012) Sarah C. Starossom et al.   IMMUNITY

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion

(2012) Manu Rangachari et al.   NATURE MEDICINE

Pharmacology and therapeutic potential of interferons

(2012) Peter M. George et al.   PHARMACOLOGY & THERAPEUTICS

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

(2011) Q. Zhou et al.   BLOOD

IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells

(2011) Cheryl M. Sweeney et al.   BRAIN BEHAVIOR AND IMMUNITY

The Mechanism of Action of Interferon-β in Relapsing Multiple Sclerosis

(2011) Bernd C. Kieseier   CNS DRUGS

Cytokines and effector T cell subsets causing autoimmune CNS disease

(2011) Franziska Petermann et al.   FEBS LETTERS

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

Regulation of effector and memory T-cell functions by type I interferon

(2011) Jonathan P. Huber et al.   IMMUNOLOGY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Excessive Biologic Response to IFNβ Is Associated with Poor Treatment Response in Patients with Multiple Sclerosis

(2011) Richard A. Rudick et al.   PLoS One

T-bet, a Th1 transcription factor regulates the expression of Tim-3

(2010) Ana C. Anderson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Current Views on the Roles of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2010) Mohamed El-behi et al.   Journal of Neuroimmune Pharmacology

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

IFN-  Inhibits Human Th17 Cell Differentiation

(2009) V. S. Ramgolam et al.   JOURNAL OF IMMUNOLOGY

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Encephalitogenicity of Complete Freund's Adjuvant Relative to CpG Is Linked to Induction of Th17 Cells

(2009) J. T. Tigno-Aranjuez et al.   JOURNAL OF IMMUNOLOGY

Beta interferons in clinically isolated syndromes: a meta-analysis

(2008) Ailton Melo et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Engagement of the Type I Interferon Receptor on Dendritic Cells Inhibits T Helper 17 Cell Development: Role of Intracellular Osteopontin

(2008) Mari L. Shinohara et al.   IMMUNITY

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

(2008) Marco Prinz et al.   IMMUNITY

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

(2008) Beichu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE