Myeloid cell transmigration across the CNS vasculature triggers IL-1β–driven neuroinflammation during autoimmune encephalomyelitis in mice

Neutrophil-related factors as biomarkers in EAE and MS

(2015) Julie M. Rumble et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-1  Gene Deletion Protects Oligodendrocytes after Spinal Cord Injury through Upregulation of the Survival Factor Tox3

(2015) D. Bastien et al.   JOURNAL OF NEUROSCIENCE

Interleukin 1 Type 1 Receptor Restore: A Genetic Mouse Model for Studying Interleukin 1 Receptor-Mediated Effects in Specific Cell Types

(2015) X. Liu et al.   JOURNAL OF NEUROSCIENCE

Neutrophil Priming Occurs in a Sequential Manner and Can Be Visualized in Living Animals by Monitoring IL-1β Promoter Activation

(2014) Yi Yao et al.   JOURNAL OF IMMUNOLOGY

Neutrophils Mediate Blood–Spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases

(2014) Benoit Aubé et al.   JOURNAL OF IMMUNOLOGY

RNA sequencing of microglia and monocyte-derived macrophages from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course

(2014) Nuruddeen D. Lewis et al.   JOURNAL OF NEUROIMMUNOLOGY

Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset

(2014) Dario Seppi et al.   JOURNAL OF NEUROIMMUNOLOGY

Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells

(2013) H. Matsushima et al.   BLOOD

Emergence, origin, and function of neutrophil-dendritic cell hybrids in experimentally induced inflammatory lesions in mice

(2013) S. Geng et al.   BLOOD

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Neutrophils Amplify Autoimmune Central Nervous System Infiltrates by Maturing Local APCs

(2013) K. Steinbach et al.   JOURNAL OF IMMUNOLOGY

Automated Filtering of Intrinsic Movement Artifacts during Two-Photon Intravital Microscopy

(2013) Denis Soulet et al.   PLoS One

Characteristic Cerebrospinal Fluid Cytokine/Chemokine Profiles in Neuromyelitis Optica, Relapsing Remitting or Primary Progressive Multiple Sclerosis

(2013) Takuya Matsushita et al.   PLoS One

Interleukin-1α

(2013) Peleg Rider et al.   SEMINARS IN IMMUNOLOGY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo

(2012) Doris Proebstl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammasome-Derived IL-1  Regulates the Production of GM-CSF by CD4+ T Cells and    T Cells

(2012) J. R. Lukens et al.   JOURNAL OF IMMUNOLOGY

CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis

(2012) Monica Roy et al.   Journal of Neuroinflammation

P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury

(2012) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

An artery-specific fluorescent dye for studying neurovascular coupling

(2012) Zhiming Shen et al.   NATURE METHODS

Brain microvascular pericytes in health and disease

(2011) Turgay Dalkara et al.   ACTA NEUROPATHOLOGICA

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Role for MyD88, TLR2 and TLR9 but Not TLR1, TLR4 or TLR6 in Experimental Autoimmune Encephalomyelitis

(2011) S. Miranda-Hernandez et al.   JOURNAL OF IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

The blood–brain barrier, chemokines and multiple sclerosis

(2010) David W. Holman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sickness behaviour is induced by a peripheral CXC-chemokine also expressed in Multiple Sclerosis and EAE

(2010) Sandra J. Campbell et al.   BRAIN BEHAVIOR AND IMMUNITY

Endothelial IL-1R1 is a critical mediator of EAE pathogenesis

(2010) Qiming Li et al.   BRAIN BEHAVIOR AND IMMUNITY

EAE mediated by a non-IFN-γ/non-IL-17 pathway

(2010) Mark A. Kroenke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intravital Imaging of IL-1β Production in Skin

(2010) Hironori Matsushima et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

(2010) Sussan Nourshargh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

CNS pericytes: Concepts, misconceptions, and a way out

(2009) Martin Krueger et al.   GLIA

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

IL-1R Signaling within the Central Nervous System Regulates CXCL12 Expression at the Blood-Brain Barrier and Disease Severity during Experimental Autoimmune Encephalomyelitis

(2009) E. E. McCandless et al.   JOURNAL OF IMMUNOLOGY

Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid

(2009) J. Mellergård et al.   Multiple Sclerosis Journal

Pathological Expression of CXCL12 at the Blood-Brain Barrier Correlates with Severity of Multiple Sclerosis

(2008) Erin E. McCandless et al.   AMERICAN JOURNAL OF PATHOLOGY

Gene Expression of Endothelial Cells due to Interleukin-1 Beta Stimulation and Neutrophil Transmigration

(2008) Marcie R. Williams et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH

The Th17–ELR+CXC chemokine pathway is essential for the development of central nervous system autoimmune disease

(2008) Thaddeus Carlson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition

(2008) Mark A. Kroenke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requirement of Myeloid Cells for Axon Regeneration

(2008) B. Barrette et al.   JOURNAL OF NEUROSCIENCE

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells

(2007) I. Ifergan et al.   BRAIN