Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

Fibulin-4 reduces extracellular matrix production and suppresses chondrocyte differentiation via DKK1- mediated canonical Wnt/β-catenin signaling

(2017) Lei Shangguan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension

(2017) Daniel Owusu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

(2017) Helen R Warren et al.   NATURE GENETICS

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

(2017) Jingjing Liang et al.   PLoS Genetics

Multiple Mechanisms are Involved in Salt-Sensitive Hypertension-Induced Renal Injury and Interstitial Fibrosis

(2017) Shi-Yao Wei et al.   Scientific Reports

Transcription-coupled homologous recombination after oxidative damage

(2016) Leizhen Wei et al.   DNA REPAIR

An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group

(2016) Yun Ju Sung et al.   GENETIC EPIDEMIOLOGY

Alcoholic cardiomyopathy

(2016) B. Maisch   HERZ

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Mohammad H Forouzanfar et al.   LANCET

Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study

(2016) Martin J O'Donnell et al.   LANCET

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

(2016) Chunyu Liu et al.   NATURE GENETICS

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

(2016) Praveen Surendran et al.   NATURE GENETICS

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

(2016) Georg B Ehret et al.   NATURE GENETICS

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

(2016) Thomas J Hoffmann et al.   NATURE GENETICS

Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders

(2016) Min-Tzu Lo et al.   NATURE GENETICS

The prosurvival protein BAG3: a new participant in vascular homeostasis

(2016) Albino Carrizzo et al.   Cell Death & Disease

Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index

(2016) Alexander I. Young et al.   Nature Communications

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

A gene-based association method for mapping traits using reference transcriptome data

(2015) Eric R Gamazon et al.   NATURE GENETICS

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress

(2015) Patrícia Passaglia et al.   VASCULAR PHARMACOLOGY

Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci

(2014) Vinicius Tragante et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GRASP: analysis of genotype-phenotype results from 1390 genome-wide association studies and corresponding open access database

(2014) R. Leslie et al.   BIOINFORMATICS

Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families

(2014) Manav Kapoor et al.   DRUG AND ALCOHOL DEPENDENCE

Thyroid Disease and the Cardiovascular System

(2014) Sara Danzi et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Pleiotropic genes for metabolic syndrome and inflammation

(2014) Aldi T. Kraja et al.   MOLECULAR GENETICS AND METABOLISM

Comparative analysis of regulatory information and circuits across distant species

(2014) Alan P. Boyle et al.   NATURE

Whole-genome haplotyping using long reads and statistical methods

(2014) Volodymyr Kuleshov et al.   NATURE BIOTECHNOLOGY

Quality control and conduct of genome-wide association meta-analyses

(2014) Thomas W Winkler et al.   Nature Protocols

A Gene-Based Analysis of Variants in the Serum/Glucocorticoid Regulated Kinase (SGK) Genes with Blood Pressure Responses to Sodium Intake: The GenSalt Study

(2014) Changwei Li et al.   PLoS One

Adolescent, but Not Adult, Binge Ethanol Exposure Leads to Persistent Global Reductions of Choline Acetyltransferase Expressing Neurons in Brain

(2014) Ryan P. Vetreno et al.   PLoS One

ALDH2is associated to alcohol dependence and is the major genetic determinant of “daily maximum drinks” in a GWAS study of an isolated rural chinese sample

(2013) Ellen E. Quillen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

A Genome-Wide Association Study of Behavioral Disinhibition

(2013) Matt McGue et al.   BEHAVIOR GENETICS

Genetic Variation in the Atrial Natriuretic Peptide Transcription Factor GATA4 Modulates Amygdala Responsiveness in Alcohol Dependence

(2013) Anne Jorde et al.   BIOLOGICAL PSYCHIATRY

DNA-Binding Specificities of Human Transcription Factors

(2013) Arttu Jolma et al.   CELL

Dynamic trans-Acting Factor Colocalization in Human Cells

(2013) Dan Xie et al.   CELL

Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study

(2013) D. A. Lawlor et al.   EUROPEAN HEART JOURNAL

Loci influencing blood pressure identified using a cardiovascular gene-centric array

(2013) Santhi K. Ganesh, Vinicius Tragante, Wei Guo, Yiran Guo, Matthew B. Lanktree, Erin N. Smith, Toby Johnson, Berta Almoguera Castillo, John Barnard, Jens Baumert, Yen-Pei Christy Chang, Clara C. Elbers, Martin Farrall, Mary E. Fischer, Nora Franceschini, Tom R. Gaunt, Johannes M.I.H. Gho, Christian Gieger, Yan Gong, Aaron Isaacs, Marcus E. Kleber, Irene Mateo Leach, Caitrin W. McDonough, Matthijs F.L. Meijs, Olle Mellander, Cliona M. Molony, Ilja M. Nolte, Sandosh Padmanabhan, Tom S. Price, Ramakrishnan Rajagopalan, Jonathan Shaffer, Sonia Shah, Haiqing Shen, Nicole Soranzo, Peter J. van der Most, Erik P.A. Van Iperen, Jessic A. Van Setten, Judith M. Vonk, Li Zhang, Amber L. Beitelshees, Gerald S. Berenson, Deepak L. Bhatt, Jolanda M.A. Boer, Eric Boerwinkle, Ben Burkley, Amber Burt, Aravinda Chakravarti, Wei Chen, Rhonda M. Cooper-DeHoff, Sean P. Curtis, Albert Dreisbach, David Duggan, Georg B. Ehret, Richard R. Fabsitz, Myriam Fornage, Ervin Fox, Clement E. Furlong, Ron T. Gansevoort, Marten H. Hofker, G. Kees Hovingh, Susan A. Kirkland, Kandice Kottke-Marchant, Abdullah Kutlar, Andrea Z. LaCroix, Taimour Y. Langaee, Yun R. Li, Honghuang Lin, Kiang Liu, Steffi Maiwald, Rainer Malik, Gurunathan Murugesan, Christopher Newton-Cheh, Jeffery R. O'Connell, N. Charlotte Onland-Moret, Willem H. Ouwehand et al.   HUMAN MOLECULAR GENETICS

Cause-specific telomere factors deregulation in hepatocellular carcinoma

(2013) Manale El Idrissi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Association of rare PTP4A1-PHF3-EYS variants with alcohol dependence

(2013) Lingjun Zuo et al.   JOURNAL OF HUMAN GENETICS

Genetic Variants in the Fat Mass- and Obesity-Associated (FTO) Gene are Associated with Alcohol Dependence

(2013) Liang Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci

(2013) J Gelernter et al.   MOLECULAR PSYCHIATRY

Transcriptome and genome sequencing uncovers functional variation in humans

(2013) Tuuli Lappalainen et al.   NATURE

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Ethanol Regulation of Serum Glucocorticoid Kinase 1 Expression in DBA2/J Mouse Prefrontal Cortex

(2013) Blair N. Costin et al.   PLoS One

Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9

(2013) Jeannette Simino et al.   Frontiers in Genetics

Association ofGATA4sequence variation with alcohol dependence

(2012) Victor M. Karpyak et al.   ADDICTION BIOLOGY

MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholics

(2012) Rosemarie Kryger et al.   ALCOHOL

Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population

(2012) Neelanjana Roy et al.   GENE

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population

(2012) Hyun-Kyung Park et al.   MOLECULAR BIOLOGY REPORTS

DNase I sensitivity QTLs are a major determinant of human expression variation

(2012) Jacob F. Degner et al.   NATURE

Statistical and Biological Gene-Lifestyle Interactions of MC4R and FTO with Diet and Physical Activity on Obesity: New Effects on Alcohol Consumption

(2012) Dolores Corella et al.   PLoS One

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

(2011) Eric Villard et al.   EUROPEAN HEART JOURNAL

Mapping and analysis of chromatin state dynamics in nine human cell types

(2011) Jason Ernst et al.   NATURE

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

(2011) L. D. Ward et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Association Study of Alcohol Dependence Implicates a Region on Chromosome 11

(2010) Howard J. Edenberg et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

A Comparison of Sample Size and Power in Case-Only Association Studies of Gene-Environment Interaction

(2010) G. M. Clarke et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

ProbABEL package for genome-wide association analysis of imputed data

(2010) Yurii S Aulchenko et al.   BMC BIOINFORMATICS

Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients

(2010) Alisa K. Manning et al.   GENETIC EPIDEMIOLOGY

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate

(2010) F Kiefer et al.   PHARMACOGENOMICS JOURNAL

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

(2010) André Scherag et al.   PLoS Genetics

Genome-wide Association Study of Alcohol Dependence

(2009) Jens Treutlein et al.   ARCHIVES OF GENERAL PSYCHIATRY

Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms inERCC5,ERCC6andRAD23Bbut not by polymorphisms in five other nucleotide excision repair genes

(2009) Rashda Abbasi et al.   INTERNATIONAL JOURNAL OF CANCER

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS