Article
Cell Biology
Gilson P. Dorneles, Paula C. Teixeira, Igor M. da Silva, Lucas L. Schipper, Paulo C. Santana Filho, Luiz C. Rodrigues Junior, Cristina Bonorino, Alessandra Peres, Simone G. Fonseca, Marta C. Monteiro, Carina R. Boeck, Sarah Eller, Tiago F. Oliveira, Eliana M. Wendland, Pedro R. T. Romao
Summary: This study investigates alterations in purinergic pathways in COVID-19 patients and provides new insights into the immunopathology of the disease. The findings suggest that the purinergic signaling is dysregulated in both mild and severe COVID-19 patients, which may affect immune function. Additionally, increased T-cell apoptosis and decreased purine levels are observed in COVID-19 patients compared to healthy controls.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Lydia Meziani, Marine Gerbe de Thore, Celine Clemenson, Winchygn Liu, Pierre-Antoine Laurent, Michele Mondini, Marie-Catherine Vozenin, Eric Deutsch
Summary: CD73 targeting can improve the antitumor effects of irradiation and immune checkpoint inhibitor treatment, and the dosing regimen and iCOS expression are important factors that affect the therapeutic efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Orthopedics
Andrew Hinkle, Celeste Quitiquit Dickason, Thomas Jinguji, Susan Shenoi, Mahesh Thapa, Michael G. Saper, Viviana Bompadre, Gregory A. Schmale
Summary: In patients with JIA, OCD lesions are significantly more prevalent and often present at an advanced stage, requiring surgical intervention for stabilization or symptom relief.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Immunology
Federica Raggi, Martina Bartolucci, Davide Cangelosi, Chiara Rossi, Simone Pelassa, Chiara Trincianti, Andrea Petretto, Giovanni Filocamo, Adele Civino, Alessandra Eva, Angelo Ravelli, Alessandro Consolaro, Maria Carla Bosco
Summary: This study provides the first detailed longitudinal characterization of the EV-proteome in OJIA patients and identifies a panel of deregulated EV-prots that may serve as early molecular indicators for OJIA development, with potential diagnostic and therapeutic value.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Yo-Ping Lai, Lu-Cheng Kuo, Been-Ren Lin, Hung-Ju Lin, Chih-Yu Lin, Yi-Ting Chen, Pei-Wen Hsiao, Huan-Tsung Chang, Patrick Chow-In Ko, Hsiao-Chin Chen, Hsiang-Yu Chang, Jean Lu, Hong-Nerng Ho, Betty A. Wu-Hsieh, John T. Kung, Shu-Ching Chen
Summary: CD28 costimulation inhibits CD73 upregulation in CD8(+) T cells, thereby preventing them from becoming suppressive. Lack of CD28 costimulation renders CD8(+) T cells immunosuppressive and less effective in eliminating solid tumors.
COMMUNICATIONS BIOLOGY
(2021)
Review
Rheumatology
Napapas Yothakol, Sirirat Charuvanij, Palanan Siriwanarangsun, Pisit Lertwanich, Sorranart Muangsomboon, Maynart Sukharomana
Summary: Synovial osteochondromatosis is an extremely rare benign condition in children and adolescents, characterized by joint pain. It should be considered in the differential diagnosis for children presenting with initial musculoskeletal symptoms, and appropriate radiographic evaluation is necessary for accurate diagnosis. A multidisciplinary team approach is crucial for managing patients with synovial osteochondromatosis.
CLINICAL RHEUMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Iwona Sudol-Szopinska, Nele Herregods, Andrea S. Doria, Mihra S. Taljanovic, Piotr Gietka, Nikolay Tzaribachev, Andrea Sabine Klauser
Summary: Over the past decade, imaging techniques for inflammatory arthritis in juvenile arthropathies have significantly improved, allowing for more accurate assessment and diagnosis. Ultrasound and magnetic resonance imaging have seen advancements in resolution, sensitivity, and diagnostic possibilities.
Article
Immunology
Anna Vanni, Alessio Mazzoni, Roberto Semeraro, Manuela Capone, Patrick Maschmeyer, Giulia Lamacchia, Lorenzo Salvati, Alberto Carnasciali, Parham Farahvachi, Teresa Giani, Gabriele Simonini, Giovanni Filocamo, Micol Romano, Francesco Liotta, Mir-Farzin Mashreghi, Lorenzo Cosmi, Rolando Cimaz, Alberto Magi, Laura Maggi, Francesco Annunziato
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition in childhood, with T cells playing a key role in its pathogenesis. The expression of PD-1 on CD4+ and CD8+ T cells in JIA indicates their active contribution in sustaining chronic inflammation. Targeting PD-1 could be an effective therapeutic strategy for JIA.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Renata Puppin Zandonadi
Summary: Nutrition plays a crucial role in the treatment, health, and life of patients with juvenile idiopathic arthritis (JIA). Suboptimal nutrition can adversely affect the long-term outcome of JIA patients, while correct nutritional status helps with recovery and inflammation reduction.
Article
Biochemistry & Molecular Biology
Rebecca Sohn, Marius Junker, Andrea Meurer, Frank Zaucke, Rainer H. Straub, Zsuzsa Jenei-Lanzl
Summary: The study showed that synoviocytes of OA and RA patients have the ability to synthesize adenosine/inosine, with adenosine predominantly responsible for the anti-inflammatory effects. Inhibiting CD73 increased IL-6 and decreased IL-10, while inhibiting ADA reduced IL-6 and induced IL-10. A(2A)- and A(2B)AR play a crucial role in mediating anti-inflammatory or pro-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Monika Ostrowska, Piotr Gietka, Malgorzata Manczak, Emil Michalski, Iwona Sudol-Szopinska
Summary: The study aimed to differentiate between hip arthritis in JIA and hip arthralgia of unknown etiology using MRI. MRI is effective in distinguishing between the two conditions, with good specificity in confirming a diagnosis of JIA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Maria Francesca Gicchino, Pierluigi Marzuillo, Sarah Zarrilli, Rosa Melone, Stefano Guarino, Emanuele Miraglia Del Giudice, Alma Nunzia Olivieri, Anna Di Sessa
Summary: Juvenile idiopathic arthritis (JIA) has been associated with metabolic impairments, and uric acid (UA) may serve as a useful marker for cardiometabolic risk and disease severity in children with JIA.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Saverio La Bella, Marta Rinaldi, Armando Di Ludovico, Giulia Di Donato, Giulio Di Donato, Vincenzo Salpietro, Francesco Chiarelli, Luciana Breda
Summary: This review evaluates the current understanding of the pathogenesis of JIA subtypes by examining the most relevant and up-to-date evidence. Despite significant improvements over the past decade, the exact cause and molecular mechanisms of JIA remain unclear. Complex interactions between genetic background and environmental factors, as well as the involvement of HLA haplotypes and non-HLA genes, contribute to the abnormal activation of immune cells and the inflammatory process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rheumatology
Soren Lomholt, Malthe Jessen Pedersen, Mia Glerup, Tue Wenzel Kragstrup
Summary: This scoping review aimed to summarize the current knowledge on synovial fibroblasts and their potential involvement in the pathogenesis of juvenile idiopathic arthritis. The review identified several mechanisms and characteristics of synovial fibroblasts that may contribute to disease traits in juvenile idiopathic arthritis. However, the limited number of studies highlights the need for further research in this area.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Pediatrics
Carlos Zozaya, Niloofar Ganji, Bo Li, Maarten Janssen Lok, Carol Lee, Yuhki Koike, Estelle Gauda, Martin Offringa, Simon Eaton, Prakeshkumar S. Shah, Agostino Pierro
Summary: This study assessed the feasibility and safety of remote ischaemic conditioning (RIC) in preterm infants with suspected or confirmed NEC. The results showed that RIC was feasible and safe in these patients, which is of significance for designing future clinical trials.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Rheumatology
Meredyth G. Ll Wilkinson, Dale Moulding, Thomas C. R. McDonnell, Michael Orford, Chris Wincup, Joanna Y. J. Ting, Georg W. Otto, Restuadi Restuadi, Daniel Kelberman, Charalampia Papadopoulou, Sergi Castellano, Simon Eaton, Claire T. Deakin, Elizabeth C. Rosser, Lucy R. Wedderburn
Summary: This study identifies a novel pathway in which altered mitochondrial biology in CD14+ monocytes of Juvenile dermatomyositis (JDM) patients leads to the production of oxidized mitochondrial DNA (oxmtDNA) and stimulates the expression of interferon (IFN) type 1 signature genes. Targeting this pathway has therapeutic potential in JDM and other IFN type 1-driven autoimmune diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pediatrics
Ian Howard Jones, Denise Tao, Bhumita Vagdama, Michael Orford, Simon Eaton, Jane Collins, Nigel John Hall
Summary: Remote ischaemic conditioning (RIC) has therapeutic potential for intestinal diseases in the newborn by reducing the extent and severity of bowel injury and decreasing neutrophil infiltration/activation.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Letter
Pediatrics
Alexandra Stewart, Christina H. Smith, Jo Wray
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Critical Care Medicine
Gareth A. L. Jones, Simon Eaton, Michael Orford, Samiran Ray, Daisy Wiley, Padmanabhan Ramnarayan, David Inwald, Michael P. W. Grocott, Michael Griksaitis, John Pappachan, Lauran R. O'Neill, Paul A. Mouncey, David M. Harrison, Kathryn J. Rowan, Mark Peters
Summary: The study aimed to compare the effects of conservative oxygenation targets and liberal oxygenation targets on the oxidative status of pediatric patients in the intensive care unit. The results showed that the conservative oxygenation group had higher levels of urinary nitrate/nitrite and lower expression of hypoxia-inducible factor (HIF)-1a mRNA in blood.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Neurosciences
Jenny Lange, Olivia Gillham, Michael Flower, Heather Ging, Simon Eaton, Sneha Kapadia, Andreas Neueder, Michael R. Duchen, Patrizia Ferretti, Sarah J. Tabrizi
Summary: Huntington's Disease is a neurodegenerative disease caused by a genetic mutation. Astrocyte dysfunction, specifically changes in gene expression and metabolic activity, plays a role in the pathogenesis of the disease. Additionally, all Huntington's Disease astrocytes exhibit increased DNA damage and a DNA damage response, suggesting a potential mechanism for their dysfunction.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Maria Chorozoglou, Isabel Reading, Simon Eaton, Shehryer Naqvi, Caroline Pardy, Keren Sloan, Christina Major, Natasha Demellweek, Nigel J. Hall
Summary: We conducted a health economic sub-study to compare the non-operative treatment pathway with surgery for uncomplicated acute appendicitis in children. Our objectives were to assess data collection tools and methods, determine indicative costs and benefits, and evaluate the feasibility of conducting a full economic evaluation.
QUALITY OF LIFE RESEARCH
(2023)
Article
Medicine, General & Internal
Ravi Jagatia, Ewald J. Doornebal, Una Rastovic, Nicola Harris, Moyosoreoluwa Feyide, Anabel Martinez Lyons, Rosa Miquel, Yoh Zen, Ane Zamalloa, Farooq Malik, Andreas Prachalias, Krishna Menon, Luke Boulter, Simon Eaton, Nigel Heaton, Sandra Phillips, Shilpa Chokshi, Elena Palma
Summary: In this study, patient-specific immunocompetent disease models of primary liver cancer (PLC) were created using precision-cut tissue slices (PCTS) derived from resected tumors, which effectively captured the multifaceted and intricate heterogeneity of the tumor and its microenvironment. The PCTS model maintained tissue architecture and tumor-specific immunophenotype, making it a robust preclinical tool for investigating immunotherapeutic drug efficacy and non-responsiveness.
Article
Pediatrics
Athanasios Tyraskis, Joseph Davidson, Jennifer Billington, Simon Blackburn, Joseph Curry, Dhanya Mullassery, Stefano Giuliani, Simon Eaton, Kate Cross, Paolo De Coppi
Summary: The purpose of this study was to identify markers of previous ovarian torsion and assess the outcomes according to ultrasound appearance and operative management. The study found that simple cysts have a higher rate of spontaneous regression and ovarian preservation, while complex cysts are more likely to require operative treatment. The presence of fluid-debris level in complex cysts is significantly associated with ovarian loss. Therefore, ultrasound examination and operative treatment are crucial for identifying and managing ovarian torsion.
PEDIATRIC SURGERY INTERNATIONAL
(2023)
Meeting Abstract
Rheumatology
Meredyth G. L. L. Wilkinson, Dale Moulding, Thomas C. R. McDonnell, Mi-Chael Orford, Chris Wincup, Joanna Ting, Georg Otto, Daniel Kelberman, Sergi Castellano, Simon Eaton, Claire T. Deakin, Elizabeth C. Rosser, Lucy R. Wedderburn
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Claire T. Deakin, John Bowes, Lisa G. Rider, Frederick W. Miller, Lauren M. Pachman, Helga Sanner, Kelly Rouster-Stevens, Gulnara Mamyrova, Rodolfo Curiel, Brian M. Feldman, Adam M. Huber, Ann M. Reed, Heinrike Schmeling, Charlotte G. Cook, Lucy R. Marshall, Meredyth G. Ll. Wilkinson, Stephen Eyre, Soumya Raychaudhuri, Lucy R. Wedderburn
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Surgery
Omid Madadi-Sanjani, Joachim F. Kuebler, Julia Brendel, Soeren Wiesner, Annika Mutanen, Simon Eaton, Anja Domenghino, Pierre-Alain Clavien, Benno M. Ure
Summary: To address the inconsistent definitions of surgical complications and unexpected events, a multidisciplinary expert group modified the Clavien-Dindo classification and introduced the Clavien-Madadi classification, which includes organizational and management errors. Unexpected events were documented in a cohort of 17,502 children undergoing surgery and compared with procedure complexity. The results showed that the Clavien-Madadi classification identified additional events and had a higher correlation with procedure complexity.
BRITISH JOURNAL OF SURGERY
(2023)
Letter
Surgery
Barbora Patkova, Anna Svenningsson, Markus Almstroem, Jan F. Svensson, Staffan Eriksson, Tomas Wester, Simon Eaton
Meeting Abstract
Surgery
F. Chang, A. Vaitkute, M. Attrill, S. Chong, H. Mahdi, P. Blair, A. Salama, C. Mauri, S. Eaton, M. Bajaj-Elliott, A. Pesenacker, R. Motallebzadeh
BRITISH JOURNAL OF SURGERY
(2023)