Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation

HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion

(2015) Emily N. Pawlak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

AP-2 Is the Crucial Clathrin Adaptor Protein for CD4 Downmodulation by HIV-1 Nef in Infected Primary CD4+T Cells

(2015) Marcos Vinicius Gondim et al.   JOURNAL OF VIROLOGY

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

(2015) Yoshiko Usami et al.   NATURE

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

(2015) Annachiara Rosa et al.   NATURE

CD4 mimetics sensitize HIV-1-infected cells to ADCC

(2015) Jonathan Richard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo analysis of Nef’s role in HIV-1 replication, systemic T cell activation and CD4+ T cell loss

(2015) Richard L Watkins et al.   Retrovirology

Cargo adaptors: structures illuminate mechanisms regulating vesicle biogenesis

(2015) Jon E. Paczkowski et al.   TRENDS IN CELL BIOLOGY

The Accessory Factor Nef Links HIV-1 to Tec/Btk Kinases in an Src Homology 3 Domain-dependent Manner

(2014) Sreya Tarafdar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment

(2014) John Jeff Alvarado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2

(2014) Tram NQ Pham et al.   Retrovirology

How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

(2014) Xuefeng Ren et al.   eLife

Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity

(2013) Lori A. Emert-Sedlak et al.   CHEMISTRY & BIOLOGY

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes

(2012) Wei Zou et al.   Retrovirology

Role of the CD4 Down-Modulation Activity of Nef in HIV-1 Infectivity

(2011) Margherita Doria   CURRENT HIV RESEARCH

The CD4C/HIVNef Transgenic Model of AIDS

(2011) Paul Jolicoeur   CURRENT HIV RESEARCH

Interactions of the HIV/SIV Pathogenicity Factor Nef with SH3 Domain-Containing Host Cell Proteins

(2011) Kalle Saksela   CURRENT HIV RESEARCH

Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes

(2010) Richard D Sloan et al.   Retrovirology

HIV-1 Nef Dimerization Is Required for Nef-Mediated Receptor Downregulation and Viral Replication

(2009) Jerrod A. Poe et al.   JOURNAL OF MOLECULAR BIOLOGY

A Basic Patch on  -Adaptin Is Required for Binding of Human Immunodeficiency Virus Type 1 Nef and Cooperative Assembly of a CD4-Nef-AP-2 Complex

(2009) R. Chaudhuri et al.   JOURNAL OF VIROLOGY

Bimolecular Fluorescence Complementation (BiFC) Analysis as a Probe of Protein Interactions in Living Cells

(2008) Tom K. Kerppola   Annual Review of Biophysics

HIV-1 Nef: at the crossroads

(2008) John L Foster et al.   Retrovirology

HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

(2008) Malinda R. Schaefer et al.   PLoS Pathogens