Mammalian cold TRP channels: impact on thermoregulation and energy homeostasis

Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice

(2018) Alfonso Reimúndez et al.   JOURNAL OF NEUROSCIENCE

Dawning of a new era in TRP channel structural biology by cryo-electron microscopy

(2018) M. Gregor Madej et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cellular populations and thermosensing mechanisms of the hypothalamic thermoregulatory center

(2018) Jan Siemens et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Optimal housing temperatures for mice to mimic the thermal environment of humans: An experimental study

(2018) Alexander W. Fischer et al.   Molecular Metabolism

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters

(2017) Vanessa Matos-Cruz et al.   Cell Reports

Cold Temperature Encoding by Cutaneous TRPA1 and TRPM8-Carrying Fibers in the Mouse

(2017) Zoltan Winter et al.   Frontiers in Molecular Neuroscience

The significance of beige and brown fat in humans

(2017) Florian W Kiefer   Endocrine Connections

Allosterism and Structure in Thermally Activated Transient Receptor Potential Channels

(2016) Ignacio Diaz-Franulic et al.   Annual Review of Biophysics

Central neural control of thermoregulation and brown adipose tissue

(2016) Shaun F. Morrison   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Warm-Sensitive Neurons that Control Body Temperature

(2016) Chan Lek Tan et al.   CELL

New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives

(2016) Stéphane Lolignier et al.   JOURNAL OF NEUROSCIENCE

TRPA1 channels: molecular sentinels of cellular stress and tissue damage

(2016) Félix Viana   JOURNAL OF PHYSIOLOGY-LONDON

The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia

(2016) K. Song et al.   SCIENCE

Structure of the full-length TRPV2 channel by cryo-EM

(2016) Kevin W. Huynh et al.   Nature Communications

Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects

(2016) Stéphanie Michlig et al.   Scientific Reports

Erratum: Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

ThermoTRPs and Pain

(2015) Robyn J Laing et al.   NEUROSCIENTIST

Potential therapeutic value of TRPV1 and TRPA1 in diabetes mellitus and obesity

(2015) Andrei V. Derbenev et al.   Seminars in Immunopathology

TRPA1 mediates the hypothermic action of acetaminophen

(2015) Clive Gentry et al.   Scientific Reports

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

(2015) Susana Camacho et al.   Scientific Reports

Integration of body temperature into the analysis of energy expenditure in the mouse

(2015) Gustavo Abreu-Vieira et al.   Molecular Metabolism

Skin temperature: its role in thermoregulation

(2014) A. A. Romanovsky   Acta Physiologica

Brite/beige fat and UCP1 — is it thermogenesis?

(2014) Susanne Keipert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Resiniferatoxin Mediated Ablation of TRPV1+ Neurons Removes TRPA1 as Well

(2014) László Pecze et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

A Molecular Framework for Temperature-Dependent Gating of Ion Channels

(2014) Sandipan Chowdhury et al.   CELL

The TRPM8 Protein Is a Testosterone Receptor

(2014) Swapna Asuthkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Receptor Potential Channel Ankyrin-1 Is Not a Cold Sensor for Autonomic Thermoregulation in Rodents

(2014) C. de Oliveira et al.   JOURNAL OF NEUROSCIENCE

Peripheral thermosensation in mammals

(2014) Joris Vriens et al.   NATURE REVIEWS NEUROSCIENCE

A vascular mechanistic approach to understanding Raynaud phenomenon

(2014) Nicholas A. Flavahan   Nature Reviews Rheumatology

TRPA1 is essential for the vascular response to environmental cold exposure

(2014) Aisah A. Aubdool et al.   Nature Communications

Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation

(2014) Cruz Morenilla-Palao et al.   Cell Reports

Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis

(2014) Domenico Tupone et al.   Frontiers in Neuroscience

Enhanced insulin clearance in mice lacking TRPM8 channels

(2013) Daniel D. McCoy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition

(2013) Viktor V. Feketa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The anti-diabetic drug glibenclamide is an agonist of the transient receptor potential Ankyrin 1 (TRPA1) ion channel

(2013) Alexandru Babes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Cellular Code for Mammalian Thermosensation

(2013) L. A. Pogorzala et al.   JOURNAL OF NEUROSCIENCE

A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia

(2013) W. M. Knowlton et al.   JOURNAL OF NEUROSCIENCE

Intragastric Administration of Allyl Isothiocyanate Reduces Hyperglycemia in Intraperitoneal Glucose Tolerance Test (IPGTT) by Enhancing Blood Glucose Consumption in Mice

(2013) Noriyuki MORI et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production

(2013) Marco Rossato et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

TRPM8 activation attenuates inflammatory responses in mouse models of colitis

(2013) R. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fat cells directly sense temperature to activate thermogenesis

(2013) L. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular and Cellular Basis of Cold Sensation

(2012) David D. McKemy   ACS Chemical Neuroscience

Nighttime snacking reduces whole body fat oxidation and increases LDL cholesterol in healthy young women

(2012) Masanobu Hibi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

TRPA1: A Gatekeeper for Inflammation

(2012) Diana M. Bautista et al.   Annual Review of Physiology

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

(2012) Li Ye et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature

(2012) M. C. Almeida et al.   JOURNAL OF NEUROSCIENCE

Ingestion of Cinnamaldehyde, a TRPA1 Agonist, Reduces Visceral Fats in Mice Fed a High-Fat and High-Sucrose Diet

(2012) Yasuko TAMURA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Transient Receptor Potential Melastatin 8 (TRPM8) Channels are Involved in Body Temperature Regulation

(2012) Narender R Gavva et al.   Molecular Pain

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice

(2012) Sharon Lim et al.   Nature Protocols

Core temperature: a forgotten variable in energy expenditure and obesity?

(2012) L. Landsberg   Obesity Reviews

Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity

(2012) Shuangtao Ma et al.   Journal of Molecular Cell Biology

The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

(2011) Lishi Li et al.   CELL

The Capsaicin Receptor TRPV1 Is a Crucial Mediator of the Noxious Effects of Mustard Oil

(2011) Wouter Everaerts et al.   CURRENT BIOLOGY

Transient Receptor Potential Ankyrin 1 Is Expressed by Inhibitory Motoneurons of the Mouse Intestine

(2011) Daniel P. Poole et al.   GASTROENTEROLOGY

Thermoregulatory Phenotype of the Trpv1 Knockout Mouse: Thermoeffector Dysbalance with Hyperkinesis

(2011) A. Garami et al.   JOURNAL OF NEUROSCIENCE

Central efferent pathways for cold-defensive and febrile shivering

(2011) Kazuhiro Nakamura et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation

(2011) Romina Nassini et al.   PAIN

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

(2011) Jun Chen et al.   PAIN

Cooling-Sensitive TRPM8 Is Thermostat of Skin Temperature against Cooling

(2011) Koji Tajino et al.   PLoS One

Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice

(2011) Wendy M. Knowlton et al.   PLoS One

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

(2011) K. Zimmermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV1-lineage neurons are required for thermal sensation

(2010) Santosh K Mishra et al.   EMBO JOURNAL

Central neural pathways for thermoregulation

(2010) Shaun et al.   Frontiers in Bioscience-Landmark

Nonshivering thermogenesis and its adequate measurement in metabolic studies

(2010) B. Cannon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea

(2010) Andrés Parra et al.   NATURE MEDICINE

Brown adipose tissue—a new role in humans?

(2010) Martin E. Lidell et al.   Nature Reviews Endocrinology

Higher 24-h Respiratory Quotient and Higher Spontaneous Physical Activity in Nighttime Eaters

(2010) Marci E. Gluck et al.   Obesity

TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo

(2010) Wendy M. Knowlton et al.   PAIN

Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone

(2009) Christopher D. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mechanisms of action, physiological effects, and complications of hypothermia

(2009) Kees H. Polderman   CRITICAL CARE MEDICINE

Energy metabolism, fuel selection and body weight regulation

(2009) J Galgani et al.   INTERNATIONAL JOURNAL OF OBESITY

Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation

(2009) Kelvin Y. Kwan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a Balance between TRPM8 and Kv1 Potassium Channels

(2009) R. Madrid et al.   JOURNAL OF NEUROSCIENCE

Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors

(2009) Rebecca P. Seal et al.   NATURE

TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells

(2009) K. Nozawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPA1 acts as a cold sensor in vitro and in vivo

(2009) Y. Karashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermogenesis challenges the adipostat hypothesis for body-weight control

(2009) Barbara Cannon et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Converting cold into pain

(2009) Carlos Belmonte et al.   EXPERIMENTAL BRAIN RESEARCH

Central control of thermogenesis in mammals

(2008) Shaun F. Morrison et al.   EXPERIMENTAL PHYSIOLOGY

Visualizing Cold Spots: TRPM8-Expressing Sensory Neurons and Their Projections

(2008) A. Dhaka et al.   JOURNAL OF NEUROSCIENCE

TRPA1 Channels Mediate Cold Temperature Sensing in Mammalian Vagal Sensory Neurons: Pharmacological and Genetic Evidence

(2008) O. Fajardo et al.   JOURNAL OF NEUROSCIENCE

Neuronal TRP channels: thermometers, pathfinders and life-savers

(2008) Karel Talavera et al.   TRENDS IN NEUROSCIENCES

Acetaminophen: Antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant

(2007) Shuxin Li et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS