Inhibition of TRPA1 Attenuates Doxorubicin-Induced Acute Cardiotoxicity by Suppressing Oxidative Stress, the Inflammatory Response, and Endoplasmic Reticulum Stress

Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca 2+ overload in rat cardiomyocytes

(2017) Rong-chang Chen et al.   TOXICOLOGY LETTERS

Transient Receptor Potential Ankyrin 1 Channels Modulate Inflammatory Response in Respiratory Cells from Patients with Cystic Fibrosis

(2016) Paola Prandini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia–reperfusion Injury in Rodents

(2016) Yao Lu et al.   ANESTHESIOLOGY

TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress

(2016) Gabriela Trevisan et al.   BRAIN

TRPA1 is functionally co-expressed with TRPV1 in cardiac muscle: Co-localization at z-discs, costameres and intercalated discs

(2016) Spencer R. Andrei et al.   Channels

Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-Induced Cardiac DysfunctionNovelty and Significance

(2016) Hai Ying Fu et al.   CIRCULATION RESEARCH

Docosahexaenoic Acid Attenuates Doxorubicin-induced Cytotoxicity and Inflammation by Suppressing NF-κB/iNOS/NO Signaling Pathway Activation in H9C2 Cardiac Cells

(2016) Zhi-Quan Wang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cardiotoxicity of anticancer therapy

(2016) Irene Fernández-Ruiz   Nature Reviews Cardiology

Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity

(2016) Michela Pecoraro et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity

(2016) Motoi Kobayashi et al.   Scientific Reports

Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein

(2016) Lei Wang et al.   Scientific Reports

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

d-limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats

(2014) Muneeb U Rehman et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout

(2014) Gabriela Trevisan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prevention of Anthracycline-Induced Cardiotoxicity

(2014) Pimprapa Vejpongsa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

TRPA1 is required for TGF-β signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma

(2014) Yuka Okada et al.   LABORATORY INVESTIGATION

TRPA1: A Gatekeeper for Inflammation

(2012) Diana M. Bautista et al.   Annual Review of Physiology

Free radicals and antioxidants: updating a personal view

(2012) Barry Halliwell   NUTRITION REVIEWS

The transient receptor potential channel TRPA1: from gene to pathophysiology

(2012) Bernd Nilius et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Early Detection and Prediction of Cardiotoxicity in Chemotherapy-Treated Patients

(2011) Heloisa Sawaya et al.   AMERICAN JOURNAL OF CARDIOLOGY

Catechin protects against oxidative stress and inflammatory-mediated cardiotoxicity in adriamycin-treated rats

(2011) Tarek A. Abd El-Aziz et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

TRPA1 underlies a sensing mechanism for O2

(2011) Nobuaki Takahashi et al.   Nature Chemical Biology

TRP Channels as Sensors and Signal Integrators of Redox Status Changes

(2011) Nobuaki Takahashi et al.   Frontiers in Pharmacology

Transient receptor potential ankyrin 1: emerging pharmacology and indications for cardiovascular biology

(2010) J. V. Bodkin et al.   Acta Physiologica

Nox2 NADPH Oxidase Promotes Pathologic Cardiac Remodeling Associated with Doxorubicin Chemotherapy

(2010) Y. Zhao et al.   CANCER RESEARCH

Ablation of C/EBP Homologous Protein Attenuates Endoplasmic Reticulum–Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload

(2010) Hai Ying Fu et al.   CIRCULATION

Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease

(2010) Tetsuo Minamino et al.   CIRCULATION RESEARCH

ER stress in cardiovascular disease

(2009) Tetsuo Minamino et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Over-expression of a modified bifunctional apoptosis regulator protects against cardiac injury and doxorubicin-induced cardiotoxicity in transgenic mice

(2008) C. C. Chua et al.   CARDIOVASCULAR RESEARCH

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE