Article
Biochemistry & Molecular Biology
Ines Drenjancevic, Jan Pitha
Summary: In addition to proven medications, omega-3 polyunsaturated fatty acids (n-3 PUFAs) are considered to have additive effects on cardiovascular health. They influence the cardiovascular system through various mechanisms, including effects on metabolism, inflammation, thrombosis, and direct effects on cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Lorena Ortega, Lorena Lobos-Gonzalez, Mauricio Reyna-Jeldes, Daniela Cerda, Erwin De la Fuente-Ortega, Patricio Castro, Giuliano Bernal, Claudio Coddou
Summary: This study demonstrated that docosahexaenoic acid (DHA) has a selective antiproliferative effect on gastric cancer (GC), primarily driven by apoptosis induction. DHA treatment consistently reduced tumor size, ascitic fluid volume, and liver metastasis in an in vivo mouse model. These findings provide promising potential for DHA as a therapeutic agent in GC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Review
Nutrition & Dietetics
Matheus H. Theinel, Mariana P. Nucci, Arielly H. Alves, Olivia F. M. Dias, Javier B. Mamani, Murilo M. Garrigos, Fernando A. Oliveira, Gabriel N. A. Rego, Nicole M. E. Valle, Gabriela Cianciarullo, Lionel F. Gamarra
Summary: A systematic review was conducted to study the effects of omega-3 polyunsaturated fatty acid (PUFA) supplements on breast cancer prevention and treatment. Out of 679 articles, only 27 were included and examined based on various factors such as induction type, experimental design, fatty acid composition, and analysis of outcomes. The findings suggest that omega-3 PUFA supplementation, particularly in combination with antitumor drugs, can have positive effects on tumor growth and metastases. However, the effectiveness of omega-3 PUFA supplementation without antitumor agents remains uncertain.
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Article
Hematology
Adriana Yamaguchi, Livia Stanger, Cody J. Freedman, Melissa Standley, Timothy Hoang, Reheman Adili, Wan-Chen Tsai, Christopher van Hoorebeke, Theodore R. Holman, Michael Holinstat
Summary: DHA and its 12-LOX oxylipins, 11-HDHA and 14-HDHA, attenuate platelet aggregation, inhibit IIb β3 activation, decrease α-granule secretion, impair platelet adhesion and accumulation, and inhibit thrombus formation. The protective mechanism of DHA oxylipins is mediated via activation of protein kinase A, supporting their use as therapeutic intervention in atherothrombotic diseases.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Environmental Sciences
Shuangfei Li, Boyu Wang, Liangxu Liu, Yingjie Song, Chuhan Lv, Xingyu Zhu, Yanqing Luo, Christopher H. K. Cheng, Huapu Chen, Xuewei Yang, Tao Li
Summary: The study demonstrates that adding Aurantiochytrium sp. to diets can significantly improve the growth performance and immune response of Trachinotus ovatus. With increased microalgae content, the growth rate and feed utilization efficiency of fish were enhanced, along with increased fatty acid content in blood and tissues, resulting in improved immunity and disease resistance in fish.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Nutrition & Dietetics
Masayuki Okuda, Aya Fujiwara, Satoshi Sasaki
Summary: The study found that in Japanese youths, high intake of omega-6 polyunsaturated fatty acids was associated with low levels of low-density-lipoprotein cholesterol, while high intake of saturated fatty acids was associated with high levels of gamma-glutamyl transpeptidase, indicating a close relationship between dietary fatty acid composition and cardiometabolic risk.
Article
Anatomy & Morphology
Hassan Reda Hassan Elsayed, Hanan S. Anbar, Mohammed R. Rabei, Mohamed Adel, Randa El-Gamal
Summary: The study found that Omega-3 fatty acids could decrease MTX-induced splenic injury, reduce oxidative stress markers, improve anti-apoptotic and anti-inflammatory conditions, and increase immune cell levels. Therefore, Omega-3 may be a promising adjuvant therapy for MTX, helping prevent its deleterious effects on the spleen.
Article
Biochemistry & Molecular Biology
Jiaxin Feng, Qianwen Wang, Wei Yang, Jun Liu, Ming-Qing Gao
Summary: Ω-3 PUFAs have a positive effect on LPS-induced inflammatory response, possibly mediated by the NF-kappa B signaling pathway and the intestinal microbiota.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Nutrition & Dietetics
Lingsi Zeng, Honggang Lv, Xubo Wang, Ranran Xue, Cong Zhou, Xia Liu, Hao Yu
Summary: Using Mendelian randomization (MR) analysis, this study found potential causal relationships between levels of fatty acids (FA) and the risk of depression. Specifically, oleic acid (OA) and alpha-linolenic acid (ALA) were identified as potential risk factors for depression, while adrenic acid and eicosapentaenoic acid (EPA) were found to be protective. These findings emphasize the importance of further research to investigate the underlying mechanisms that mediate the association between these fatty acids and depression risk.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Sarah Fathima, Ekatherine Prokopiou, Tassos Georgiou
Summary: Diabetic retinopathy is a common complication of type 2 Diabetes Mellitus that can lead to vision loss. The use of anti-oxidants for treatment has not been strongly supported by data. Omega-3 fatty acids have shown promising effects on cardiovascular health and their anti-oxidative and anti-inflammatory properties make them potential therapeutic agents for diabetic retinopathy. However, more clinical trials are needed to fully understand their benefits.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Agriculture, Dairy & Animal Science
Anna Wyrostek, Katarzyna Czyz, Ewa Sokola-Wysoczanska, Bozena Patkowska-Sokola, Wieslaw Bielas
Summary: This study examined the effect of supplementation with ethyl esters of linseed oil on the fatty acid profile in blood serum, erythrocyte membranes, and hair sebum of healthy beagle dogs. The results showed that the supplementation decreased the content of saturated fatty acids and increased the level of beneficial unsaturated fatty acids, especially those from the omega-3 family.
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Editorial Material
Food Science & Technology
Emanuele Rinninella, Lara Costantini
Summary: The International Scientific Association for Probiotics and Prebiotics (ISAPP) considers polyunsaturated fatty acids (PUFAs) as candidate prebiotics, although there is a lack of complete scientific evidence. Recent partial evidence shows that metabolites of PUFAs can have important health effects in the host, supporting the concept of the prebiotic action of PUFAs.