SIRT3: A New Regulator of Cardiovascular Diseases

AMPK attenuates ventricular remodeling and dysfunction following aortic banding in mice via the Sirt3/Oxidative stress pathway

(2017) Yili Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction

(2017) Masaki Kobayashi et al.   FEBS LETTERS

A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase

(2017) Jiaqi Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

EphB2 signaling-mediated Sirt3 expression reduces MSC senescence by maintaining mitochondrial ROS homeostasis

(2017) Young Hyun Jung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart

(2017) Shraddha S. Vadvalkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling

(2017) Mingming Zhang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Mohsen Naghavi et al.   LANCET

Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study

(2017) Mahshid Dehghan et al.   LANCET

SIRT3 inhibits Ang II-induced transdifferentiation of cardiac fibroblasts through β-catenin/PPAR-γ signaling

(2017) Xiaobin Guo et al.   LIFE SCIENCES

SIRT3 mediates decrease of oxidative damage and prevention of ageing in porcine fetal fibroblasts

(2017) Xiaoxian Xie et al.   LIFE SCIENCES

Green Tea Polyphenols Ameliorate the Early Renal Damage Induced by a High-Fat Diet via Ketogenesis/SIRT3 Pathway

(2017) Weijie Yi et al.   Oxidative Medicine and Cellular Longevity

Sirtuins Expression and Their Role in Retinal Diseases

(2017) Sankarathi Balaiya et al.   Oxidative Medicine and Cellular Longevity

Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals

(2017) Niria Treviño-Saldaña et al.   Oxidative Medicine and Cellular Longevity

Cardiac oxidative stress in diabetes: Mechanisms and therapeutic potential

(2017) Alyssa Faria et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondrial Sirtuins and Molecular Mechanisms of Aging

(2017) Robert A.H. van de Ven et al.   TRENDS IN MOLECULAR MEDICINE

MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila

(2017) Xiao Chen et al.   Nature Communications

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

(2017) Vinodkumar B. Pillai et al.   Oncotarget

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

(2017) Ming‐liang Chen et al.   Journal of the American Heart Association

Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis

(2017) Tong Wei et al.   Journal of the American Heart Association

High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities

(2017) Rebecca M. Parodi-Rullán et al.   Frontiers in Pharmacology

Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling

(2017) Liming Yu et al.   Scientific Reports

Receptor-interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes

(2016) J. You et al.   Acta Physiologica

Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice

(2016) Vinodkumar B. Pillai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3

(2016) Yang Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Preserved recovery of cardiac function following ischemia–reperfusion in mice lacking SIRT3

(2016) Christoph Koentges et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization

(2016) Wen Yang et al.   CELL

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

(2016) Aiwu Cheng et al.   Cell Metabolism

Using mitochondrial sirtuins as drug targets: disease implications and available compounds

(2016) Melanie Gertz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SIRT3-AMPK Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)

(2016) Yen-Chun Lai et al.   CIRCULATION

2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines

(2016) Jose Luis Zamorano et al.   EUROPEAN JOURNAL OF HEART FAILURE

NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy

(2016) Zhongbao Yue et al.   EXPERIMENTAL CELL RESEARCH

The glucagon like peptide 1 analogue, exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting Sirt1 and Sirt3 expression

(2016) Ying Zeng et al.   EXPERIMENTAL EYE RESEARCH

The role of mitochondrial sirtuins in health and disease

(2016) Brenna Osborne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial sirtuins in the heart

(2016) Heiko Bugger et al.   HEART FAILURE REVIEWS

Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia

(2016) Xiaochen He et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications

(2016) Yi Lu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway

(2016) YUE GUAN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1

(2016) Jianqiang Hu et al.   JOURNAL OF PINEAL RESEARCH

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Mohammad H Forouzanfar et al.   LANCET

Garlic activates SIRT-3 to prevent cardiac oxidative stress and mitochondrial dysfunction in diabetes

(2016) Md Razia Sultana et al.   LIFE SCIENCES

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation

(2016) Chong Zhao et al.   Oxidative Medicine and Cellular Longevity

PGC-1 alpha regulates HO-1 expression, mitochondrial dynamics and biogenesis: Role of epoxyeicosatrienoic acid

(2016) Shailendra P. Singh et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

A sirtuin activator and an anti-inflammatory molecule—multifaceted roles of adjudin and its potential applications for aging-related diseases

(2016) Weiliang Xia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro

(2016) Xiaoping Ji et al.   Drug Design Development and Therapy

Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1α

(2016) Nan Hu et al.   Oncotarget

NAMPT-Mediated NAD + Biosynthesis Is Essential for Vision In Mice

(2016) Jonathan B. Lin et al.   Cell Reports

Sirtuins Link Inflammation and Metabolism

(2016) Vidula T. Vachharajani et al.   Journal of Immunology Research

PLGA-PNIPAM Microspheres Loaded with the Gastrointestinal Nutrient NaB Ameliorate Cardiac Dysfunction by Activating Sirt3 in Acute Myocardial Infarction

(2016) Panke Cheng et al.   Advanced Science

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

Activation of SIRT3 by resveratrol ameliorates cardiac fibrosis and improves cardiac function via the TGF-β/Smad3 pathway

(2015) Tongshuai Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SIRT3 deficiency impairs mitochondrial and contractile function in the heart

(2015) Christoph Koentges et al.   BASIC RESEARCH IN CARDIOLOGY

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

(2015) Beshay N.M. Zordoky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes

(2015) Kyle G. Cheung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss

(2015) Heng Zeng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D

(2015) T. Bochaton et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Losartan Protects the Heart Against Ischemia Reperfusion Injury: Sirtuin3 Involvement

(2015) Mohsen Sharifi Klishadi et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Physical exercise prior and during treatment reduces sub-chronic doxorubicin-induced mitochondrial toxicity and oxidative stress

(2015) Inês Marques-Aleixo et al.   MITOCHONDRION

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

(2015) Nagalingam R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

Acetylation site specificities of lysine deacetylase inhibitors in human cells

(2015) Christian Schölz et al.   NATURE BIOTECHNOLOGY

Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway

(2015) F. Yang et al.   NEUROSCIENCE

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Mouse SIRT3 Attenuates Hypertrophy-Related Lipid Accumulation in the Heart through the Deacetylation of LCAD

(2015) Tongshuai Chen et al.   PLoS One

SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts

(2014) George A. Porter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling

(2014) Osama Abo Alrob et al.   CARDIOVASCULAR RESEARCH

Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans

(2014) Roxane Paulin et al.   Cell Metabolism

Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss

(2014) Kevin D. Brown et al.   Cell Metabolism

Regulation of Akt Signaling by Sirtuins

(2014) Vinodkumar B. Pillai et al.   CIRCULATION RESEARCH

Aerobic interval training protects against myocardial infarction-induced oxidative injury by enhancing antioxidase system and mitochondrial biosynthesis

(2014) Hong-Ke Jiang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes

(2014) Xuwei Hou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cardioprotective effects of rhamnetin in H9c2 cardiomyoblast cells under H2O2-induced apoptosis

(2014) Eun-Seok Park et al.   JOURNAL OF ETHNOPHARMACOLOGY

Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: Regulation by a polyphenol -(−)-epigallocatechin-3-gallate

(2014) Jia Liu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cardiovascular Risk and Events in 17 Low-, Middle-, and High-Income Countries

(2014) Salim Yusuf et al.   NEW ENGLAND JOURNAL OF MEDICINE

NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents

(2014) W. T. Harkcom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure

(2014) R C Poulsen et al.   Cell Death & Disease

Sirtuin 3 Deficiency Does Not Augment Hypoxia-Induced Pulmonary Hypertension

(2013) Gregory B. Waypa et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development

(2013) Stephan Winnik et al.   BASIC RESEARCH IN CARDIOLOGY

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

Direct Renin Inhibition Exerts an Anti-hypertrophic Effect Associated with Improved Mitochondrial Function in Post-infarction Heart Failure in Diabetic Rats

(2013) Rebecca Parodi-Rullan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

(2013) Sadhana A. Samant et al.   MOLECULAR AND CELLULAR BIOLOGY

Myocardial Injection of Apelin-Overexpressing Bone Marrow Cells Improves Cardiac Repair via Upregulation of Sirt3 after Myocardial Infarction

(2013) Lanfang Li et al.   PLoS One

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

(2013) L Wei et al.   Cell Death & Disease

Dietary Fat and Heart Failure: Moving From Lipotoxicity to Lipoprotection

(2012) William C. Stanley et al.   CIRCULATION RESEARCH

Exploring the therapeutic space around NAD+

(2012) Riekelt H. Houtkooper et al.   JOURNAL OF CELL BIOLOGY

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Non-histone lysine acetylated proteins in heart failure

(2011) Jean Michel Grillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Fine Tuning Our Cellular Factories: Sirtuins in Mitochondrial Biology

(2011) Lei Zhong et al.   Cell Metabolism

Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of theSirt3Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype

(2011) Albert Giralt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

(2011) Andrey Nikiforov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

(2011) William C. Hallows et al.   MOLECULAR CELL

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

(2011) Lydia W. S. Finley et al.   PLoS One

Association of the Sirtuin and Mitochondrial Uncoupling Protein Genes with Carotid Plaque

(2011) Chuanhui Dong et al.   PLoS One

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

There is More to Life than Revascularization: Therapeutic Targeting of Myocardial Ischemia/Reperfusion Injury

(2010) Robert M. Bell et al.   Cardiovascular Therapeutics

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

(2010) Tadahiro Shimazu et al.   Cell Metabolism

SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity

(2010) Jianjun Bao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms

(2010) Jianjun Bao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian Mitochondria

(2009) Huseyin Cimen et al.   BIOCHEMISTRY

NAD+-dependent Deacetylase SIRT3 Regulates Mitochondrial Protein Synthesis by Deacetylation of the Ribosomal Protein MRPL10

(2009) Yongjie Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

(2009) Nagalingam R. Sundaresan et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of the Ang II type 1 receptor promotes longevity in mice

(2009) Ariela Benigni et al.   JOURNAL OF CLINICAL INVESTIGATION

The human SIRT3 protein deacetylase is exclusively mitochondrial

(2008) Helen M. Cooper et al.   BIOCHEMICAL JOURNAL

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA