Article
Medicine, Research & Experimental
Lea Loisay, Davide Komla-Ebri, Anne Morice, Yann Heuze, Camille Viaut, Amelie de La Seigliere, Nabil Kaci, Danny Chan, Audrey Lamouroux, Genevieve Baujat, J. H. Duncan Bassett, Graham R. Williams, Laurence Legeai-Mallet
Summary: This study reports the generation of a new mouse model (Fgfr3Asn534Lys/+) that simulates the characteristics of HCH. The research also reveals the crucial role of FGFR3 in bone structure, highlighting the detrimental effect of the mutation on bone modeling during both developmental and aging processes.
Article
Biochemistry & Molecular Biology
Angela Fernandez-Iglesias, Rocio Fuente, Helena Gil-Pena, Laura Alonso-Duran, Fernando Santos, Jose Manuel Lopez
Summary: The study investigated the formation of the epiphyseal bone plate using various microscopy techniques and found that the bone tissue is generated through a process different from the usual endochondral ossification. Osteoblasts deposit bone matrix on various surfaces, leading to the establishment of a core of bone sheet and subsequent thickening and reshaping. The processes occur in close relationship with cartilage, providing insight into the complex cellular events underlying bone formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Orthopedics
Christian R. D'Andrea, Ausilah Alfraihat, Anita Singh, Jason B. Anari, Patrick J. Cahill, Thomas Schaer, Brian D. Snyder, Dawn Elliott, Sriram Balasubramanian
Summary: The review showed that macro-scale changes in longitudinal bone growth resulting from mechanical loading depend on load magnitude, anatomical location, and species. Variations in cyclic loading frequency and amplitude did not significantly affect longitudinal growth, but did impact the morphology, viability, and gene and protein expression within the growth plate. Intermittent compression regimens can preserve or increase growth plate height and stimulate chondrocyte presence in the hypertrophic zone.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
Marjolein M. J. Caron, Bert van Rietbergen, Tessy M. R. Castermans, Mirella J. J. Haartmans, Lodewijk W. van Rhijn, Tim J. M. Welting, Adhiambo M. A. Witlox
Summary: The study suggests that naproxen and MTX have an impact on endochondral ossification, leading to impaired skeletal development.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Cell & Tissue Engineering
Inho Baek, Alvin Bacero Bello, Jieun Jeon, Yoshie Arai, Byung-Hyun Cha, Byoung Ju Kim, Soo-Hong Lee
Summary: This study compared the characteristics of epiphyseal growth plate cells (EGPCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) and found that EGPCs showed better performance in chondrogenesis and osteogenesis. Additionally, EGPCs were able to promote the expression of bone and hypertrophic markers in BM-MSCs. In an osteoporosis model, EGPCs also demonstrated superior bone regeneration.
JOURNAL OF TISSUE ENGINEERING
(2022)
Review
Orthopedics
Christian R. D'Andrea, Ausilah Alfraihat, Anita Singh, Jason B. Anari, Patrick J. Cahill, Thomas Schaer, Brian D. Snyder, Dawn Elliott, Sriram Balasubramanian
Summary: This paper discusses the effects of mechanical loading on macro-scale bone growth alterations and factors affecting growth plate material properties. Findings indicate that growth plate morphology and viability are influenced by loading parameters.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Etienne Dardenne, Noboru Ishiyama, Tai -An Lin, Matthew C. Lucas
Summary: This article presents the mechanism of action, benefit, and potential mechanistic limitation of drugs currently being evaluated in clinical trials for achondroplasia, a rare disease affecting bone growth. It also discusses the potential impact of these drugs in increasing the growth of individuals with achondroplasia and improving their quality of life.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Mari Satoh, Yukihiro Hasegawa
Summary: Bone age is an important marker of bone maturation, influenced by various hormones including estrogens. Females generally have more advanced bone maturation than males. This study reviews the factors affecting bone age progression, as well as bone maturation and deformities in certain medical conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Kishor K. Sivaraj, Paul-Georg Majev, Hyun-Woo Jeong, Backialakshmi Dharmalingam, Dagmar Zeuschner, Silke Schroder, M. Gabriele Bixel, Melanie Timmen, Richard Stange, Ralf H. Adams
Summary: The study demonstrates the crucial role of mesenchymal stromal cell-derived septoclasts in development and fracture healing, showing their disappearance after development completion and re-emergence during fracture healing. These septoclasts disappear in adult and ageing bones but reappear in association with growing vessels during fracture healing.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wangyuan Yao, Muhammad Fakhar-e-Alam Kulyar, Yanmei Ding, Haitao Du, Jiajia Hong, Kyein San Loon, Shah Nawaz, Jiakui Li
Summary: The interaction between miR-140 and HDAC4 plays a crucial role in bone disorders such as tibial dyschondroplasia. Low miR-140 expression is associated with poor pathological characteristics and low chondrocyte survival. HDAC4 inhibits MEF2C and Runx2 and interacts with Col-II, Col-X, and COMP, leading to uncontrolled chondrocyte proliferation, differentiation, and dysplastic growth. Targeting the miR-140 and HDAC4 feedback loop may provide a promising therapeutic approach for chondrocyte-related bone disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Sho Tsukamoto, Mai Kuratani, Shinya Tanaka, Eijiro Jimi, Hiromi Oda, Takenobu Katagiri
Summary: Endochondral ossification is important for longitudinal skeletal growth. Osteoblasts, near hypertrophic chondrocytes, contribute to bone formation during this process. Smad4 knockout mice showed increased bone volume due to enhanced osteoblast-mediated bone formation via the Wnt7b-ft-catenin axis. Wnt7b, expressed in differentiated chondrocytes, was suppressed by BMP4 stimulation. Deletion of Wnt7b reduced bone increase in Smad4 knockout mice and inhibited skeletal growth in juveniles, highlighting its role in initiating endochondral ossification.
Article
Cell Biology
Marta Marchini, Mitchell R. Ashkin, Melina Bellini, Margaret Man-Ger Sun, Matthew Lloyd Workentine, Hamza Malik Okuyan, Roman Krawetz, Frank Beier, Campbell Rolian
Summary: The genetic and developmental mechanisms of limb formation are well understood, but how chondrocyte physiology modulates these mechanisms to produce differences in limb bone length is unclear. Through RNA sequencing and cell culture experiments, it was found that NKA plays a key role in chondrocyte differentiation and regulation of bone length, with implications for limb length diversity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ming Liang Chan, Yulan Qi, Kevin Larimore, Anu Cherukuri, Lori Seid, Kala Jayaram, George Jeha, Elena Fisheleva, Jonathan Day, Alice Huntsman-Labed, Ravi Savarirayan, Melita Irving, Carlos A. Bacino, Julie Hoover-Fong, Keiichi Ozono, Klaus Mohnike, William R. Wilcox, William A. Horton, Joshua Henshaw
Summary: The results suggest that vosoritide at a dose of 15 µg/kg for once-daily subcutaneous administration is effective in children with achondroplasia aged 5 years and older whose epiphyses are not closed. Exposure-response relationships were observed for changes in growth velocity and biomarkers, with systemic pharmacological activity being near maximal at the highest dose studied. No meaningful correlations were found between vosoritide plasma exposure and changes in growth velocity or biomarkers in the phase III study.
CLINICAL PHARMACOKINETICS
(2022)
Article
Clinical Neurology
Hiroaki Manabe, Kazuta Yamashita, Kosaku Higashino, Masatoshi Morimoto, Kosuke Sugiura, Yoshihiro Ishihama, Fumitake Tezuka, Yoichiro Takata, Toshinori Sakai, Koichi Sairyo
Summary: This study used rat spondylolisthesis models to investigate the mechanism for correction of vertebral rounding deformity, and found that tail suspension could improve this deformity possibly through enhancing chondrocyte differentiation.
Article
Cell Biology
Xijuan Liu, Jian Zhang, Jinghong Yuan, Rui Ding, Tao Liu, Jingyu Jia
Summary: This study aimed to identify differential plasma protein expression and novel biomarkers in patients with idiopathic short stature (ISS) and investigate the biological functions of candidate proteins in ISS pathogenesis. The study found that LCN2 may be a significant target for ISS diagnosis and treatment.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)