Controlling the master—upstream regulation of the tumor suppressor LKB1

LKB1 Controls the Pluripotent State of Human Embryonic Stem Cells

(2018) Dongmei Lai et al.   Cellular Reprogramming

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation

(2017) Fergal O’Farrell et al.   NATURE CELL BIOLOGY

Aurora-A-mediated phosphorylation of LKB1 compromises LKB1/AMPK signaling axis to facilitate NSCLC growth and migration

(2017) X Zheng et al.   ONCOGENE

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

(2017) S Sengupta et al.   ONCOGENE

Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression

(2017) Giada Dogliotti et al.   Nature Communications

LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion

(2016) Jessica Konen et al.   MOLECULAR BIOLOGY OF THE CELL

Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report

(2016) Natascha Cidlinsky et al.   CELLULAR ONCOLOGY

The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1–p70S6K–RPS6 signaling

(2015) Timothy D. Calamaras et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipopolysaccharides PromoteS-Nitrosylation and Proteasomal Degradation of Liver Kinase B1 (LKB1) in Macrophagesin Vivo

(2015) Zhaoyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress

(2015) Szu-Wei Lee et al.   MOLECULAR CELL

Loss of LKB1 and p53 synergizes to alter fallopian tube epithelial phenotype and high-grade serous tumorigenesis

(2015) S H L George et al.   ONCOGENE

Honokiol activates the LKB1–AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes

(2015) Min Suk Seo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

(2015) Lucía Barbier-Torres et al.   Oncotarget

A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress

(2015) Joan Ritho et al.   Cell Reports

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Endothelial Cell–Specific Liver Kinase B1 Deletion Causes Endothelial Dysfunction and Hypertension in Mice In Vivo

(2014) Wencheng Zhang et al.   CIRCULATION

Investigation of LKB1 Ser431phosphorylation and Cys433farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

(2013) Vanessa P. Houde et al.   BIOCHEMICAL JOURNAL

Evidence for tankyrases as antineoplastic targets in lung cancer

(2013) Alexander M Busch et al.   BMC CANCER

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

Identification of molecular alterations in gastrointestinal carcinomas and dysplastic hamartomas in Peutz-Jeghers syndrome

(2013) Susanne E. Korsse et al.   CARCINOGENESIS

Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer

(2013) Pradeep S. Tanwar et al.   CARCINOGENESIS

Terminal Axon Branching Is Regulated by the LKB1-NUAK1 Kinase Pathway via Presynaptic Mitochondrial Capture

(2013) Julien Courchet et al.   CELL

AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation

(2013) Ya-Lin Zhang et al.   Cell Metabolism

Regulation and therapeutic strategies of 4-hydroxy-2-nonenal metabolism in heart disease

(2013) V. R. Mali et al.   FREE RADICAL RESEARCH

Phosphorylation of Serine 399 in LKB1 Protein Short Form by Protein Kinase Cζ Is Required for Its Nucleocytoplasmic Transport and Consequent AMP-activated Protein Kinase (AMPK) Activation

(2013) Huaiping Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt Signaling Pathway in Non-Small Cell Lung Cancer

(2013) D. J. Stewart   JNCI-Journal of the National Cancer Institute

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

14-3-3 Interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function

(2012) Yu Bai et al.   FEBS LETTERS

Post-translational Modification of Serine/Threonine Kinase LKB1 via Adduction of the Reactive Lipid Species 4-Hydroxy-trans-2-nonenal (HNE) at Lysine Residue 97 Directly Inhibits Kinase Activity

(2012) Timothy D. Calamaras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer

(2011) R K Gill et al.   ONCOGENE

Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1

(2011) H Gaude et al.   ONCOGENE

SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells

(2010) Yi Zu et al.   CIRCULATION RESEARCH

LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest

(2010) Jennifer P. Morton et al.   GASTROENTEROLOGY

Isoform-specific Regulation of Akt Signaling by the Endosomal Protein WDFY2

(2010) Helena A. Walz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

(2010) Sushma Gurumurthy et al.   NATURE

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

(2010) Boyi Gan et al.   NATURE

Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development

(2010) W-L Yang et al.   ONCOGENE

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LKB1 Regulates Pancreatic β Cell Size, Polarity, and Function

(2009) Zvi Granot et al.   Cell Metabolism

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

(2009) Vernon W. Dolinsky et al.   CIRCULATION

Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction

(2009) Yasumasa Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis

(2009) Z. Xie et al.   MOLECULAR AND CELLULAR BIOLOGY

Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation

(2009) Bin Zheng et al.   MOLECULAR CELL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Somatic LKB1 Mutations Promote Cervical Cancer Progression

(2009) Shana N. Wingo et al.   PLoS One

LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye

(2009) N. Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

(2008) Mhairi C. Towler et al.   BIOCHEMICAL JOURNAL

Phosphorylation of LKB1 at Serine 428 by Protein Kinase C-ζ Is Required for Metformin-Enhanced Activation of the AMP-Activated Protein Kinase in Endothelial Cells

(2008) Zhonglin Xie et al.   CIRCULATION

Regulation of LKB1/STRAD Localization and Function by E-Cadherin

(2008) Michael Sebbagh et al.   CURRENT BIOLOGY

Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes

(2008) Laurent Bultot et al.   FEBS LETTERS

Investigating the Regulation of Brain-specific Kinases 1 and 2 by Phosphorylation

(2008) Nicola J. Bright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of an Alternative Splice Variant of LKB1

(2008) Fiona C. Denison et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest

(2008) Sarah Fogarty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase Cζ-dependent LKB1 Serine 428 Phosphorylation Increases LKB1 Nucleus Export and Apoptosis in Endothelial Cells

(2008) Ping Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STRADα Regulates LKB1 Localization by Blocking Access to Importin-α, and by Association with Crm1 and Exportin-7

(2008) Julia Dorfman et al.   MOLECULAR BIOLOGY OF THE CELL