Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer

Perturbation of Rb, p53, and Brca1 or Brca2 Cooperate in Inducing Metastatic Serous Epithelial Ovarian Cancer

(2012) Ludmila Szabova et al.   CANCER RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis

(2012) Pradeep S. Tanwar et al.   HUMAN MOLECULAR GENETICS

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

(2012) Kathryn M. Kinross et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome Wide DNA Copy Number Analysis of Serous Type Ovarian Carcinomas Identifies Genetic Markers Predictive of Clinical Outcome

(2012) David A. Engler et al.   PLoS One

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity

(2012) J. I. Partanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-grade serous ovarian cancer arises from fallopian tube in a mouse model

(2012) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential

(2012) N. L. Solimini et al.   SCIENCE

Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1

(2012) Pradeep S. Tanwar et al.   PLoS Genetics

A Comprehensive Analysis of PAX8 Expression in Human Epithelial Tumors

(2011) Anna R. Laury et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Stromal Deletion of the APC Tumor Suppressor in Mice Triggers Development of Endometrial Cancer

(2011) P. S. Tanwar et al.   CANCER RESEARCH

Deletion of Tuberous Sclerosis 1 in Somatic Cells of the Murine Reproductive Tract Causes Female Infertility

(2011) Yoshihiro Tanaka et al.   ENDOCRINOLOGY

Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer

(2011) Jae Hong No et al.   GYNECOLOGIC ONCOLOGY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo

(2011) L K Mullany et al.   ONCOGENE

Lkb1 and Pten Synergise to Suppress mTOR-Mediated Tumorigenesis and Epithelial-Mesenchymal Transition in the Mouse Bladder

(2011) Boris Y. Shorning et al.   PLoS One

Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian Endometrioid Adenocarcinomas with Dysregulated Wnt/β-Catenin and PTEN

(2011) Pradeep S. Tanwar et al.   PLoS One

Activation of mTOR signaling pathway contributes to survival of cervical cancer cells

(2010) Jing Ji et al.   GYNECOLOGIC ONCOLOGY

Cell Type-Specific Targeted Mutations of Kras and Pten Document Proliferation Arrest in Granulosa Cells versus Oncogenic Insult to Ovarian Surface Epithelial Cells

(2009) H.-Y. Fan et al.   CANCER RESEARCH

Conditional Inactivation of Brca1, p53 and Rb in Mouse Ovaries Results in the Development of Leiomyosarcomas

(2009) Katherine V. Clark-Knowles et al.   PLoS One

Induction of Ovarian Leiomyosarcomas in Mice by Conditional Inactivation of Brca1 and p53

(2009) Bridget A. Quinn et al.   PLoS One

Ovarian Cancer Pathogenesis: A Model in Evolution

(2009) Alison M. Karst et al.   Journal of Oncology

Ovarian Cancer

(2008) Kathleen R. Cho et al.   Annual Review of Pathology-Mechanisms of Disease

Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

(2008) Xu Huang et al.   BIOCHEMICAL JOURNAL

Conditional Loss of Uterine Pten Unfailingly and Rapidly Induces Endometrial Cancer in Mice

(2008) T. Daikoku et al.   CANCER RESEARCH

LKB1; linking cell structure and tumor suppression

(2008) A F Hezel et al.   ONCOGENE