Evidence for tankyrases as antineoplastic targets in lung cancer

Wnt pathway contributes to the protection by bone marrow stromal cells of acute lymphoblastic leukemia cells and is a potential therapeutic target

(2013) Yang Yang et al.   CANCER LETTERS

Discovery of a Class of Novel Tankyrase Inhibitors that Bind to Both the Nicotinamide Pocket and the Induced Pocket

(2013) Howard Bregman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

(2012) Christina A. Kirby et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Advances in using PARP inhibitors to treat cancer

(2012) Shivaani Kummar et al.   BMC Medicine

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Abstract 1425: Prognostic significance of promoter DNA methylation in patients with neuroblastoma

(2012) Diana T. Lau et al.   CANCER RESEARCH

A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

(2012) J. Waaler et al.   CANCER RESEARCH

Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition

(2012) Matias Casás-Selves et al.   CANCER RESEARCH

Structural Basis of Selective Inhibition of Human Tankyrases

(2012) Mohit Narwal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Impact of Reduced Tobacco Smoking on Lung Cancer Mortality in the United States During 1975–2000

(2012) Suresh H. Moolgavkar et al.   JNCI-Journal of the National Cancer Institute

Evidence for the Ubiquitin Protease UBP43 as an Antineoplastic Target

(2012) Y. Guo et al.   MOLECULAR CANCER THERAPEUTICS

Deletion of Porcn in Mice Leads to Multiple Developmental Defects and Models Human Focal Dermal Hypoplasia (Goltz Syndrome)

(2012) Wei Liu et al.   PLoS One

Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells

(2012) Renyue Bao et al.   PLoS One

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Bexarotene Plus Erlotinib Suppress Lung Carcinogenesis Independent of KRAS Mutations in Two Clinical Trials and Transgenic Models

(2011) K. H. Dragnev et al.   Cancer Prevention Research

Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium

(2011) Eugenia C. Pacheco-Pinedo et al.   JOURNAL OF CLINICAL INVESTIGATION

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

(2011) Karen A Gelmon et al.   LANCET ONCOLOGY

Wnt3 gene expression promotes tumor progression in non-small cell lung cancer

(2011) Nariyasu Nakashima et al.   LUNG CANCER

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

(2011) Marinella G. Callow et al.   PLoS One

Cyclin E Transgenic Mice: Discovery Tools for Lung Cancer Biology, Therapy, and Prevention

(2010) S. J. Freemantle et al.   Cancer Prevention Research

Tankyrase is necessary for canonical Wnt signaling during kidney development

(2010) Courtney M. Karner et al.   DEVELOPMENTAL DYNAMICS

MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors

(2010) Xi Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Basis for the Interaction between Tankyrase-2 and a Potent Wnt-Signaling Inhibitor

(2010) Tobias Karlberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

(2010) Felipe C Geyer et al.   MODERN PATHOLOGY

Lentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway

(2010) Christophe Fuerer et al.   PLoS One

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Structure–activity relationship studies of small-molecule inhibitors of Wnt response

(2009) Jianming Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting

(2009) Grace E Snow et al.   BMC CANCER

The 6q22.33 Locus and Breast Cancer Susceptibility

(2009) T. Kirchhoff et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast Cancer

(2009) Theresa A. DiMeo et al.   CANCER RESEARCH

WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis

(2009) Don X. Nguyen et al.   CELL

Targeting the Cyclin E-Cdk-2 Complex Represses Lung Cancer Growth by Triggering Anaphase Catastrophe

(2009) F. Galimberti et al.   CLINICAL CANCER RESEARCH

Uncovering Growth-Suppressive MicroRNAs in Lung Cancer

(2009) X. Liu et al.   CLINICAL CANCER RESEARCH

The RNF146 and ECHDC1 genes as candidates for inherited breast and ovarian cancer in Jewish Ashkenazi women

(2009) Tal Distelman Menachem et al.   Familial Cancer

Interaction between Poly(ADP-ribose) and NuMA Contributes to Mitotic Spindle Pole Assembly

(2009) Paul Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma

(2009) G Akiri et al.   ONCOGENE

Plasma membrane recruitment of dephosphorylated  -catenin upon activation of the Wnt pathway

(2008) J. Hendriksen et al.   JOURNAL OF CELL SCIENCE

Tankyrase function at telomeres, spindle poles, and beyond

(2007) Susan J. Hsiao et al.   BIOCHIMIE