LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion

Pigment Epithelium-Derived Factor Blocks Tumor Extravasation by Suppressing Amoeboid Morphology and Mesenchymal Proteolysis

(2015) Omar Ladhani et al.   NEOPLASIA

Trading in your spindles for blebs: the amoeboid tumor cell phenotype in prostate cancer

(2014) Dolores Di Vizio et al.   ASIAN JOURNAL OF ANDROLOGY

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues

(2014) Keefe T. Chan et al.   JOURNAL OF CELL BIOLOGY

Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion

(2014) Juan Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential

(2014) Jonathan M. Goodwin et al.   MOLECULAR CELL

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma

(2014) Miwako Kakiuchi et al.   NATURE GENETICS

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

(2014) Kai Wang et al.   NATURE GENETICS

Vimentin regulates lung cancer cell adhesion through a VAV2–Rac1 pathway to control focal adhesion kinase activity

(2014) L S Havel et al.   ONCOGENE

Investigation of LKB1 Ser431phosphorylation and Cys433farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

(2013) Vanessa P. Houde et al.   BIOCHEMICAL JOURNAL

LKB1 and AMPK and the cancer-metabolism link - ten years after

(2013) D Hardie et al.   BMC BIOLOGY

Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling

(2013) Jan Kosla et al.   Cell Communication and Signaling

LKB1 Represses Focal Adhesion Kinase (FAK) Signaling via a FAK-LKB1 Complex to Regulate FAK Site Maturation and Directional Persistence

(2013) Erik R. Kline et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity

(2012) Xiaojian Xu et al.   BMC CELL BIOLOGY

LKB1 and AMP-activated protein kinase: regulators of cell polarity

(2012) Atsushi Nakano et al.   GENES TO CELLS

Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways

(2012) Bryan Lo et al.   JOURNAL OF CELL BIOLOGY

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity

(2012) J. I. Partanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers

(2011) T. Vallenius et al.   JOURNAL OF CELL SCIENCE

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

(2010) Julian Carretero et al.   CANCER CELL

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

LKB1 Regulated Pathways in Lung Cancer Invasion and Metastasis

(2010) Adam I. Marcus et al.   Journal of Thoracic Oncology

Involvement of LKB1 in epithelial–mesenchymal transition (EMT) of human lung cancer cells

(2010) Badal C. Roy et al.   LUNG CANCER

LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

(2010) Y. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

(2010) A. Zagorska et al.   Science Signaling

Somatic LKB1 Mutations Promote Cervical Cancer Progression

(2009) Shana N. Wingo et al.   PLoS One

LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye

(2009) N. Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tumor Suppressor LKB1 Regulates Lung Cancer Cell Polarity by Mediating cdc42 Recruitment and Activity

(2008) S. Zhang et al.   CANCER RESEARCH

Up-Regulation of Rho/ROCK Signaling in Sarcoma Cells Drives Invasion and Increased Generation of Protrusive Forces

(2008) D. Rosel et al.   MOLECULAR CANCER RESEARCH

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

LKB1; linking cell structure and tumor suppression

(2008) A F Hezel et al.   ONCOGENE