Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations

Protein amino-terminal modifications and proteomic approaches for N-terminal profiling

(2015) Zon W Lai et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance

(2015) C. Duluc et al.   EMBO Molecular Medicine

Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells

(2015) Ursula Kern et al.   Molecular Cancer

Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma

(2015) DIMITRIOS PATSOURAS et al.   Molecular Medicine Reports

Fibroblast activation protein α in tumor microenvironment: Recent progression and implications (Review)

(2015) FUMING ZI et al.   Molecular Medicine Reports

Versatile functions for IL-6 in metabolism and cancer

(2015) Jan Mauer et al.   TRENDS IN IMMUNOLOGY

Molecular mechanism underlying the tumor-promoting functions of carcinoma-associated fibroblasts

(2015) Yali Han et al.   TUMOR BIOLOGY

Aurora B expression and histone variant H1.4S27 phosphorylation are no longer coordinated during metaphase in aneuploid colorectal carcinomas

(2015) Fahima Sijare et al.   VIRCHOWS ARCHIV

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

A new angle on blood-CNS interfaces: A role for connexins?

(2014) Marijke De Bock et al.   FEBS LETTERS

Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)

(2014) Koen Jansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Upregulated expression and activation of membrane-associated proteases in esophageal squamous cell carcinoma

(2014) KATARZYNA AUGOFF et al.   ONCOLOGY REPORTS

Increased Expression of CCN2, Epithelial Membrane Antigen, and Fibroblast Activation Protein in Hepatocellular Carcinoma with Fibrous Stroma Showing Aggressive Behavior

(2014) Gi Jeong Kim et al.   PLoS One

RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation

(2014) Woosook Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteases and Disease

(2014)   Proteomics Clinical Applications

Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy

(2014) Elizabeth J. Hamson et al.   Proteomics Clinical Applications

Network Analyses Reveal Pervasive Functional Regulation Between Proteases in the Human Protease Web

(2014) Nikolaus Fortelny et al.   PLOS BIOLOGY

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

Over-expression of fibroblast activation protein alpha increases tumor growth in xenografts of ovarian cancer cells

(2013) L. Yang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Microenvironment and tumor cell plasticity: An easy way out

(2013) Maria Letizia Taddei et al.   CANCER LETTERS

The stromal compartments in pancreatic cancer: Are there any therapeutic targets?

(2013) Serena Lunardi et al.   CANCER LETTERS

Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis

(2013) Stefan Tholen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment

(2013) W Nathaniel Brennen et al.   ENDOCRINE-RELATED CANCER

Fibroblast activation protein-α promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms

(2013) WeiWei Yang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Proteomic identification of protease cleavage sites: cell-biological and biomedical applications

(2013) Hasmik Shahinian et al.   Expert Review of Proteomics

Semaphorin 3F forms an anti-angiogenic barrier in outer retina

(2013) Anima Buehler et al.   FEBS LETTERS

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

(2013) Edward W. Roberts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

(2013) Eric Tran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteolytic Post-translational Modification of Proteins: Proteomic Tools and Methodology

(2013) Lindsay D. Rogers et al.   MOLECULAR & CELLULAR PROTEOMICS

Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells

(2013) Hasmik Shahinian et al.   Molecular Oncology

A Vaccine That Co-Targets Tumor Cells and Cancer Associated Fibroblasts Results in Enhanced Antitumor Activity by Inducing Antigen Spreading

(2013) Stephen Gottschalk et al.   PLoS One

Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis

(2013) Younghun Jung et al.   Nature Communications

Identification of inhibitory scFv antibodies targeting fibroblast activation protein utilizing phage display functional screens

(2012) Jiping Zhang et al.   FASEB JOURNAL

Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein α

(2012) Kalyani Jambunathan et al.   FEBS LETTERS

Cancer-associated fibroblasts as targets for immunotherapy

(2012) Sunitha Kakarla et al.   Immunotherapy

Roles of fibroblasts from the interface zone in invasion, migration, proliferation and apoptosis of gastric adenocarcinoma

(2012) Li-Hui Shan et al.   JOURNAL OF CLINICAL PATHOLOGY

Targeting Carcinoma-Associated Fibroblasts Within the Tumor Stroma With a Fibroblast Activation Protein-Activated Prodrug

(2012) W. N. Brennen et al.   JNCI-Journal of the National Cancer Institute

Deletion of Cysteine Cathepsins B or L Yields Differential Impacts on Murine Skin Proteome and Degradome

(2012) Stefan Tholen et al.   MOLECULAR & CELLULAR PROTEOMICS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Tumor stroma as targets for cancer therapy

(2012) Jing Zhang et al.   PHARMACOLOGY & THERAPEUTICS

Origins of the Tumor Microenvironment: Quantitative Assessment of Adipose-Derived and Bone Marrow–Derived Stroma

(2012) Shannon Kidd et al.   PLoS One

Inhibition of TGF-β/Smad Signaling by BAMBI Blocks Differentiation of Human Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts and Abolishes their Protumor Effects

(2012) Lei Shangguan et al.   STEM CELLS

Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites

(2011) Oliver Schilling et al.   BIOLOGICAL CHEMISTRY

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells

(2011) Hyung-Ok Lee et al.   BMC CANCER

Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions

(2011) Yan Huang et al.   CLINICAL & EXPERIMENTAL METASTASIS

Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata

(2011) Chad E. Brokopp et al.   EUROPEAN HEART JOURNAL

Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α

(2011) Fiona M. Keane et al.   FEBS Journal

Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate

(2011) Chih-Hsiang Huang et al.   JOURNAL OF BIOCHEMISTRY

Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S

(2011) Martin L. Biniossek et al.   JOURNAL OF PROTEOME RESEARCH

Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition

(2011) Corinna Herz et al.   MOLECULAR CARCINOGENESIS

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry

(2011) Oliver Schilling et al.   Nature Protocols

Coordinate action of membrane-type matrix metalloproteinase-1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion

(2010) Hiroshi Sato et al.   CANCER SCIENCE

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Tumour-associated fibroblasts and mesenchymal stem cells: more similarities than differences

(2010) Virgil Paunescu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Role of Tumor Stroma in Cancer Progression and Prognosis: Emphasis on Carcinoma-Associated Fibroblasts and Non-small Cell Lung Cancer

(2010) Roy M. Bremnes et al.   Journal of Thoracic Oncology

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Using Substrate Specificity of Antiplasmin-Cleaving Enzyme for Fibroblast Activation Protein Inhibitor Design

(2009) Kyung N. Lee et al.   BIOCHEMISTRY

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

Tumor angiogenesis and molecular targets for therapy

(2009) Yihai Cao   Frontiers in Bioscience-Landmark

Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice

(2009) Angélica M. Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers

(2009) Silke Lassmann et al.   MODERN PATHOLOGY

Fibroblast Activation Protein and Its Relationship to Clinical Outcome in Pancreatic Adenocarcinoma

(2009) Steven J. Cohen et al.   PANCREAS

Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy?

(2009) Tamas A. Gonda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ProteoWizard: open source software for rapid proteomics tools development

(2008) Darren Kessner et al.   BIOINFORMATICS

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Fibroblast activation protein α identifies mesenchymal stromal cells from human bone marrow

(2008) Sohyun Bae et al.   BRITISH JOURNAL OF HAEMATOLOGY

Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells

(2008) P. J. Mishra et al.   CANCER RESEARCH

Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts

(2008) E. Ostermann et al.   CLINICAL CANCER RESEARCH

Matrix metalloproteinase inhibitors reduce collagen gel contraction and α-smooth muscle actin expression by periodontal ligament cells

(2008) M. M. Bildt et al.   JOURNAL OF PERIODONTAL RESEARCH

Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites

(2008) Oliver Schilling et al.   NATURE BIOTECHNOLOGY

Fibroblast Activation Protein Peptide Substrates Identified from Human Collagen I Derived Gelatin Cleavage Sites†

(2007) Saurabh Aggarwal et al.   BIOCHEMISTRY

Fibroblast activation protein and chronic liver disease

(2007) Xin Maggie Wang   Frontiers in Bioscience-Landmark