Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy

Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines

(2015) Emmanuel S. Akinboye et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pharmacokinetics and toxicology of a fibroblast activation protein (FAP)-activated prodrug in murine xenograft models of human cancer

(2014) W. Nathaniel Brennen et al.   PROSTATE

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

(2014) Wilson Wong et al.   eLife

Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme

(2013) Alberto Diez-Torrubia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate

(2013) Holly Matthews et al.   MALARIA JOURNAL

Design, Synthesis, and Evaluation of pH-Dependent Hydrolyzable Emetine Analogues as Treatment for Prostate Cancer

(2012) Emmanuel S. Akinboye et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Carcinoma-Associated Fibroblasts Within the Tumor Stroma With a Fibroblast Activation Protein-Activated Prodrug

(2012) W. N. Brennen et al.   JNCI-Journal of the National Cancer Institute

Rationale Behind Targeting Fibroblast Activation Protein-Expressing Carcinoma-Associated Fibroblasts as a Novel Chemotherapeutic Strategy

(2012) W. N. Brennen et al.   MOLECULAR CANCER THERAPEUTICS

Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

(2012) S. R. Denmeade et al.   Science Translational Medicine

The dipeptidyl peptidase IV family in cancer and cell biology

(2010) Denise M. T. Yu et al.   FEBS Journal

Optimization of an Albumin-Binding Prodrug of Doxorubicin That Is Cleaved by Prostate-Specific Antigen

(2010) Bakheet Elsadek et al.   ACS Medicinal Chemistry Letters

Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin

(2009) A. M. LeBeau et al.   MOLECULAR CANCER THERAPEUTICS

Fibroblast Activation Protein Peptide Substrates Identified from Human Collagen I Derived Gelatin Cleavage Sites†

(2007) Saurabh Aggarwal et al.   BIOCHEMISTRY