Role of Caenorhabditis elegans AKT-1/2 and SGK-1 in Manganese Toxicity

Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line

(2018) Miles R. Bryan et al.   NEUROTOXICOLOGY

Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species

(2017) Julie A. Hall et al.   PLoS One

Manganese-Stimulated Kisspeptin Is Mediated by the IGF-1/Akt/Mammalian Target of Rapamycin Pathway in the Prepubertal Female Rat

(2016) Vinod K. Srivastava et al.   ENDOCRINOLOGY

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships

(2016) András Zeke et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

AMP-Activated Protein Kinase Regulates Oxidative Metabolism in Caenorhabditis elegans through the NHR-49 and MDT-15 Transcriptional Regulators

(2016) Elizabeth Moreno-Arriola et al.   PLoS One

Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans

(2016) Daiana Silva Avila et al.   BMC Pharmacology & Toxicology

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators

(2015) Rachel Kaletsky et al.   NATURE

Molecular control of arsenite-induced apoptosis in Caenorhabditis elegans: Roles of insulin-like growth factor-1 signaling pathway

(2014) Shunchang Wang et al.   CHEMOSPHERE

Elemental bioimaging of manganese uptake in C. elegans

(2014) Sigrid Große Brinkhaus et al.   Metallomics

Prohibitin-Mediated Lifespan and Mitochondrial Stress Implicate SGK-1, Insulin/IGF and mTORC2 in C. elegans

(2014) Roxani Gatsi et al.   PLoS One

The DAF-16 FOXO Transcription Factor Regulates natc-1 to Modulate Stress Resistance in Caenorhabditis elegans, Linking Insulin/IGF-1 Signaling to Protein N-Terminal Acetylation

(2014) Kurt Warnhoff et al.   PLoS Genetics

DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans

(2014) Jennifer M. A. Tullet et al.   PLoS Genetics

Effects ofCaenorhabditis elegans sgk-1mutations on lifespan, stress resistance, and DAF-16/FoxO regulation

(2013) Albert Tzong-Yang Chen et al.   AGING CELL

Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox

(2013) Fabiano M. Cordova et al.   ARCHIVES OF TOXICOLOGY

Seleno- and Telluro-xylofuranosides attenuate Mn-induced toxicity in C. elegans via the DAF-16/FOXO pathway

(2013) Suzi G.N. Wollenhaupt et al.   FOOD AND CHEMICAL TOXICOLOGY

Serum- and Glucocorticoid-induced Protein Kinase 1 (SGK1) Is Regulated by Store-operated Ca2+Entry and Mediates Cytoprotection against Necrotic Cell Death

(2013) Deanna R. Brickley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans

(2013) Julia Bornhorst et al.   Metallomics

The Nrf2/SKN-1-dependent glutathione S-transferase π homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism

(2013) Raja Settivari et al.   NEUROTOXICOLOGY

A C. elegans model to study human metabolic regulation

(2013) Sarwar Hashmi et al.   Nutrition & Metabolism

Manganese neurotoxicity: new perspectives from behavioral, neuroimaging, and neuropathological studies in humans and non-human primates

(2013) Tomás R. Guilarte   Frontiers in Aging Neuroscience

Calcium signaling surrounding fertilization in the nematode Caenorhabditis elegans

(2012) Gunasekaran Singaravelu et al.   CELL CALCIUM

Organotellurium and organoselenium compounds attenuate Mn-induced toxicity in Caenorhabditis elegans by preventing oxidative stress

(2012) Daiana Silva Avila et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury

(2012) Marcelo Farina et al.   NEUROCHEMISTRY INTERNATIONAL

In Vivo Manganese Exposure Modulates Erk, Akt and Darpp-32 in the Striatum of Developing Rats, and Impairs Their Motor Function

(2012) Fabiano M. Cordova et al.   PLoS One

Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model

(2012) Daiana Silva Ávila et al.   TOXICOLOGY LETTERS

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

(2011) William Mair et al.   NATURE

Insulin signaling promotes germline proliferation in C. elegans

(2010) D. Michaelson et al.   DEVELOPMENT

Environmental Exposure, Obesity, and Parkinson’s Disease: Lessons from Fat and Old Worms

(2010) Layla Aitlhadj et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing

(2010) C. Kenyon   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans

(2010) Alexandre Benedetto et al.   PLoS Genetics

Disease-toxicant screen reveals a neuroprotective interaction between Huntington’s disease and manganese exposure

(2009) B. Blairanne Williams et al.   JOURNAL OF NEUROCHEMISTRY

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

(2009) Michael Aschner et al.   NEUROMOLECULAR MEDICINE

SMF-1, SMF-2 and SMF-3 DMT1 Orthologues Regulate and Are Regulated Differentially by Manganese Levels in C. elegans

(2009) Catherine Au et al.   PLoS One

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL