Article
Biochemistry & Molecular Biology
Alice Filippini, Valentina Salvi, Vincenzo Dattilo, Chiara Magri, Stefania Castrezzati, Robert Veerhuis, Daniela Bosisio, Massimo Gennarelli, Isabella Russo
Summary: The accumulation of amyloid-beta in Alzheimer's disease (AD) brains causes reactive astrogliosis and neuroinflammatory response. This study investigates the role of leucine-rich repeat kinase 2 (LRRK2) in regulating astrocytic activation in response to amyloid-beta(1-42) (A beta(1-42)). The results demonstrate that LRRK2 kinase activity modulates astrocytic reactivity and functions in the presence of A beta(1-42) deposits, suggesting a potential contribution of PD-linked LRRK2 to AD-related neuroinflammation and pathogenesis.
Article
Clinical Neurology
Daniel L. Kober, Melissa D. Stuchell-Brereton, Colin E. Kluender, Hunter B. Dean, Michael R. Strickland, Deborah F. Steinberg, Samantha S. Nelson, Berevan Baban, David M. Holtzman, Carl Frieden, Jennifer Alexander-Brett, Erik D. Roberson, Yuhua Song, Tom J. Brett
Summary: The study using comprehensive biolayer interferometry analysis revealed that TREM2 binds apoE through a protein-mediated mechanism, with slight affinity differences among isoforms; TREM2 and sTREM2 can directly bind mAβ42 and potently inhibit Aβ42 polymerization, suggesting a potential role in preventing AD pathogenesis.
ALZHEIMERS & DEMENTIA
(2021)
Review
Biochemistry & Molecular Biology
Elena Tamagno, Michela Guglielmotto, Valeria Vasciaveo, Massimo Tabaton
Summary: The pathogenesis of Alzheimer's disease involves the accumulation of beta amyloid and vulnerability of the brain to oxidative stress, which are linked to each other. It is difficult to determine which comes first, Aβ or oxidative stress. Evidence suggests that oxidative stress occurs early in the development of Alzheimer's disease and plays a crucial role in the manifestation of clinical and pathological symptoms.
Review
Chemistry, Applied
Zhiyuan Zhang, Shuai Wang, Haining Tan, Pei Yang, Yuanyuan Li, Lingchuan Xu, Baoguo Duan, Yuhong Liu
Summary: This paper reviews recent research on the regulation of natural polysaccharides in Alzheimer's disease (AD) and systematically lists possible intervention pathways of polysaccharides targeting different mechanisms.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Atsushi Michael Kimura, Mayumi Tsuji, Taro Yasumoto, Yukiko Mori, Tatsunori Oguchi, Yuya Tsuji, Masakazu Umino, Asami Umino, Toru Nishikawa, Shiro Nakamura, Tomio Inoue, Yuji Kiuchi, Masahito Yamada, David B. Teplow, Kenjiro Ono
Summary: Accumulation of amyloid beta-protein is a primary mechanism leading to neuronal death in Alzheimer's disease, with protofibrils being a key target for disease-modifying therapy. Previous studies have shown that phenolic compounds like myricetin can inhibit aggregations of beta-amyloid and alpha-synuclein, providing protective effects against AD and Parkinson's disease. This study demonstrates that myricetin can protect against HMW-A beta o-induced neurotoxicity through multiple antioxidant functions, suggesting its potential as a disease-modifying agent for AD.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Royal Patel, Karamjeet Kaur, Shamsher Singh
Summary: Andrographolide (ANDRO) shows neuroprotective effects against ICV-STZ induced AD-like symptoms in rats, improving behavioral deficits and alterations in biochemical, neuroinflammatory mediators, and neurotransmitters in the hippocampus.
INFLAMMOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Swati Som, Justin Antony, SPalanisamy Dhanabal, Sivasankaran Ponnusankar
Summary: This study found that diosgenin has a neuroprotective effect in a rat model of Alzheimer's disease, improving learning and memory, reducing plaque load, oxidative stress, neuroinflammation, and acetylcholinesterase activity.
METABOLIC BRAIN DISEASE
(2022)
Article
Behavioral Sciences
Camila Andre Cazarin, Ana Paula Dalmagro, Ana Elisa Goncalves, Thaise Boeing, Luisa Mota da Silva, Rogerio Correa, Luiz Carlos Klein-Junior, Bernardo Carlesso Pinto, Thais Savoldi Lorenzett, Thales Uchoa da Costa Sobrinho, Angelo de Fatima, Tiago Coelho de Assis Lage, Sergio Antonio Fernandes, Marcia Maria de Souza
Summary: This study investigated the effects of UA enantiomers on cognitive deficits and neuroinflammation in mice with AD. The results showed that UA improved learning and memory, reduced oxidative stress markers, decreased neuroinflammation, and restored cognitive deficits induced by A beta 1-42 administration in mice.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Neurosciences
Musa O. Iliyasu, Sunday A. Musa, Sunday B. Oladele, Abdullahi I. Iliya
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by tau pathology and accumulation of amyloid-beta (Aβ). Aβ aggregation leads to oxidative stress, inflammatory cascade, and caspase activation, causing hyperphosphorylation of tau protein and formation of neurofibrillary tangles (NFTs). Acetylcholine degradation is accelerated, resulting in neurotransmitter deficiency and cognitive impairment. AD research is necessary to identify novel compounds for treatment and prevention, including those targeting Aβ, tau, neurotransmitter modulation, neuroinflammation, neuroprotection, and cognition enhancement.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Benita Wiatrak, Paulina Jawien, Agnieszka Matuszewska, Adam Szelag, Adriana Kubis-Kubiak
Summary: This study aimed to investigate the impact of amyloid fragments on oxidative stress and found that amyloid fragments have antioxidant properties, protecting neurons from neuroinflammation-induced damage. Among the tested fragments, the 1-40 fragment showed a stronger antioxidant effect.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Anam Shabbir, Kanwal Rehman, Moazzama Akbar, Muhammad Sajid Hamid Akash
Summary: This review article discusses the potential of curcuminoids as therapeutic agents for Alzheimer's disease, summarizing various in vitro and in vivo research studies. Curcuminoids have shown promising results in inhibiting key pathological processes associated with the disease, and further research is needed.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Changjiang Li, Na Wang, Guodong Zheng, Licong Yang
Summary: A Res-selenium-peptide nanocomposite was developed to improve cognitive dysfunction in AD model mice by reducing Aβ aggregation, inhibiting Aβ deposition, decreasing oxidative stress and inflammation, and alleviating gut microbiota disorder.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Md. Sohanur Rahman, Md. Sahab Uddin, Md. Ataur Rahman, Md. Samsuzzaman, Tapan Behl, Abdul Hafeez, Asma Perveen, George E. Barreto, Ghulam Md. Ashraf
Summary: Monoamine oxidases (MAOs) are crucial enzymes in neurotransmitter metabolism, with impaired function associated with various brain diseases. Particularly, in Alzheimer's disease, MAO plays a critical role in the development of pathology.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Engineering, Environmental
Youcong Gong, Anlian Huang, Xian Guo, Zhi Jia, Xu Chen, Xufeng Zhu, Yu Xia, Jie Liu, Ying Xu, Xiuying Qin
Summary: The multifunctional selenium-polydopamine nanozyme reported in this study effectively blocks the entangled dynamic circulation between Aβ and neuroinflammation through broad-spectrum antioxidant activity. This nanozyme protects cells from oxidative damage, improves neuroinflammation, reduces Aβ burden, and saves cognitive impairment.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Endocrinology & Metabolism
Mahmoud Khaleghi-Mehr, Alireza-Azizzadeh Delshad, Sepideh Shafie-Damavandi, Mehrdad Roghani
Summary: This study aimed to evaluate the protective effect of metformin against A beta(1-40)-induced cognitive impairment. The results showed that metformin improved cognitive function in rats and attenuated hippocampal damage such as oxidative stress, apoptosis, and inflammation. This study reveals the neuroprotective and anti-dementia properties of metformin.
METABOLIC BRAIN DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Nady Braidy, Jade Berg, James Clement, Fatemeh Khorshidi, Anne Poljak, Tharusha Jayasena, Ross Grant, Perminder Sachdev
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Review
Cell Biology
Mohammad Hosein Farzaei, Roodabeh Bahramsoltani, Zahra Abbasabadi, Nady Braidy, Seyed Mohammad Nabavi
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Neurosciences
Mona Dehhaghi, Vanessa Tan, Benjamin Heng, Nady Braidy, Fatemeh Mohammadipanah, Gilles J. Guillemin
NEUROTOXICITY RESEARCH
(2019)
Article
Geriatrics & Gerontology
James Clement, Matthew Wong, Anne Poljak, Perminder Sachdev, Nady Braidy
REJUVENATION RESEARCH
(2019)
Article
Cell Biology
Mustafa Sevindik, Hasan Akgul, Zeliha Selamoglu, Nady Braidy
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Biology
Matthew W. K. Wong, Anbupalam Thalamuthu, Nady Braidy, Karen A. Mather, Yue Liu, Liliana Ciobanu, Bernhardt T. Baune, Nicola J. Armstrong, John Kwok, Peter Schofield, Margaret J. Wright, David Ames, Russell Pickford, Teresa Lee, Anne Poljak, Perminder S. Sachdev
Article
Neurosciences
Nady Braidy, Hayden Alicajic, David Pow, Jason Smith, Bat-Erdene Jugder, Bruce J. Brew, Joseph A. Nicolazzo, Gilles J. Guillemin
Summary: In Alzheimer's disease, excessive QUIN accumulation in the brain affects glutamate uptake via EAAT3, with QUIN uptake involving EAAT3 and potential targets to reduce QUIN-induced excitotoxicity being identified through this study.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Maria D. Villalva, Vipul Agarwal, Marina Ulanova, Perminder S. Sachdev, Nady Braidy
Summary: Quantum dots, as nanoparticles, hold promising applications in neurodegenerative diseases due to their unique optical properties and versatility. Their ability to conjugate to various biomolecules while maintaining a nanoscale size makes them a potential tool in Alzheimer's disease diagnosis and therapy.
Article
Psychiatry
Yue Liu, Anbupalam Thalamuthu, Karen A. Mather, John Crawford, Marina Ulanova, Matthew Wai Kin Wong, Russell Pickford, Perminder S. Sachdev, Nady Braidy
Summary: Lipidomics research in Alzheimer's disease identifies specific lipid species that are dysregulated in AD patients and may aid in distinguishing them from healthy controls. Certain lipid classes, such as sphingomyelins, cholesterol esters, and triglycerides, show good classification accuracy in relation to AD. Furthermore, the study reveals associations between plasma lipid profiles and genetic risk factors for AD, shedding light on the pathobiology of the disease.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Biology
Nady Braidy, Maria D. Villalva, Ross Grant
Summary: Nicotinamide adenine dinucleotide (NAD(+)) and its metabolome (NADome) are crucial for cellular homeostasis, with altered levels potentially indicating poor metabolic function. Recent liquid chromatography mass spectrometry (LC-MS) techniques have been developed to accurately measure NADome concentrations in biological samples such as blood, CSF, and urine. These methods offer a rapid, reliable, and sensitive means of assessing NADome levels and correlating them with various biochemical processes and potential interventions for ageing and neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Shannon Chiang, Nady Braidy, Sanaz Maleki, Sean Lal, Des R. Richardson, Michael L. -H. Huang
Summary: This study investigated mitochondrial homeostasis in Friedreich's ataxia (FA) cardiomyopathy, revealing significant changes in key mitochondrial homeostatic mechanisms in the hearts of frataxin-deficient mice. The findings demonstrated dysfunction in mitochondrial proliferation, NAD+ metabolism, and mitochondrial dynamics, with an accumulation of Pink1/Parkin and increased autophagic/mitophagic flux. This mechanistic dissection offers insights into potential treatments targeting mitochondrial homeostasis and NAD+ metabolism in FA and other cardiodegenerative diseases.
Review
Geriatrics & Gerontology
Tessa Helman, Nady Braidy
Summary: The role of nicotinamide adenine dinucleotide (NAD+) in aging and its links to chronic diseases are discussed in this review. The mechanisms behind age-associated NAD+ decline are not well understood, but supplements aimed at increasing NAD+ levels are becoming popular. The clinical utility and benefits of NAD+ precursors in attenuating NAD+ decline and age-related disorders are explored.
Article
Cell Biology
Marina Ulanova, Lucy Gloag, Andre Bongers, Chul-Kyu Kim, Hong Thien Kim Duong, Ha Na Kim, John Justin Gooding, Richard D. Tilley, Joanna Biazik, Wei Wen, Perminder S. Sachdev, Nady Braidy, Alexander E. Kalyuzhny
Summary: Nanoparticle-based magnetic contrast agents have been developed for early non-invasive diagnosis of Alzheimer's disease (AD) using magnetic resonance imaging (MRI). This study developed a biocompatible magnetic nanoparticle targeted to amyloid beta (A beta) plaques to enhance the sensitivity of T2-weighted MRI for imaging of amyloid pathology in AD. The nanoparticles showed no significant cytotoxicity and were able to bind to amyloid species. The study provides promising preliminary results for the development of a targeted non-invasive method for early AD diagnosis using contrast-enhanced MRI.
Article
Mycology
Mustafa Sevindik, Hasan Akgul, Zeliha Selamoglu, Nady Braidy
Summary: The study on Octaviania asterosperma revealed its phenolic composition and effects, such as antioxidant, antimicrobial, and antigenotoxic effects. The methanol extracts contained various phenolic compounds and showed potential in protecting neuronal cells from oxidative DNA damage. Additionally, pre-treatment with the extract demonstrated neuroprotective effects against neurodegenerative disorders.
MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY
(2021)
Article
Neurosciences
Meena Kishore Sakharkar, Sarinder Kaur Dhillon, Karthic Rajamanickam, Benjamin Heng, Nady Braidy, Gilles J. Guillemin, Jian Yang
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2020)