Epothilone D accelerates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Microtubule stabilization promoted axonal regeneration and functional recovery after spinal root avulsion

(2017) Heng Li et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis

(2016) Jayden A. Clark et al.   JOURNAL OF CHEMICAL NEUROANATOMY

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

(2016) Kevin P Kenna et al.   NATURE GENETICS

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

(2016) Monika S. Brill et al.   NEURON

The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders

(2016) Jessica Eira et al.   PROGRESS IN NEUROBIOLOGY

A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease

(2016) Jayden A. Clark et al.   Frontiers in Cellular Neuroscience

Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons

(2016) Eun-Hae Jang et al.   NEURAL PLASTICITY

The Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic Paraplegias

(2016) Felipe J. Bodaleo et al.   Frontiers in Molecular Neuroscience

Genetic causes of amyotrophic lateral sclerosis: New genetic analysis methodologies entailing new opportunities and challenges

(2015) Giuseppe Marangi et al.   BRAIN RESEARCH

Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity

(2015) C. A. Blizzard et al.   Disease Models & Mechanisms

Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes

(2015) Nataliya Golovyashkina et al.   Molecular Neurodegeneration

Effects of Paclitaxel and Eribulin in Mouse Sciatic Nerve: A Microtubule-Based Rationale for the Differential Induction of Chemotherapy-Induced Peripheral Neuropathy

(2015) Sarah J. Benbow et al.   NEUROTOXICITY RESEARCH

Edaravone, a Free Radical Scavenger, Delayed Symptomatic and Pathological Progression of Motor Neuron Disease in the Wobbler Mouse

(2015) Ken Ikeda et al.   PLoS One

Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

(2015) J. Ruschel et al.   SCIENCE

Neurodegeneration and microtubule dynamics: death by a thousand cuts

(2015) Jyoti Dubey et al.   Frontiers in Cellular Neuroscience

Epothilones in epithelial ovarian, fallopian tube, or primary peritoneal cancer: a systematic review

(2015) Flora Zagouri et al.   OncoTargets and Therapy

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

(2014) Kurt R. Brunden et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS

(2014) Bradley N. Smith et al.   NEURON

Targeting the motor end plates in the mouse hindlimb gives access to a greater number of spinal cord motor neurons: An approach to maximize retrograde transport

(2014) R. Mohan et al.   NEUROSCIENCE

An assay to image neuronal microtubule dynamics in mice

(2014) Tatjana Kleele et al.   Nature Communications

ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease

(2014) Elizabeth B. Moloney et al.   Frontiers in Neuroscience

Riluzole exerts central and peripheral modulating effects in amyotrophic lateral sclerosis

(2013) Steve Vucic et al.   BRAIN

Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS

(2013) Ines Taes et al.   HUMAN MOLECULAR GENETICS

HDAC6 Regulates Mutant SOD1 Aggregation through Two SMIR Motifs and Tubulin Acetylation

(2013) Jozsef Gal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon

(2013) Marek Ma   NEUROBIOLOGY OF DISEASE

Microtubule Alterations Occur Early in Experimental Parkinsonism and The Microtubule Stabilizer Epothilone D Is Neuroprotective

(2013) Daniele Cartelli et al.   Scientific Reports

Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol

(2013) Anna King et al.   Acta Neuropathologica Communications

Cerebrospinal fluid–based kinetic biomarkers of axonal transport in monitoring neurodegeneration

(2012) Patrizia Fanara et al.   JOURNAL OF CLINICAL INVESTIGATION

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Vertebral landmarks for the identification of spinal cord segments in the mouse

(2012) Megan Harrison et al.   NEUROIMAGE

Reassessment of motor-behavioural test analyses enables the detection of early disease-onset in a transgenic mouse model of amyotrophic lateral sclerosis

(2011) Sabrina Schäfer et al.   BEHAVIOURAL BRAIN RESEARCH

Epothilone-Induced Peripheral Neuropathy: A Review of Current Knowledge

(2011) Andreas A. Argyriou et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

(2011) F. Hellal et al.   SCIENCE

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

(2010) K. R. Brunden et al.   JOURNAL OF NEUROSCIENCE

Deficits in axonal transport precede ALS symptoms in vivo

(2010) L. G. Bilsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial amyotrophic lateral sclerosis-linked mutant SOD1 aberrantly interacts with tubulin

(2009) Tomohiro Kabuta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome

(2009) M. Galante et al.   HUMAN MOLECULAR GENETICS

Gamma and alpha motor neurons distinguished by expression of transcription factor Err3

(2009) A. Friese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, power, and interpretation of studies in the standard murine model of ALS

(2008) Sean Scott et al.   Amyotrophic Lateral Sclerosis

Neuromuscular junction integrity after chronic nerve compression injury

(2008) Tahseen Mozaffar et al.   JOURNAL OF ORTHOPAEDIC RESEARCH