The Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic Paraplegias

Hierarchical Microtubule Organization Controls Axon Caliber and Transport and Determines Synaptic Structure and Stability

(2015) Raiko Stephan et al.   DEVELOPMENTAL CELL

A marginal band of microtubules transports and organizes mitochondria in retinal bipolar synaptic terminals

(2015) Malkolm Graffe et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular Remodeling of the Presynaptic Active Zone of Drosophila Photoreceptors via Activity-Dependent Feedback

(2015) Atsushi Sugie et al.   NEURON

BMP signaling and microtubule organization regulate synaptic strength

(2015) R.W. Ball et al.   NEUROSCIENCE

Independent role for presynaptic FMRP revealed by anFMR1missense mutation associated with intellectual disability and seizures

(2015) Leila K. Myrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic

(2014) J. E. C. Jepson et al.   DEVELOPMENT

Microtubule-severing protein Katanin regulates neuromuscular junction development and dendritic elaboration in Drosophila

(2014) C.-X. Mao et al.   DEVELOPMENT

Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton

(2014) A.-M. Luchtenborg et al.   DEVELOPMENT

Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP)

(2014) S. L. Baxter et al.   Disease Models & Mechanisms

Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2

(2014) Victoria Bulat et al.   JOURNAL OF CELL BIOLOGY

A Presynaptic Role of Microtubule-Associated Protein 1/Futsch in Drosophila: Regulation of Active Zone Number and Neurotransmitter Release

(2014) S. Lepicard et al.   JOURNAL OF NEUROSCIENCE

Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a Drosophila Model of Amyotrophic Lateral Sclerosis

(2014) A. N. Coyne et al.   JOURNAL OF NEUROSCIENCE

The proteome of the presynaptic active zone from mouse brain

(2014) Jens Weingarten et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A TRPV Channel in Drosophila Motor Neurons Regulates Presynaptic Resting Ca2+ Levels, Synapse Growth, and Synaptic Transmission

(2014) Ching-On Wong et al.   NEURON

CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradation

(2014) María A. Gandini et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis

(2014) C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density

(2014) Laurent Ferron et al.   Nature Communications

Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila

(2013) S. H. Friedman et al.   Disease Models & Mechanisms

Spartin Regulates Synaptic Growth and Neuronal Survival by Inhibiting BMP-Mediated Microtubule Stabilization

(2013) Minyeop Nahm et al.   NEURON

FMRP Regulates Neurotransmitter Release and Synaptic Information Transmission by Modulating Action Potential Duration via BK Channels

(2013) Pan-Yue Deng et al.   NEURON

Molecular Profiling of Synaptic Vesicle Docking Sites Reveals Novel Proteins but Few Differences between Glutamatergic and GABAergic Synapses

(2013) Janina Boyken et al.   NEURON

Loss of Spastin Function Results in Disease-Specific Axonal Defects in Human Pluripotent Stem Cell-Based Models of Hereditary Spastic Paraplegia

(2013) Kyle R. Denton et al.   STEM CELLS

Development and plasticity of the Drosophila larval neuromuscular junction

(2013) Kaushiki P. Menon et al.   Wiley Interdisciplinary Reviews-Developmental Biology

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

(2012) Daniel C. Berwick et al.   HUMAN MOLECULAR GENETICS

FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption

(2012) Inna V. Nechipurenko et al.   JOURNAL OF CELL BIOLOGY

Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice

(2012) Timothy J. Mosca et al.   NATURE

The Presynaptic Active Zone

(2012) Thomas C. Südhof   NEURON

Molecular organization and plasticity of the cytomatrix at the active zone

(2011) Eckart D Gundelfinger et al.   CURRENT OPINION IN NEUROBIOLOGY

Loss ofDrosophila melanogaster p21-activated kinase 3Suppresses Defects in Synapse Structure and Function Caused byspastinMutations

(2011) Emily F. Ozdowski et al.   GENETICS

BDNF-Induced Increase of PSD-95 in Dendritic Spines Requires Dynamic Microtubule Invasions

(2011) X. Hu et al.   JOURNAL OF NEUROSCIENCE

The Presynaptic Dense Projection of the Caenorhabiditis elegans Cholinergic Neuromuscular Junction Localizes Synaptic Vesicles at the Active Zone through SYD-2/Liprin and UNC-10/RIM-Dependent Interactions

(2011) C. Stigloher et al.   JOURNAL OF NEUROSCIENCE

TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization

(2011) Vinay K. Godena et al.   PLoS One

Dynamic Microtubules Promote Synaptic NMDA Receptor-Dependent Spine Enlargement

(2011) Elliott B. Merriam et al.   PLoS One

SMN Requirement for Synaptic Vesicle, Active Zone and Microtubule Postnatal Organization in Motor Nerve Terminals

(2011) Laura Torres-Benito et al.   PLoS One

Flightless flies: Drosophila models of neuromuscular disease

(2010) Thomas E. Lloyd et al.   Annals of the New York Academy of Sciences

Bicaudal-D Regulates Fragile X Mental Retardation Protein Levels, Motility, and Function during Neuronal Morphogenesis

(2010) Ambra Bianco et al.   CURRENT BIOLOGY

The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases

(2010) Vafa Bayat et al.   CURRENT OPINION IN NEUROBIOLOGY

Activin signaling functions upstream of Gbb to regulate synaptic growth at the Drosophila neuromuscular junction

(2010) J.E. Ellis et al.   DEVELOPMENTAL BIOLOGY

Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling

(2010) Xuan Li et al.   EMBO JOURNAL

Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia

(2010) Fang Du et al.   HUMAN MOLECULAR GENETICS

Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria

(2010) Aiyu Yao et al.   HUMAN MOLECULAR GENETICS

The Micro-Architecture of Mitochondria at Active Zones: Electron Tomography Reveals Novel Anchoring Scaffolds and Cristae Structured for High-Rate Metabolism

(2010) G. A. Perkins et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Kinase Regulates Synaptic Morphology through Distinct Substrates at the Presynaptic and Postsynaptic Compartments of the Drosophila Neuromuscular Junction

(2010) S. Lee et al.   JOURNAL OF NEUROSCIENCE

The synapsins: Key actors of synapse function and plasticity

(2010) F. Cesca et al.   PROGRESS IN NEUROBIOLOGY

Drosophila melanogaster as a Model Organism of Brain Diseases

(2009) Astrid Jeibmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton

(2009) Catherine M. Massaro et al.   JOURNAL OF CELL BIOLOGY

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

(2009) Paul R. Kasher et al.   JOURNAL OF NEUROCHEMISTRY

The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain Circuits

(2009) S. B. Christie et al.   JOURNAL OF NEUROSCIENCE

Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function

(2009) Lorena Varela-Nallar et al.   Neural Development

Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity

(2009) Jacek Jaworski et al.   NEURON

Temporal requirements of the fragile X mental retardation protein in modulating circadian clock circuit synaptic architecture

(2009) Cheryl L. Gatto   Frontiers in Neural Circuits

The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels

(2008) Marco Morciano et al.   JOURNAL OF NEUROCHEMISTRY

Activity-Dependent Dynamic Microtubule Invasion of Dendritic Spines

(2008) X. Hu et al.   JOURNAL OF NEUROSCIENCE

Presynaptic Local Signaling by a Canonical Wingless Pathway Regulates Development of the Drosophila Neuromuscular Junction

(2008) C. Miech et al.   JOURNAL OF NEUROSCIENCE

The Role of MAP1A Light Chain 2 in Synaptic Surface Retention of CaV2.2 Channels in Hippocampal Neurons

(2008) A. G. M. Leenders et al.   JOURNAL OF NEUROSCIENCE

Formin-Dependent Synaptic Growth: Evidence That Dlar Signals via Diaphanous to Modulate Synaptic Actin and Dynamic Pioneer Microtubules

(2008) C. Pawson et al.   JOURNAL OF NEUROSCIENCE

Drosophila Ankyrin 2 Is Required for Synaptic Stability

(2008) Iris Koch et al.   NEURON

A Presynaptic Giant Ankyrin Stabilizes the NMJ through Regulation of Presynaptic Microtubules and Transsynaptic Cell Adhesion

(2008) Jan Pielage et al.   NEURON

A Drosophila Model of ALS: Human ALS-Associated Mutation in VAP33A Suggests a Dominant Negative Mechanism

(2008) Anuradha Ratnaparkhi et al.   PLoS One

A Drosophila model for LRRK2-linked parkinsonism

(2008) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA