A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease

Intracellular and Extracellular Roles for Tau in Neurodegenerative Disease

(2018) Diane P. Hanger et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurofilament depletion improves microtubule dynamics via modulation of Stat3/stathmin signaling

(2016) Preeti Yadav et al.   ACTA NEUROPATHOLOGICA

Stability properties of neuronal microtubules

(2016) Peter W. Baas et al.   Cytoskeleton

Oxidative stress decreases microtubule growth and stability in ventricular myocytes

(2016) Benjamin M.L. Drum et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interactions between the Microtubule Binding Protein EB1 and F-Actin

(2016) Emily O. Alberico et al.   JOURNAL OF MOLECULAR BIOLOGY

Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansions

(2016) Tiffany W. Todd et al.   JOURNAL OF NEUROCHEMISTRY

Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation

(2016) K. W. Yau et al.   JOURNAL OF NEUROSCIENCE

Genetic causes of amyotrophic lateral sclerosis: New genetic analysis methodologies entailing new opportunities and challenges

(2015) Giuseppe Marangi et al.   BRAIN RESEARCH

Nerve growth factor promotes reorganization of the axonal microtubule array at sites of axon collateral branching

(2015) Andrea Ketschek et al.   Developmental Neurobiology

Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity

(2015) C. A. Blizzard et al.   Disease Models & Mechanisms

Emerging mechanisms of molecular pathology in ALS

(2015) Owen M. Peters et al.   JOURNAL OF CLINICAL INVESTIGATION

Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells

(2015) Carmen Laura Sayas et al.   JOURNAL OF NEUROCHEMISTRY

The expanding syndrome of amyotrophic lateral sclerosis: a clinical and molecular odyssey

(2015) Martin R Turner et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Uncoupling of Protein Aggregation and Neurodegeneration in a Mouse Amyotrophic Lateral Sclerosis Model

(2015) Joo-Yong Lee et al.   Neurodegenerative Diseases

TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays

(2015) Sam F.B. van Beuningen et al.   NEURON

Neurodegeneration and microtubule dynamics: death by a thousand cuts

(2015) Jyoti Dubey et al.   Frontiers in Cellular Neuroscience

Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking

(2015) Carlos Wilson et al.   Frontiers in Cellular Neuroscience

The MAP1B case: An old MAP that is new again

(2014) David Villarroel-Campos et al.   Developmental Neurobiology

The tubulin code: Molecular components, readout mechanisms, and functions

(2014) Carsten Janke   JOURNAL OF CELL BIOLOGY

Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a Drosophila Model of Amyotrophic Lateral Sclerosis

(2014) A. N. Coyne et al.   JOURNAL OF NEUROSCIENCE

Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

(2014) Ilie-Cosmin Stancu et al.   Molecular Neurodegeneration

Beyond taxol: microtubule-based strategies for promoting nerve regeneration after injury

(2014) PeterW Baas   Neural Regeneration Research

Neuronal transport defects of the MAP6 KO mouse – a model of schizophrenia – and alleviation by Epothilone D treatment, as observed using MEMRI

(2014) Alexia Daoust et al.   NEUROIMAGE

Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations

(2014) Nael H. Alami et al.   NEURON

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS

(2014) Bradley N. Smith et al.   NEURON

SOD1 Function and Its Implications for Amyotrophic Lateral Sclerosis Pathology

(2014) Rosie K. A. Bunton-Stasyshyn et al.   NEUROSCIENTIST

The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases

(2014) Cristian A. Droppelmann et al.   Frontiers in Cellular Neuroscience

Deregulated expression of cytoskeleton related genes in the spinal cord and sciatic nerve of presymptomatic SOD1G93A Amyotrophic Lateral Sclerosis mouse model

(2014) Jessica R. Maximino et al.   Frontiers in Cellular Neuroscience

An assay to image neuronal microtubule dynamics in mice

(2014) Tatjana Kleele et al.   Nature Communications

The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs

(2013) Timothy P. Levine et al.   BIOINFORMATICS

Beyond taxol: microtubule-based treatment of disease and injury of the nervous system

(2013) Peter W. Baas et al.   BRAIN

MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells

(2013) Elena Tortosa et al.   EMBO JOURNAL

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

(2013) Benjamin M. Schwenk et al.   EMBO JOURNAL

Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS

(2013) Ines Taes et al.   HUMAN MOLECULAR GENETICS

HDAC6 Regulates Mutant SOD1 Aggregation through Two SMIR Motifs and Tubulin Acetylation

(2013) Jozsef Gal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure

(2013) Stuart C. Howes et al.   MOLECULAR BIOLOGY OF THE CELL

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Microtubule Stability in the Axon: New Answers to an Old Mystery

(2013) Peter W. Baas   NEURON

Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS

(2013) Peter E.A. Ash et al.   NEURON

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Mitochondrial swelling and microtubule depolymerization are associated with energy depletion in axon degeneration

(2013) J.Y. Park et al.   NEUROSCIENCE

Cortical Thinning and Clinical Heterogeneity in Amyotrophic Lateral Sclerosis

(2013) Domenico Maria Mezzapesa et al.   PLoS One

The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

(2013) K. Mori et al.   SCIENCE

Microtubule dynamics in neuronal morphogenesis

(2013) A. Sakakibara et al.   Open Biology

Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol

(2013) Anna King et al.   Acta Neuropathologica Communications

The genetics and neuropathology of amyotrophic lateral sclerosis

(2012) Ammar Al-Chalabi et al.   ACTA NEUROPATHOLOGICA

Mutations in the autoregulatory domain of β-tubulin 4a cause hereditary dystonia

(2012) Joshua Hersheson et al.   ANNALS OF NEUROLOGY

Cooperative effect of p150Glued and microtubule stabilization to suppress excitotoxicity-induced axon degeneration

(2012) Takeshi Fujiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation

(2012) Viswanath Das et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth

(2012) Claudia Fallini et al.   HUMAN MOLECULAR GENETICS

Disruption of Axonal Transport in Motor Neuron Diseases

(2012) Kensuke Ikenaka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Basis for Specific Regulation of Neuronal Kinesin-3 Motors by Doublecortin Family Proteins

(2012) Judy S. Liu et al.   MOLECULAR CELL

Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases

(2012) Cheng Fang et al.   Molecular Neurodegeneration

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

(2012) Clotilde Lagier-Tourenne et al.   NATURE NEUROSCIENCE

ArrayExpress update—trends in database growth and links to data analysis tools

(2012) Gabriella Rustici et al.   NUCLEIC ACIDS RESEARCH

Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations

(2011) Max A Tischfield et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Microtubule-associated Protein 1B (MAP1B) Is Required for Dendritic Spine Development and Synaptic Maturation

(2011) Elena Tortosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Casein kinase I delta controls centrosome positioning during T cell activation

(2011) Deborah Zyss et al.   JOURNAL OF CELL BIOLOGY

MAP1B enhances microtubule assembly rates and axon extension rates in developing neurons

(2011) Stephen R. Tymanskyj et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

CK1 activates minus-end–directed transport of membrane organelles along microtubules

(2011) Kazuho Ikeda et al.   MOLECULAR BIOLOGY OF THE CELL

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

(2011) Constantin d'Ydewalle et al.   NATURE MEDICINE

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43

(2011) James R Tollervey et al.   NATURE NEUROSCIENCE

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

(2011) Peter M. Andersen et al.   Nature Reviews Neurology

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel

(2011) Or A. Shemesh et al.   NEUROBIOLOGY OF DISEASE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Effect of protein glutathionylation on neuronal cytoskeleton: a potential link to neurodegeneration

(2011) B. Carletti et al.   NEUROSCIENCE

Distinct α- and β-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the ‘multi-tubulin’ hypothesis

(2010) Max A. Tischfield et al.   BIOSCIENCE REPORTS

Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFδ/δ mouse model of amyotrophic lateral sclerosis

(2010) Alice Brockington et al.   BMC GENOMICS

Hooks and comets: The story of microtubule polarity orientation in the neuron

(2010) Peter W. Baas et al.   Developmental Neurobiology

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

(2010) Dorothee Dormann et al.   EMBO JOURNAL

Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases

(2010) H. Sudo et al.   HUMAN MOLECULAR GENETICS

Amyotrophic Lateral Sclerosis-associated Proteins TDP-43 and FUS/TLS Function in a Common Biochemical Complex to Co-regulate HDAC6 mRNA

(2010) Sang Hwa Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+-induced neurodegeneration

(2010) Daniele Cartelli et al.   JOURNAL OF NEUROCHEMISTRY

MAP1B Regulates Axonal Development by Modulating Rho-GTPase Rac1 Activity

(2010) Carolina Montenegro-Venegas et al.   MOLECULAR BIOLOGY OF THE CELL

Tau levels do not influence human ALS or motor neuron degeneration in the SOD1G93A mouse

(2010) I. Taes et al.   NEUROLOGY

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies

(2010) Kurt R. Brunden et al.   PHARMACOLOGICAL RESEARCH

Deficits in axonal transport precede ALS symptoms in vivo

(2010) L. G. Bilsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton

(2010) Carsten Janke et al.   TRENDS IN NEUROSCIENCES

Axonal Mitochondrial Clusters Containing Mutant SOD1 in Transgenic Models of ALS

(2009) Jose R. Sotelo-Silveira et al.   ANTIOXIDANTS & REDOX SIGNALING

Familial amyotrophic lateral sclerosis-linked mutant SOD1 aberrantly interacts with tubulin

(2009) Tomohiro Kabuta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system

(2009) James C. Vickers et al.   BRAIN RESEARCH BULLETIN

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

(2009) Fabienne C Fiesel et al.   EMBO JOURNAL

Depletion of TDP-43 affectsDrosophila motoneuronsterminal synapsis and locomotive behavior

(2009) Fabian Feiguin et al.   FEBS LETTERS

Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation

(2009) Erich B. Tahara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?

(2009) Frank Gillardon   JOURNAL OF NEUROCHEMISTRY

Chemotherapy-Induced Peripheral Neuropathy as a Predictor of Neuropathic Pain in Breast Cancer Patients Previously Treated With Paclitaxel

(2009) Cielito C. Reyes-Gibby et al.   JOURNAL OF PAIN

Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery

(2009) Brian D. Freibaum et al.   JOURNAL OF PROTEOME RESEARCH

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis

(2009) J. E. Landers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

TDP-43A315T mutation in familial motor neuron disease

(2008) Michael A. Gitcho et al.   ANNALS OF NEUROLOGY

Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3

(2008) Minako Tateno et al.   HUMAN MOLECULAR GENETICS

The formin mDia2 stabilizes microtubules independently of its actin nucleation activity

(2008) Francesca Bartolini et al.   JOURNAL OF CELL BIOLOGY

Retrograde axonal transport and motor neuron disease

(2008) Anna-Lena Strm et al.   JOURNAL OF NEUROCHEMISTRY

Reactive oxygen species regulate F-actin dynamics in neuronal growth cones and neurite outgrowth

(2008) Vidhya Munnamalai et al.   JOURNAL OF NEUROCHEMISTRY

Motor Neuron Disease Occurring in a Mutant Dynactin Mouse Model Is Characterized by Defects in Vesicular Trafficking

(2008) F. M. Laird et al.   JOURNAL OF NEUROSCIENCE

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE

Abnormal development of the human cerebral cortex: genetics, functional consequences and treatment options

(2008) Renzo Guerrini et al.   TRENDS IN NEUROSCIENCES