Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels

Moderate treadmill exercise ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway

(2018) Mohammad Azimi et al.   PEPTIDES

Physical Exercise Protects Against Alzheimer's Disease in 3xTg-AD Mice

(2018) Yoelvis García-Mesa et al.   JOURNAL OF ALZHEIMERS DISEASE

Resveratrol ameliorates spatial learning memory impairment induced by Aβ 1–42 in rats

(2017) Rui Wang et al.   NEUROSCIENCE

Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial

(2017) Jill K. Morris et al.   PLoS One

Interleukin-6 increases the expression and activity of insulin-degrading enzyme

(2017) Mirian A. Kurauti et al.   Scientific Reports

Steroid sulfatase inhibitor DU-14 protects spatial memory and synaptic plasticity from disruption by amyloid β protein in male rats

(2016) Xing-Hua Yue et al.   HORMONES AND BEHAVIOR

A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer’s Disease

(2016) Ewelina Maliszewska-Cyna et al.   JOURNAL OF ALZHEIMERS DISEASE

Age-associated physiological and pathological changes at the blood–brain barrier: A review

(2016) Franciska Erdő et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease

(2016) Kaitlin M. Moore et al.   NEUROBIOLOGY OF DISEASE

Alzheimer’s disease like pathology induced six weeks after aggregated amyloid-beta injection in rats: increased oxidative stress and impaired long-term memory with anxiety-like behavior

(2016) Sheetal Sharma et al.   NEUROLOGICAL RESEARCH

The effects of GABAA and NMDA receptors in the shell–accumbens on spatial memory of METH-treated rats

(2016) Soomaayeh Heysieattalab et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Hippocampal Injections of Oligomeric Amyloid β-peptide (1–42) Induce Selective Working Memory Deficits and Long-lasting Alterations of ERK Signaling Pathway

(2016) Pierre Faucher et al.   Frontiers in Aging Neuroscience

Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats

(2015) Loqman A. Mohamed et al.   ACS Chemical Neuroscience

Treadmill Running Reverses Cognitive Declines due to Alzheimer Disease

(2015) JINKYUNG CHO et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer’s disease (APP/PS1) transgenic mice

(2015) Tzu-Wei Lin et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Treadmill exercise enhances synaptic plasticity, but does not alter β-amyloid deposition in hippocampi of aged APP/PS1 transgenic mice

(2015) G. Zhao et al.   NEUROSCIENCE

Non-selective NSAIDs improve the amyloid-β-mediated suppression of memory and synaptic plasticity

(2015) Jafar Doost Mohammadpour et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus

(2015) Tahir Ali et al.   Scientific Reports

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

(2015) Ying Y. Jean et al.   Jove-Journal of Visualized Experiments

Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway

(2015) Lu Zhang et al.   PLoS One

Brain-Derived Neurotrophic Factor Ameliorates Learning Deficits in a Rat Model of Alzheimer's Disease Induced by Aβ1-42

(2015) Lu Zhang et al.   PLoS One

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions

(2014) Jimena Baleriola et al.   CELL

Moderate Treadmill Exercise Protects Synaptic Plasticity of the Dentate Gyrus and Related Signaling Cascade in a Rat Model of Alzheimer’s Disease

(2014) An T. Dao et al.   MOLECULAR NEUROBIOLOGY

Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer’s disease

(2014) Natalia N. Nalivaeva et al.   Frontiers in Aging Neuroscience

Alzheimer’s disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs

(2014) Juan M. Zolezzi et al.   Frontiers in Aging Neuroscience

Treadmill Exercise Prevents Learning and Memory Impairment in Alzheimer’s Disease-Like Pathology

(2013) An T. Dao et al.   Current Alzheimer Research

Protective effect of pranlukast on Aβ 1–42-induced cognitive deficits associated with downregulation of cysteinyl leukotriene receptor 1

(2013) Su-Su Tang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Granulocyte colony stimulating factor (GCSF) improves memory and neurobehavior in an amyloid-β induced experimental model of Alzheimer's disease

(2013) Ajay Prakash et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition

(2012) Julie M. Bugg   ARCHIVES OF NEUROLOGY

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice

(2012) Masato Maesako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

(2012) B M Brown et al.   MOLECULAR PSYCHIATRY

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities

(2012) Abhay P. Sagare et al.   PHARMACOLOGY & THERAPEUTICS

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral metabolism after forced or voluntary physical exercise

(2011) Harish Kinni et al.   BRAIN RESEARCH

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer’s disease

(2011) Harshvardhan Rolyan et al.   JOURNAL OF NEURAL TRANSMISSION

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

The beneficial effects of regular exercise on cognition in REM sleep deprivation: Behavioral, electrophysiological and molecular evidence

(2011) Munder Zagaar et al.   NEUROBIOLOGY OF DISEASE

Exercise and Alzheimer's disease biomarkers in cognitively normal older adults

(2010) Kelvin Y. Liang et al.   ANNALS OF NEUROLOGY

Amyloid-β associated cortical thinning in clinically normal elderly

(2010) J. Alex Becker et al.   ANNALS OF NEUROLOGY

Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis

(2010) Asadollah Zarifkar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I

(2009) Yu-Fan Liu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease

(2009) Carla M. Yuede et al.   NEUROBIOLOGY OF DISEASE

Wheel-running in a transgenic mouse model of Alzheimer's disease: Protection or symptom?

(2008) Helene Richter et al.   BEHAVIOURAL BRAIN RESEARCH

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

 -Amyloid1-42 Induces Neuronal Death through the p75 Neurotrophin Receptor

(2008) A. Sotthibundhu et al.   JOURNAL OF NEUROSCIENCE

Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

(2008) A. Parachikova et al.   NEUROBIOLOGY OF DISEASE

Forced and voluntary exercise differentially affect brain and behavior

(2008) J.L. Leasure et al.   NEUROSCIENCE

Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states

(2007) Adrien W. Schmid et al.   BRAIN RESEARCH

Be smart, exercise your heart: exercise effects on brain and cognition

(2007) Charles H. Hillman et al.   NATURE REVIEWS NEUROSCIENCE