Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease

Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice

(2017) Mitsugu Yoneda et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions

(2017) Ake T. Lu et al.   Nature Communications

Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study

(2017) Marjo H. Eskelinen et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer's Disease Mice

(2017) Gary W. Arendash et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeine Exposure and the Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studiess

(2017) João Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

How does adenosine control neuronal dysfunction and neurodegeneration?

(2016) Rodrigo A. Cunha   JOURNAL OF NEUROCHEMISTRY

Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory

(2016) Ana Patrícia Simões et al.   NEUROPSYCHOPHARMACOLOGY

Meta-Analysis of the Association between Tea Intake and the Risk of Cognitive Disorders

(2016) Qing-Ping Ma et al.   PLoS One

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

(2016) Silvia Viana da Silva et al.   Nature Communications

Adenosine A2Areceptors are necessary and sufficient to trigger memory impairment in adult mice

(2015) N Pagnussat et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glucokinase regulatory protein

(2015) Anne Raimondo et al.   CURRENT OPINION IN LIPIDOLOGY

Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies

(2015) Giuseppe Grosso et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

(2015) P Li et al.   MOLECULAR PSYCHIATRY

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Caffeine acts through neuronal adenosine A2Areceptors to prevent mood and memory dysfunction triggered by chronic stress

(2015) Manuella P. Kaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What Doesn't Kill You ...

(2015) Mark P. Mattson   SCIENTIFIC AMERICAN

Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial

(2014) Daniela Mastroiacovo et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

(2014) C Laurent et al.   MOLECULAR PSYCHIATRY

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

(2014) M C Cornelis et al.   MOLECULAR PSYCHIATRY

Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology

(2014) Cyril Laurent et al.   NEUROBIOLOGY OF AGING

Effects of chocolate on cognitive function and mood: a systematic review

(2014) Andrew Scholey et al.   NUTRITION REVIEWS

Regulation of Fear Responses by Striatal and Extrastriatal Adenosine A2A Receptors in Forebrain

(2013) Catherine J. Wei et al.   BIOLOGICAL PSYCHIATRY

Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease

(2013) Hui Qi et al.   Geriatrics & Gerontology International

(−)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus

(2013) Ning Jia et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Acute caffeine administration impact on working memory-related brain activation and functional connectivity in the elderly: A BOLD and perfusion MRI study

(2013) S. Haller et al.   NEUROSCIENCE

Chocolate and the brain: Neurobiological impact of cocoa flavanols on cognition and behavior

(2013) Alexander N. Sokolov et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Effects of the adenosine A2A antagonist istradefylline on cognitive performance in rats with a 6-OHDA lesion in prefrontal cortex

(2013) Takako Kadowaki Horita et al.   PSYCHOPHARMACOLOGY

Caffeine in Floral Nectar Enhances a Pollinator's Memory of Reward

(2013) G. A. Wright et al.   SCIENCE

Coffee, Tea, and Cocoa and Risk of Stroke

(2013) Susanna C. Larsson   STROKE

Crude caffeine reduces memory impairment and amyloid β1–42 levels in an Alzheimer’s mouse model

(2012) Yi-Fang Chu et al.   FOOD CHEMISTRY

Benefits in Cognitive Function, Blood Pressure, and Insulin Resistance Through Cocoa Flavanol Consumption in Elderly Subjects With Mild Cognitive Impairment

(2012) Giovambattista Desideri et al.   HYPERTENSION

Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment

(2012) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation

(2012) V L Batalha et al.   MOLECULAR PSYCHIATRY

The effect of caffeine on working memory load-related brain activation in middle-aged males

(2012) Elissa B. Klaassen et al.   NEUROPHARMACOLOGY

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

(2012) Eric R Kandel   Molecular Brain

Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon ageing

(2011) Ana R. Costenla et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Astrocyte-Derived Adenosine and A1 Receptor Activity Contribute to Sleep Loss-Induced Deficits in Hippocampal Synaptic Plasticity and Memory in Mice

(2011) C. Florian et al.   JOURNAL OF NEUROSCIENCE

Selective inactivation of adenosine A2A receptors in striatal neurons enhances working memory and reversal learning

(2011) C. J. Wei et al.   LEARNING & MEMORY

Caffeine-induced synaptic potentiation in hippocampal CA2 neurons

(2011) Stephen B Simons et al.   NATURE NEUROSCIENCE

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Differential contributions of theobromine and caffeine on mood, psychomotor performance and blood pressure

(2011) E.S. Mitchell et al.   PHYSIOLOGY & BEHAVIOR

Enhancement of AMPA currents and GluR1 membrane expression through PKA-coupled adenosine A2A receptors

(2010) Raquel B. Dias et al.   HIPPOCAMPUS

Chronic Morphine Treatment Impaired Hippocampal Long-Term Potentiation and Spatial Memory via Accumulation of Extracellular Adenosine Acting on Adenosine A1 Receptors

(2010) G. Lu et al.   JOURNAL OF NEUROSCIENCE

Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease

(2010) K. Xu et al.   NEUROSCIENCE

RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory

(2010) S. E. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine

(2009) Jiang-Ning Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease

(2009) Mark P. Mattson   Annals of the New York Academy of Sciences

Regulation of cerebrospinal fluid production by caffeine consumption

(2009) Myoung-Eun Han et al.   BMC NEUROSCIENCE

Preferential enhancement of working memory in mice lacking adenosine A2A receptors

(2009) Sai-jun Zhou et al.   BRAIN RESEARCH

Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection

(2009) Ana M Sebastião et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stepwise Maturation of Apicobasal Polarity of the Neuroepithelium Is Essential for Vertebrate Neurulation

(2009) X. Yang et al.   JOURNAL OF NEUROSCIENCE

Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by  -Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

(2009) P. M. Canas et al.   JOURNAL OF NEUROSCIENCE

Regional differences in hippocampal calcium handling provide a cellular mechanism for limiting plasticity

(2009) S. B. Simons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caffeine Consumption and Cognitive Function at Age 70: The Lothian Birth Cohort 1936 Study

(2009) Janie Corley et al.   PSYCHOSOMATIC MEDICINE

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

RESEARCH ARTICLE: Up-regulation of Adenosine Receptors in the Frontal Cortex in Alzheimer's Disease

(2008) José L. Albasanz et al.   BRAIN PATHOLOGY

Caffeine, cognitive failures and health in a non-working community sample

(2008) Andrew P Smith   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Paraxanthine, the Primary Metabolite of Caffeine, Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels

(2008) S. Guerreiro et al.   MOLECULAR PHARMACOLOGY

Ligand-Dependent Oligomerization of Dopamine D2 and Adenosine A2A Receptors in Living Neuronal Cells

(2008) P.-A. Vidi et al.   MOLECULAR PHARMACOLOGY

Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses

(2008) Nelson Rebola et al.   NEURON

Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine

(2008) B.M. Fontinha et al.   NEUROPHARMACOLOGY

Adenosine A2A receptor blockade prevents memory dysfunction caused by β-amyloid peptides but not by scopolamine or MK-801

(2007) Geanne M.A. Cunha et al.   EXPERIMENTAL NEUROLOGY

Combined effects of smoking, coffee, and NSAIDs on Parkinson's disease risk

(2007) Karen M. Powers et al.   MOVEMENT DISORDERS

Does caffeine modulate verbal working memory processes? An fMRI study

(2007) F. Koppelstaetter et al.   NEUROIMAGE