Rolipram Attenuates Early Brain Injury Following Experimental Subarachnoid Hemorrhage in Rats: Possibly via Regulating the SIRT1/NF-κB Pathway

Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

(2017) Haiying Zhang et al.   Journal of Neuroinflammation

Improvement in cerebral ischemia–reperfusion injury through the TLR4/NF-κB pathway after Kudiezi injection in rats

(2017) Xuemei Liu et al.   LIFE SCIENCES

17β-Estradiol via SIRT1/Acetyl-p53/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication

(2017) Mehtab Khan et al.   MOLECULAR NEUROBIOLOGY

Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats

(2017) Dong-Quan Kou et al.   Pharmacological Reports

Histamine Regulates the Inflammatory Profile of SOD1-G93A Microglia and the Histaminergic System Is Dysregulated in Amyotrophic Lateral Sclerosis

(2017) Savina Apolloni et al.   Frontiers in Immunology

D4F alleviates macrophage-derived foam cell apoptosis by inhibiting the NF-κB-dependent Fas/FasL pathway

(2017) Hua Tian et al.   Scientific Reports

Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25–35 in rats

(2016) Yeye Zhuo et al.   METABOLIC BRAIN DISEASE

Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats

(2016) Jiang Wu et al.   STROKE

Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats

(2016) Xiang-Sheng Zhang et al.   Cell Death & Disease

Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling

(2015) Lei Zhao et al.   JOURNAL OF PINEAL RESEARCH

SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage

(2014) Xiao-Ming Zhou et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Amelioration of oxidative stress and protection against early brain injury by astaxanthin after experimental subarachnoid hemorrhage

(2014) Xiang-Sheng Zhang et al.   JOURNAL OF NEUROSURGERY

Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

(2014) Mark E. Gurney et al.   Neurotherapeutics

The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood–brain-barrier damage, inflammation and thrombosis

(2013) Peter Kraft et al.   EXPERIMENTAL NEUROLOGY

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphodiesterase Inhibition Rescues Chronic Cognitive Deficits Induced by Traumatic Brain Injury

(2013) D. J. Titus et al.   JOURNAL OF NEUROSCIENCE

Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage

(2013) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Sirt1 Promotes Axonogenesis by Deacetylation of Akt and Inactivation of GSK3

(2013) Xiao-hong Li et al.   MOLECULAR NEUROBIOLOGY

Activation of Nuclear Factor-κB in the Brain after Experimental Subarachnoid Hemorrhage and Its Potential Role in Delayed Brain Injury

(2013) Wan-Chun You et al.   PLoS One

Controversies and evolving new mechanisms in subarachnoid hemorrhage

(2013) Sheng Chen et al.   PROGRESS IN NEUROBIOLOGY

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

The importance of early brain injury after subarachnoid hemorrhage

(2012) Fatima A. Sehba et al.   PROGRESS IN NEUROBIOLOGY

The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats

(2011) Chuang Wang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling

(2011) Wenjing Guo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells

(2008) Christy A. Barlow et al.   APOPTOSIS

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model

(2007) Takashi Sugawara et al.   JOURNAL OF NEUROSCIENCE METHODS