Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of Selective PDE4D Negative Allosteric Modulators in the Object Retrieval Task in Female Cynomolgus Monkeys (Macaca fascicularis)

(2014) Jane S. Sutcliffe et al.   PLoS One

Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors

(2013) Taiji Goto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

(2013) William C. Kreisl et al.   BRAIN

Structural basis for the design of selective phosphodiesterase 4B inhibitors

(2013) David Fox et al.   CELLULAR SIGNALLING

Phosphodiesterase Inhibition Rescues Chronic Cognitive Deficits Induced by Traumatic Brain Injury

(2013) D. J. Titus et al.   JOURNAL OF NEUROSCIENCE

Monetary Costs of Dementia in the United States

(2013) Michael D. Hurd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exome Sequencing Identifies PDE4D Mutations in Acrodysostosis

(2012) Hane Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Exome Sequencing Identifies PDE4D Mutations as Another Cause of Acrodysostosis

(2012) Caroline Michot et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microgliain vitroand following CNS injury

(2012) Mousumi Ghosh et al.   GLIA

Identification of Novel Mutations ConfirmsPde4das a Major Gene Causing Acrodysostosis

(2012) Danielle C. Lynch et al.   HUMAN MUTATION

PRKAR1AandPDE4DMutations Cause Acrodysostosis but Two Distinct Syndromes with or without GPCR-Signaling Hormone Resistance

(2012) Agnès Linglart et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Phosphodiesterase isoform-specific expression induced by traumatic brain injury

(2012) Anthony A. Oliva et al.   JOURNAL OF NEUROCHEMISTRY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

(2011) O Bruno et al.   BRITISH JOURNAL OF PHARMACOLOGY

The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats

(2011) Chuang Wang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

(2010) F. Mori et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Type 4 Phosphodiesterase Plays Different Integrating Roles in Different Cellular Domains in Pyramidal Cortical Neurons

(2010) L. R. V. Castro et al.   JOURNAL OF NEUROSCIENCE

PKA Dynamics in a Drosophila Learning Center: Coincidence Detection by Rutabaga Adenylyl Cyclase and Spatial Regulation by Dunce Phosphodiesterase

(2010) Nicolas Gervasi et al.   NEURON

Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats

(2010) Yu-Fang Cheng et al.   PSYCHOPHARMACOLOGY

Discovery of selective PDE4B inhibitors

(2009) Kenji Naganuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Reversal of long-term dendritic spine alterations in Alzheimer disease models

(2009) D. L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease

(2008) Zena DeMarch et al.   NEUROBIOLOGY OF DISEASE

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

(2008) Olga A. H. Reneerkens et al.   PSYCHOPHARMACOLOGY