Translational models of prostate cancer bone metastasis

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

LuCaP Prostate Cancer Patient-Derived Xenografts Reflect the Molecular Heterogeneity of Advanced Disease an­­d Serve as Models for Evaluating Cancer Therapeutics

(2017) Holly M. Nguyen et al.   PROSTATE

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

(2017) Sheng Yu Ku et al.   SCIENCE

AKT in cancer: new molecular insights and advances in drug development

(2016) Prabhjot S. Mundi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Inherent and Tumor-Driven Immune Tolerance in the Prostate Microenvironment Impairs Natural Killer Cell Antitumor Activity

(2016) Christine Pasero et al.   CANCER RESEARCH

Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer

(2016) Maija P. Valta et al.   CLINICAL & EXPERIMENTAL METASTASIS

Targeted Agents in Preclinical and Early Clinical Development for the Treatment of Cancer Bone Metastases

(2016) Toru Hiraga   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Discovery and bio-optimization of human antibody therapeutics using the XenoMouse®transgenic mouse platform

(2016) Ian N. Foltz et al.   IMMUNOLOGICAL REVIEWS

Real-Time GFP Intravital Imaging of the Differences in Cellular and Angiogenic Behavior of Subcutaneous and Orthotopic Nude-Mouse Models of Human PC-3 Prostate Cancer

(2016) Yong Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models

(2015) Giovanni Luca Gravina et al.   BMC CANCER

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Overexpression of FGF9 in Prostate Epithelial Cells Augments Reactive Stroma Formation and Promotes Prostate Cancer Progression

(2015) Yanqing Huang et al.   International Journal of Biological Sciences

The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer

(2015) Ning Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Bone metastasis and the metastatic niche

(2015) Guangwen Ren et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Glial Cell Line-Derived Neurotrophic Factor Induces Cell Proliferation in the Mouse Urogenital Sinus

(2015) Hyun-Jung Park et al.   MOLECULAR ENDOCRINOLOGY

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

(2015) Matthew T Chang et al.   NATURE BIOTECHNOLOGY

CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models

(2015) Giovanni Luca Gravina et al.   PROSTATE

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche

(2015) Michelle A. Lawson et al.   Nature Communications

Human tumor infiltrating lymphocytes cooperatively regulate prostate tumor growth in a humanized mouse model

(2015) Michael D Roth et al.   Journal for ImmunoTherapy of Cancer

An In Vivo Mouse Model for Human Prostate Cancer Metastasis

(2015) Aaron M. Havens et al.   NEOPLASIA

GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche

(2015) Yusuke Shiozawa et al.   NEOPLASIA

Prevalence of Prostate Cancer Metastases after Intravenous Inoculation Provides Clues into the Molecular Basis of Dormancy in the Bone Marrow Microenvironment

(2015) Younghun Jung et al.   NEOPLASIA

Next generation patient-derived prostate cancer xenograft models

(2014) Yuzhuo Wang et al.   ASIAN JOURNAL OF ANDROLOGY

A reconstructed metastasis model to recapitulate the metastatic spread in vitro

(2014) Mukti R. Parikh et al.   Biotechnology Journal

Molecular characterization of exosome-like vesicles from breast cancer cells

(2014) Stefan Kruger et al.   BMC CANCER

An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer

(2014) Song Xu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone

(2014) Parisa Hesami et al.   CLINICAL & EXPERIMENTAL METASTASIS

Bone-induced c-kit expression in prostate cancer: A driver of intraosseous tumor growth

(2014) Leandro E. Mainetti et al.   INTERNATIONAL JOURNAL OF CANCER

PCSD1, a new patient-derived model of bone metastatic prostate cancer, is castrate-resistant in the bone-niche

(2014) Elana Godebu et al.   Journal of Translational Medicine

Secretome Analysis of an Osteogenic Prostate Tumor Identifies Complex Signaling Networks Mediating Cross-talk of Cancer and Stromal Cells Within the Tumor Microenvironment

(2014) Yu-Chen Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Annexin 2–CXCL12 Interactions Regulate Metastatic Cell Targeting and Growth in the Bone Marrow

(2014) Younghun Jung et al.   MOLECULAR CANCER RESEARCH

Hydrogel-Based 3D Model of Patient-Derived Prostate Xenograft Tumors Suitable for Drug Screening

(2014) Eliza L. S. Fong et al.   MOLECULAR PHARMACEUTICS

RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation

(2014) Woosook Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypernociceptive responses following the intratibial inoculation of RM1 prostate cancer cells in mice

(2014) María Llorián-Salvador et al.   PROSTATE

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Prostate cancer metastases alter bone mineral and matrix composition independent of effects on bone architecture in mice — A quantitative study using microCT and Raman spectroscopy

(2013) Xiaohong Bi et al.   BONE

Human fucosyltransferase 6 enables prostate cancer metastasis to bone

(2013) J Li et al.   BRITISH JOURNAL OF CANCER

A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer

(2013) Emmanuel S. Antonarakis et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

(2013) D. Lin et al.   CANCER RESEARCH

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

HEF1 promotes epithelial mesenchymal transition and bone invasion in prostate cancer under the regulation of microRNA-145

(2013) Wei Guo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Docetaxel and dasatinib or placebo in men with metastatic castration-resistant prostate cancer (READY): a randomised, double-blind phase 3 trial

(2013) John C Araujo et al.   LANCET ONCOLOGY

SPARCL1 suppresses metastasis in prostate cancer

(2013) Yuzhu Xiang et al.   Molecular Oncology

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Multiple metastases in a novel LNCaP model of human prostate cancer

(2013) MINHONG ZOU et al.   ONCOLOGY REPORTS

GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation

(2013) Russell S. Taichman et al.   PLoS One

Correction: Changes in Soil Carbon and Nitrogen following Land Abandonment of Farmland on the Loess Plateau, China

(2013) Lei Deng et al.   PLoS One

Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases

(2012) Zhihu Ding et al.   CELL

SnapShot: Bone Metastasis

(2012) Brian Ell et al.   CELL

Integrin alpha2beta1 (α2β1) promotes prostate cancer skeletal metastasis

(2012) Joseph L. Sottnik et al.   CLINICAL & EXPERIMENTAL METASTASIS

A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions

(2012) Omer Raheem et al.   Journal of Translational Medicine

Non-invasive MicroCT Imaging Characterization and In Vivo Targeting of BB2 Receptor Expression of a PC-3 Bone Metastasis Model

(2012) Christopher T. Winkelmann et al.   MOLECULAR IMAGING AND BIOLOGY

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

(2012) Ingrid G Winkler et al.   NATURE MEDICINE

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome

(2012) P. J. Hurley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of Snail in prostate cancer

(2012) Bethany N. Smith et al.   Cell Adhesion & Migration

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

(2011) Yusuke Shiozawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Evaluating the effects of mixed osteolytic/osteoblastic metastasis on vertebral bone quality in a new rat model

(2011) Lisa Wise-Milestone et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial

(2011) Matthew R Smith et al.   LANCET

c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer

(2011) J L Regan et al.   ONCOGENE

PC3 is a cell line characteristic of prostatic small cell carcinoma

(2011) Sheng Tai et al.   PROSTATE

Biochemical and molecular mechanisms of action of bisphosphonates

(2010) Michael J. Rogers et al.   BONE

Modeling prostate cancer: a perspective on transgenic mouse models

(2010) Varinder Jeet et al.   CANCER AND METASTASIS REVIEWS

Inhibitory effects of megakaryocytic cells in prostate cancer skeletal metastasis

(2010) Xin Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

SKI-606 (Bosutinib) Blocks Prostate Cancer Invasion, Growth, and Metastasis In vitro and In vivo through Regulation of Genes Involved in Cancer Growth and Skeletal Metastasis

(2010) S. A. Rabbani et al.   MOLECULAR CANCER THERAPEUTICS

Effect of the Specific Src Family Kinase Inhibitor Saracatinib on Osteolytic Lesions Using the PC-3 Bone Model

(2010) J. C. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Basal epithelial stem cells are efficient targets for prostate cancer initiation

(2010) D. A. Lawson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases

(2010) Nanda K. Thudi et al.   PROSTATE

Dasatinib inhibits the growth of prostate cancer in bone and provides additional protection from osteolysis

(2009) T Koreckij et al.   BRITISH JOURNAL OF CANCER

Anti-metastatic effects of liposomal gemcitabine in a human orthotopic LNCaP prostate cancer xenograft model

(2009) Peter Jantscheff et al.   CLINICAL & EXPERIMENTAL METASTASIS

Phase II Study of Dasatinib in Patients with Metastatic Castration-Resistant Prostate Cancer

(2009) E. Y. Yu et al.   CLINICAL CANCER RESEARCH

Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials

(2009) David P Dearnaley et al.   LANCET ONCOLOGY

Bisphosphonates: Mechanism of Action and Role in Clinical Practice

(2009) Matthew T. Drake et al.   MAYO CLINIC PROCEEDINGS

Denosumab in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer

(2009) Matthew R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel model of bone-metastatic prostate cancer in immunocompetent Mice

(2009) Carl A. Power et al.   PROSTATE

Molecular mechanisms of metastasis in prostate cancer

(2008) Noel W. Clarke et al.   ASIAN JOURNAL OF ANDROLOGY

Alendronate decreases orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice

(2008) Johanna M Tuomela et al.   BMC CANCER

Influence of simultaneous targeting of the bone morphogenetic protein pathway and RANK/RANKL axis in osteolytic prostate cancer lesion in bone

(2008) Mandeep S. Virk et al.   BONE

Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine

(2008) A C Dudley et al.   BRITISH JOURNAL OF CANCER

Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

(2008) S.-Y. Sung et al.   CANCER RESEARCH

Loss of BRCA2 promotes prostate cancer cell invasion through up-regulation of matrix metalloproteinase-9

(2008) Loredana Moro et al.   CANCER SCIENCE

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

Intraosseous injection of RM1 murine prostate cancer cells promotes rapid osteolysis and periosteal bone deposition

(2008) N. Patrick McCabe et al.   CLINICAL & EXPERIMENTAL METASTASIS

Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model

(2008) Haiyen E. Zhau et al.   CLINICAL & EXPERIMENTAL METASTASIS

Suppression of Wnt/β-catenin signaling inhibits prostate cancer cell proliferation

(2008) Wenyan Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

FGF-8 is involved in bone metastasis of prostate cancer

(2008) Maija P. Valta et al.   INTERNATIONAL JOURNAL OF CANCER

Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock-In Mice That Express Chimeric (Murine/Human) RANKL*

(2008) Paul J Kostenuik et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Histopathological Assessment of Prostate Cancer Bone Osteoblastic Metastases

(2008) Martine P. Roudier et al.   JOURNAL OF UROLOGY

Cadherin-11 Promotes the Metastasis of Prostate Cancer Cells to Bone

(2008) K. Chu et al.   MOLECULAR CANCER RESEARCH

RANK ligand inhibition plus docetaxel improves survival and reduces tumor burden in a murine model of prostate cancer bone metastasis

(2008) R. E. Miller et al.   MOLECULAR CANCER THERAPEUTICS

Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis

(2008) Christopher L. Hall et al.   PROSTATE

RANKL inhibition is an effective adjuvant for docetaxel in a prostate cancer bone metastases model

(2008) K. M. Woods Ignatoski et al.   PROSTATE

Zoledronic acid decreased osteolysis but not bone metastasis in a nude mouse model of canine prostate cancer with mixed bone lesions

(2008) Nanda K. Thudi et al.   PROSTATE