Article
Biochemistry & Molecular Biology
Michele Iuliani, Sonia Simonetti, Giulia Ribelli, Andrea Napolitano, Umile Giuseppe Longo, Bruno Vincenzi, Paolo Orsaria, Vincenzo Denaro, Giuseppe Tonini, Daniele Santini, Pantano Francesco
Summary: This study compared the potential effects of three CDK4/6 inhibitors on the breast cancer bone microenvironment. The results showed that these inhibitors exerted similar inhibitory effects on the differentiation of bone resorption cells and the expression of bone resorption markers, without affecting cell viability. However, they did not affect the ability of bone formation cells to produce bone matrix, although higher doses of two inhibitors reduced the viability of these cells. In co-culture models of breast cancer and bone cells, palbociclib demonstrated a lower anti-tumor effect compared to the other two inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Gemma Di Pompo, Costantino Errani, Robert Gillies, Laura Mercatali, Toni Ibrahim, Jacopo Tamanti, Nicola Baldini, Sofia Avnet
Summary: The study suggests that tumor-derived acidosis plays a role in promoting excessive osteolysis in bone metastasis by inducing an inflammatory phenotype in osteoblasts, which can be treated by targeting IL-6 or IL-8.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yongguang Gao, Suryaji Patil, Jingxian Jia
Summary: Osteoporosis is a major bone disorder affecting both men and women, primarily due to an imbalance in bone remodeling. Understanding the effects of molecules produced by different cells on bone can help identify new therapeutic targets and approaches for preventing and treating bone disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Rongchen Dai, Mengfan Liu, Xincheng Xiang, Zhichao Xi, Hongxi Xu
Summary: Bone metastasis occurs when tumor cells enter the circulation and colonize sites in the bone. Dormant tumor cells in the bone marrow are regulated by osteoclasts and osteoblasts. Understanding the roles of these cells in tumor dormancy can provide new insights for preventing and treating bone metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Nikolaos Giannakoulas, Ioannis Ntanasis-Stathopoulos, Evangelos Terpos
Summary: Significant progress has been made in developing therapies for multiple myeloma, but it remains incurable. Research has shed light on the genetic background of malignant plasma cells and the crucial role of the bone marrow microenvironment. The interaction between myeloma cells and components of the microenvironment is considered essential in the pathogenesis of multiple myeloma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jie Xu, Linxin Yu, Feng Liu, Longbiao Wan, Zhenhua Deng
Summary: The complicated connections and cross talk between the skeletal system and the immune system are developing into the field of Osteoimmunology. Cytokines, such as TNF, IL, IFN, and chemokines, play a critical role in bone remodeling, particularly in the pathogenesis and development of osteoporosis. This review summarizes the effects of cytokines on osteoblasts and osteoclasts, offering a reference for the role of immunology in osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Wenbo Zhao, Philip Wiedemann, Eva Maria Woelfel, Mona Neven, Stephanie Peters, Thomas Imhof, Manuel Koch, Bjoern Busse, Michael Amling, Thorsten Schinke, Timur Alexander Yorgan
Summary: Col22a1, predominantly expressed in bone, deficiency may result in trabecular osteopenia and increased osteoclast numbers.
Review
Pharmacology & Pharmacy
Kok-Yong Chin, Sophia Ogechi Ekeuku, Anne Trias
Summary: Nitrogen-containing bisphosphonates cause BRONJ by inhibiting bone resorption, but GGOH shows promise in managing BRONJ, pending further research and clinical trials for validation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Jolene Helena, Anna Joubert, Peace Mabeta, Magdalena Coetzee, Roy Lakier, Anne Mercier
Summary: In this study, the potential radiosensitizing effects of ESE-16 were investigated in an in vitro bone metastasis model. The results showed increased cytotoxicity in tumor and endothelial cells, with spared bone cells. Tumor cells displayed increased mitotic indices, DNA damage with impaired repair, and reduced metastatic signaling.
Review
Physiology
Scott Epsley, Samuel Tadros, Alexander Farid, Daniel Kargilis, Sameer Mehta, Chamith S. Rajapakse
Summary: Bone remodeling is a continual process involving osteoblasts and osteoclasts, where inflammation plays a crucial role in skewing the process towards resorption. Inflammatory mediators interact with bone cells to alter the expression of regulatory factors, leading to various bone-related pathologies. Further research is needed to advance early detection and treatments for bone diseases influenced by inflammation.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Saravanan Sekaran, Anitha Roy, Lakshmi Thangavelu
Summary: Bone disorders are a global concern, and flavonoids, with their multi-faceted biological activities, play a significant role in maintaining bone health.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Barbara Kolodziejska, Natalia Stepien, Joanna Kolmas
Summary: This study summarizes the role of strontium in the treatment of osteoporosis, highlighting its multidirectional effects on bone tissue and its similarities to calcium. It discusses the unique mechanism of action of strontium ranelate and the increasing interest in using strontium ions in ceramics as bone replacement materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jesus Delgado-Calle, Kevin McAndrews, Gerald Wu, Ashley L. Orr, Adam Ferrari, Xiaolin Tu, Venkatesan Srinivasan, G. David Roodman, Frank H. Ebetino, Robert K. Boeckman, Teresita Bellido
Summary: This study reveals that PTH signaling upregulates Notch pathway components, and Notch activation contributes to the catabolic actions of PTH in bone. Deleting the PTH receptor or overexpressing sclerostin in osteocytes abolishes the increase in Notch components caused by PTH. Moreover, bone-targeted Notch inhibition enhances the bone anabolic effects of intermittent PTH.
Review
Cell Biology
Anna Ruocco, Anna Sirico, Rubina Novelli, Silvia Iannelli, Shane Vontelin Van Breda, Diego Kyburz, Paul Hasler, Andrea Aramini, Pier Giorgio Amendola
Summary: Bone remodeling is a dynamic process dependent on the functions of osteoblasts and osteoclasts. The complement system plays a crucial role in regulating the functions of these cells, particularly in inflammatory states. This review analyzes the role of the C5a-C5aR1 axis in bone physiology and pathophysiology, including its involvement in inflammatory bone diseases such as rheumatoid arthritis, osteoporosis and bone cancer metastasis. Furthermore, pharmacological approaches targeting C5aR1 for the treatment of these conditions are examined. The article highlights the importance of the C5a-C5aR1 axis as a therapeutic target for mediating interactions between the skeletal and immune systems, considering the growing interest in osteoimmunology and the lack of data on its role in bone pathophysiology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chen Chen, Ya-Mei Liu, Bin-Lan Fu, Liang-Liang Xu, Bin Wang
Summary: MiRNAs are small regulatory RNA molecules that play important roles in gene expression, with miR-21 in particular having significant effects in orthopedic diseases by influencing osteoblasts, osteoclasts, and the occurrence, development, treatment, and prevention of bone diseases through various mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)