Review
Immunology
Seung-Jin Kim, Dipendra Khadka, Jae Ho Seo
Summary: This article discusses the process of tumors adapting to adverse environments through communication with neighboring cells. Understanding the physiology of these tumors and their interaction with the tumor environment can help in developing promising tumor treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Summary: Mechanical features of cancer cells play a crucial role in tumor development and progression, with mechanosensory proteins potentially mediating oncogenic signaling and response to chemotherapy. Studying changes in tumor microenvironment and matrix rigidity can offer new anti-cancer strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Eiman Elwakeel, Andreas Weigert
Summary: Activation of the tumor-associated stroma and the role of cancer-associated fibroblasts (CAFs) in shaping tumor development are crucial in breast cancer. Understanding the multiple functions of CAFs and developing intervention strategies are important for improving breast cancer therapy. Further research is needed to identify specific subsets of CAFs that can be targeted for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
RamaRao Malla, Kiran Puvalachetty, Rahul K. Vempati, Rakshmitha Marni, Neha Merchant, Ganji Purnachandra Nagaraju
Summary: The interplay between cancer stem cells, exosomes, and circulatory tumor cells in breast cancer has been discussed. They communicate with stromal and immune cells to promote metastasis and induce epithelial mesenchymal transition (EMT) involved in metastasis.
CLINICAL BREAST CANCER
(2022)
Review
Oncology
Yi Li, Changyuan Wang, Ting Huang, Xijie Yu, Bole Tian
Summary: Breast cancer deaths are primarily caused by metastasis. There are several treatment options, but limited options for preventing or inhibiting breast tumor metastases. Studies have focused on the importance of the tumor microenvironment (TME) in metastasis of breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Kellen Wright, Thuc Ly, Matthew Kriet, Andras Czirok, Sufi Mary Thomas
Summary: Cancer cells rely on the tumor microenvironment (TME) for growth and metastasis. Among the components of TME, cancer-associated fibroblasts (CAFs) play a crucial role. CAFs are heterogeneous and can remodel the microenvironment, as well as communicate with immune cells to aid in immune evasion. This review focuses on the factors and signaling pathways of CAFs.
Article
Biology
Samantha C. Schwager, Katherine M. Young, Lauren A. Hapach, Caroline M. Carlson, Jenna A. Mosier, Tanner J. McArdle, Wenjun Wang, Curtis Schunk, Anissa L. Jayathilake, Madison E. Bates, Francois Bordeleau, Marc A. Antonyak, Richard A. Cerione, Cynthia A. Reinhart-King
Summary: Weakly migratory cancer cells disseminate from the primary tumor via communication with stromal cells and enhance cancer cell migration and metastasis by releasing microvesicles rich in Tg2.
Review
Engineering, Biomedical
Jyothsna Vasudevan, Kuan Jiang, Javier. G. Fernandez, Chwee Teck Lim
Summary: The extracellular matrix (ECM) plays a crucial role in the modulation of tumor progression by chemically stimulating tumor cells and offering physical support. The translation between matrix biophysical cues and intracellular signaling has led to rapid growth in cancer mechanobiology. Efforts have been made to develop in vitro tumor mimicking platforms to visualize and quantify mechanical forces within the tissue and understand their impact on tumor cell behavior. Perturbations in these cues can alter cellular mechanisms of mechanotransduction, enhancing malignancy. Engineering techniques can be used to emulate the mechanical properties of tumors and aid in the development of ECM-targeted therapeutics.
ACTA BIOMATERIALIA
(2023)
Article
Oncology
Amira F. Mahdi, Joanne Nolan, Ruth i. O'Connor, Aoife J. Lowery, Joanna M. Allardyce, Patrick A. Kiely, Kieran McGourty
Summary: The extracellular matrix (ECM) plays a significant role in the development and progression of breast cancer, and Annexin A2 has been identified as a key protein in this process. This study demonstrates that the presence of collagen-I in the ECM leads to the phosphorylation and translocation of Annexin A2, and identifies fibronectin as a novel interactor of Annexin A2. Furthermore, reducing Annexin A2 expression decreases the degradation of fibronectin by cancer cells, with this effect being influenced by collagen-I levels.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Arkadiusz Lepucki, Kinga Orlinska, Aleksandra Mielczarek-Palacz, Jacek Kabut, Pawel Olczyk, Katarzyna Komosinska-Vassev
Summary: The extracellular matrix is a dynamic molecular network composed of various molecules that play a critical role in regulating cell-cell and cell-matrix interactions, influencing cell growth, migration, and differentiation, as well as serving as a reservoir for cytokines and growth factors. The breakdown of normal ECM and its replacement with tumor ECM is a key driver for tumorigenesis and metastasis, affecting the composition of the tumor microenvironment and promoting malignant progression. Abnormal ECM also affects stromal cells, tumor-associated angiogenesis, inflammation, and the immune response. Understanding the role of ECM in breast cancer can help identify disease markers and therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Arianna Parnigoni, Paola Moretto, Manuela Viola, Evgenia Karousou, Alberto Passi, Davide Vigetti
Summary: Breast cancer is the most common neoplasm in women, and its lethality is mainly due to the ability of tumor cells to invade and seed distant organs. Hormone receptors play a critical role in determining tumor aggressiveness and targeted therapies, but the role of the tumor microenvironment is also evident. This article focuses on the role of the extracellular matrix polysaccharide hyaluronan in relation to hormone receptor expression in breast cancer cells.
Review
Biochemistry & Molecular Biology
Misung Park, Dohee Kim, Sunghyub Ko, Ayoung Kim, Kyumin Mo, Hyunho Yoon
Summary: Breast cancer is the most common malignancy in women worldwide, and metastasis is the leading cause of high mortality. Currently, breast cancer is often discovered or diagnosed after metastasis has occurred, resulting in poor prognosis. Understanding the mechanisms and nature of breast cancer metastasis can facilitate the development of targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Devadarssen Murdamoothoo, Zhen Sun, Alev Yilmaz, Gilles Riegel, Cherine Abou-Faycal, Claire Deligne, Ines Velazquez-Quesada, William Erne, Marine Nascimento, Matthias Morgelin, Gerard Cremel, Nicodeme Paul, Raphael Carapito, Romain Veber, Helene Dumortier, Jingping Yuan, Kim S. Midwood, Thomas Loustau, Gertraud Orend
Summary: The study found that tenascin-C inhibits CD8 T cell infiltration by inducing CXCL12, which may contribute to the low response rates of immune checkpoint therapy in cancer treatment. Blocking the CXCR4 receptor of CXCL12 enhances macrophage and CD8 T cell infiltration, reducing tumor growth and metastasis.
EMBO MOLECULAR MEDICINE
(2021)
Article
Immunology
Yan Zhou, Qi Tian, Huan Gao, Lizhe Zhu, Ying Zhang, Chenchen Zhang, Jiao Yang, Bo Wang
Summary: The breast cancer samples were classified into T-H-activated and TH-silenced clusters based on gene signatures, with the T-H-activated cluster showing better 10-year overall survival. The study explored the relationship between TH cell subtypes and ECM in breast cancer, highlighting the importance of understanding the crosstalk between ECM and T-H cell subtypes for prognosis and treatment response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Meimei Wu, Yanfang Liang, Xin Zhang
Summary: Breast cancer is the most common malignant disease worldwide, and distant metastasis is the leading cause of death. The lung is a common site for breast cancer metastasis and the alterations in the pulmonary microenvironment play a crucial role in this process.
FRONTIERS IN ONCOLOGY
(2022)