Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

(2015) Jae Kyu Ryu et al.   Nature Communications

Effects of Glatiramer Acetate in a Spontaneous Model of Autoimmune Neuroinflammation

(2014) Stefan Bittner et al.   AMERICAN JOURNAL OF PATHOLOGY

Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity

(2014) Johanna Breuer et al.   ANNALS OF NEUROLOGY

Human CD4+HLA-G+ regulatory T cells are potent suppressors of graft-versus-host disease in vivo

(2014) Susann Pankratz et al.   FASEB JOURNAL

Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS

(2013) Stefan Bittner et al.   NATURE MEDICINE

CD4+NKG2D+ T Cells Exhibit Enhanced Migratory and Encephalitogenic Properties in Neuroinflammation

(2013) Tobias Ruck et al.   PLoS One

Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin

(2013) Ioannis Mitroulis et al.   THROMBOSIS AND HAEMOSTASIS

In vivo roles of factor XII

(2012) T. Renne et al.   BLOOD

Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation

(2012) F. Langhauser et al.   BLOOD

Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2012) Harald F. Langer et al.   CIRCULATION RESEARCH

Next-Generation Antithrombotics in Ischemic Stroke: Preclinical Perspective on ‘Bleeding-Free Antithrombosis’

(2012) Peter Kraft et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells

(2012) Michael G Strainic et al.   NATURE IMMUNOLOGY

Ischemic stroke and traumatic brain injury: The role of the kallikrein–kinin system

(2012) Christiane Albert-Weißenberger et al.   PROGRESS IN NEUROBIOLOGY

Regulatory mechanisms of the plasma contact system

(2012) Coen Maas et al.   THROMBOSIS RESEARCH

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

(2011) Chris H. Polman et al.   ANNALS OF NEUROLOGY

Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking

(2011) Kerstin Göbel et al.   JOURNAL OF AUTOIMMUNITY

Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet

(2011) Petra D Cravens et al.   Journal of Neuroinflammation

In Vivo Induction of Tr1 Cells via Mucosal Dendritic Cells and AHR Signaling

(2011) Henry Yim Wu et al.   PLoS One

Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis

(2010) G. A. LaRusch et al.   BLOOD

Factor XIIa Inhibitor Recombinant Human Albumin Infestin-4 Abolishes Occlusive Arterial Thrombus Formation Without Affecting Bleeding

(2010) Ina Hagedorn et al.   CIRCULATION

Thrombin receptors and their antagonists: an update on the patent literature

(2010) Giuseppe Cirino et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system

(2009) Ulf Schulze-Topphoff et al.   NATURE MEDICINE

Innate and Adaptive Autoimmunity Directed to the Central Nervous System

(2009) Roopa Bhat et al.   NEURON

Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation

(2008) K. Li et al.   BLOOD

B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: Implications for the lesion pathogenesis of multiple sclerosis

(2008) Sonja Ortler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A rush to judgment on Th17: Figure 1.

(2008) Lawrence Steinman   JOURNAL OF EXPERIMENTAL MEDICINE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system

(2007) Alvin H. Schmaier   INTERNATIONAL IMMUNOPHARMACOLOGY