Breaking boundaries—coagulation and fibrinolysis at the neurovascular interface

Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death

(2015) Gerard ILL-Raga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Coagulation takes center stage in inflammation

(2015) K. Akassoglou   BLOOD

Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration

(2015) Marta Cortes-Canteli et al.   NEUROBIOLOGY OF AGING

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Activation of the factor XII-driven contact system in Alzheimer’s disease patient and mouse model plasma

(2015) Daria Zamolodchikov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

(2015) Jae Kyu Ryu et al.   Nature Communications

Plasminogen activator inhibitor-1 as an early potential diagnostic marker for Alzheimer's disease

(2014) Jaeho Oh et al.   EXPERIMENTAL GERONTOLOGY

A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice

(2014) Hyung Jin Ahn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmin deficiency leads to fibrin accumulation and a compromised inflammatory response in the mouse brain

(2014) K. Hultman et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Update on Intravenous Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke

(2014) Jennifer E. Fugate et al.   MAYO CLINIC PROCEEDINGS

Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis

(2014) Norah G. Verbout et al.   METABOLIC BRAIN DISEASE

Proteomic Profiling in Multiple Sclerosis Clinical Courses Reveals Potential Biomarkers of Neurodegeneration

(2014) Maria Liguori et al.   PLoS One

From Fibrinolysis to the Plasminogen–Plasmin System and Beyond: A Remarkable Growth of Knowledge, with Personal Observations on the History of Fibrinolysis

(2014) Hau Kwaan   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Early detection of thrombin activity in neuroinflammatory disease

(2013) Dimitrios Davalos et al.   ANNALS OF NEUROLOGY

The APOE ε4/ε4 Genotype Potentiates Vascular Fibrin(Ogen) Deposition in Amyloid-Laden Vessels in the Brains of Alzheimer's Disease Patients

(2013) Karin Hultman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease

(2013) Z. Tucsek et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Tissue plasminogen activator arrests Alzheimer's disease pathogenesis

(2013) Shin Bi Oh et al.   NEUROBIOLOGY OF AGING

Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications

(2013) E. Cristante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Metalloproteinases and Blood-Brain Barrier Disruption in Acute Ischemic Stroke

(2013) Shaheen E. Lakhan et al.   Frontiers in Neurology

t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes

(2012) B. Niego et al.   BLOOD

A  delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin

(2012) D. Zamolodchikov et al.   BLOOD

Neuropathology of the blood–brain barrier and pharmaco-resistance in human epilepsy

(2012) Joan Y. W. Liu et al.   BRAIN

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Thrombin induces an inflammatory phenotype in a human brain endothelial cell line

(2012) Leah M. Alabanza et al.   JOURNAL OF NEUROIMMUNOLOGY

Thrombin Activity Associated with Neuronal Damage during Acute Focal Ischemia

(2012) B. Chen et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E Sets the Stage: Response to Injury Triggers Neuropathology

(2012) Robert W. Mahley et al.   NEURON

Vorapaxar in the Secondary Prevention of Atherothrombotic Events

(2012) David A. Morrow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Evolution of the blood-brain barrier in newly forming multiple sclerosis lesions

(2011) María I. Gaitán et al.   ANNALS OF NEUROLOGY

Fibrinogen alters mouse brain endothelial cell layer integrity affecting vascular endothelial cadherin

(2011) Nino Muradashvili et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A High Affinity Interaction of Plasminogen with Fibrin Is Not Essential for Efficient Activation by Tissue-type Plasminogen Activator

(2011) Paul Y. Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of Tissue Plasminogen Activator on the Neurovascular Unit: From Clinical Data to Experimental Evidence

(2011) Denis Vivien et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Quantitative MRI Reveals the Elderly Ischemic Brain is Susceptible to Increased Early Blood—Brain Barrier Permeability Following Tissue Plasminogen Activator Related to Claudin 5 and Occludin Disassembly

(2011) Jaspreet Kaur et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

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(2011) Carla Jennewein et al.   MOLECULAR MEDICINE

Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort

(2011) Andrew P. Viggars et al.   NEUROSCIENCE LETTERS

Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis

(2011) Rebecca Craig-Schapiro et al.   PLoS One

Fibrinogen as a key regulator of inflammation in disease

(2011) Dimitrios Davalos et al.   Seminars in Immunopathology

Fibrinogen Depleting Agent Batroxobin has a Beneficial Effect on Experimental Autoimmune Encephalomyelitis

(2010) Yang Yang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-  after Vascular Damage

(2010) C. Schachtrup et al.   JOURNAL OF NEUROSCIENCE

Autocrine and paracrine up-regulation of blood–brain barrier function by plasminogen activator inhibitor-1

(2010) Shinya Dohgu et al.   MICROVASCULAR RESEARCH

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

(2010) Dan Shlosberg et al.   Nature Reviews Neurology

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

Blood–brain barrier permeability and tPA-mediated neurotoxicity

(2010) Rami Abu Fanne et al.   NEUROPHARMACOLOGY

Alzheimer's disease peptide  -amyloid interacts with fibrinogen and induces its oligomerization

(2010) H. J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-brain barrier breakdown and repair by Src after thrombin-induced injury

(2009) Da-Zhi Liu et al.   ANNALS OF NEUROLOGY

Plasmin-Mediated Degradation of Laminin γ-1 Is Critical for Ethanol-Induced Neurodegeneration

(2009) Anna E. Skrzypiec et al.   BIOLOGICAL PSYCHIATRY

A T cell-binding fragment of fibrinogen can prevent autoimmunity

(2009) Yoshikazu Takada et al.   JOURNAL OF AUTOIMMUNITY

Fibrinogen induces alterations of endothelial cell tight junction proteins

(2009) Phani K. Patibandla et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Fibrinogen signal transduction in the nervous system

(2009) J. K. RYU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

(2008) Svetlana Stamatovic et al.   Current Neuropharmacology

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Coagulation status and biochemical and inflammatory markers in multiple sclerosis

(2008) Fehime B. Aksungar et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

(2008) Enming J Su et al.   NATURE MEDICINE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Chronic relapsing experimental allergic encephalomyelitis (CREAE) in plasminogen activator inhibitor-1 knockout mice: the effect of fibrinolysis during neuroinflammation

(2007) E. East et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY