Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

A Variable Active Site Residue Influences the Kinetics of Response Regulator Phosphorylation and Dephosphorylation

(2016) Robert M. Immormino et al.   BIOCHEMISTRY

Experimental Analysis of Functional Variation within Protein Families: Receiver Domain Autodephosphorylation Kinetics

(2016) Stephani C. Page et al.   JOURNAL OF BACTERIOLOGY

Molecular Mechanisms of Two-Component Signal Transduction

(2016) Christopher P. Zschiedrich et al.   JOURNAL OF MOLECULAR BIOLOGY

A Dual-Sensing Receptor Confers Robust Cellular Homeostasis

(2016) Hannah Schramke et al.   Cell Reports

Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking

(2016) B. N. Dubey et al.   Science Advances

Imidazole as a Small Molecule Analogue in Two-Component Signal Transduction

(2015) Stephani C. Page et al.   BIOCHEMISTRY

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

A coiled coil switch mediates cold sensing by the thermosensory protein DesK

(2015) Emilio Saita et al.   MOLECULAR MICROBIOLOGY

The Pfam protein families database: towards a more sustainable future

(2015) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen

(2015) Jonathan W. Willett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pervasive degeneracy and epistasis in a protein-protein interface

(2015) A. I. Podgornaia et al.   SCIENCE

Signal Transduction in Histidine Kinases: Insights from New Structures

(2015) Manasi P. Bhate et al.   STRUCTURE

Temperature Sensing by Membranes

(2014) Diego de Mendoza   Annual Review of Microbiology

Allosteric Activation of Bacterial Response Regulators: the Role of the Cognate Histidine Kinase Beyond Phosphorylation

(2014) Felipe Trajtenberg et al.   mBio

Visualizing autophosphorylation in histidine kinases

(2014) Patricia Casino et al.   Nature Communications

Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation

(2014) Ariel E. Mechaly et al.   PLOS BIOLOGY

Nonconserved Active Site Residues Modulate CheY Autophosphorylation Kinetics and Phosphodonor Preference

(2013) Stephanie A. Thomas et al.   BIOCHEMISTRY

Rational Design of Particle Mesh Ewald Compatible Lennard-Jones Parameters for +2 Metal Cations in Explicit Solvent

(2013) Pengfei Li et al.   Journal of Chemical Theory and Computation

Accurate assessment of mass, models and resolution by small-angle scattering

(2013) Robert P. Rambo et al.   NATURE

Structural Basis of a Rationally Rewired Protein-Protein Interface Critical to Bacterial Signaling

(2013) Anna I. Podgornaia et al.   STRUCTURE

Regulated unfolding: a basic principle of intraprotein signaling in modular proteins

(2013) Joachim E. Schultz et al.   TRENDS IN BIOCHEMICAL SCIENCES

HAMP Domain Conformers That Propagate Opposite Signals in Bacterial Chemoreceptors

(2013) Michael V. Airola et al.   PLOS BIOLOGY

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

Structure–Function Analysis of Arabidopsis thaliana Histidine Kinase AHK5 Bound to Its Cognate Phosphotransfer Protein AHP1

(2012) Johannes Bauer et al.   Molecular Plant

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

An overview of the Amber biomolecular simulation package

(2012) Romelia Salomon-Ferrer et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Genetic and Biochemical Dissection of a HisKA Domain Identifies Residues Required Exclusively for Kinase and Phosphatase Activities

(2012) Jonathan W. Willett et al.   PLoS Genetics

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Biological Phosphoryl-Transfer Reactions: Understanding Mechanism and Catalysis

(2011) Jonathan K. Lassila et al.   Annual Review of Biochemistry

The Residue Threonine 82 of DevR (DosR) Is Essential for DevR Activation and Function in Mycobacterium tuberculosis Despite Its Atypical Location

(2011) U. S. Gautam et al.   JOURNAL OF BACTERIOLOGY

Direct-coupling analysis of residue coevolution captures native contacts across many protein families

(2011) F. Morcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Two-component signaling circuit structure and properties

(2010) Mark Goulian   CURRENT OPINION IN MICROBIOLOGY

Molecular strategies for phosphorylation-mediated regulation of response regulator activity

(2010) Rong Gao et al.   CURRENT OPINION IN MICROBIOLOGY

Applications of the Restriction Free (RF) cloning procedure for molecular manipulations and protein expression

(2010) Tamar Unger et al.   JOURNAL OF STRUCTURAL BIOLOGY

Identical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrate

(2010) Y. Pazy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved mechanism for sensor phosphatase control of two-component signaling revealed in the nitrate sensor NarX

(2010) T. N. Huynh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using Structural Information to Change the Phosphotransfer Specificity of a Two-Component Chemotaxis Signalling Complex

(2010) Christian H. Bell et al.   PLOS BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Biological Insights from Structures of Two-Component Proteins

(2009) Rong Gao et al.   Annual Review of Microbiology

Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction

(2009) Patricia Casino et al.   CELL

Combined sampler robot and high-performance liquid chromatography: a fully automated system for biological small-angle X-ray scattering experiments at the Synchrotron SOLEIL SWING beamline

(2009) G. David et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Structural plasticity and catalysis regulation of a thermosensor histidine kinase

(2009) D. Albanesi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of PAS-Linked Histidine Kinase and the Response Regulator Complex

(2009) Seiji Yamada et al.   STRUCTURE

Macromolecular Modeling with Rosetta

(2008) Rhiju Das et al.   Annual Review of Biochemistry

Rewiring the Specificity of Two-Component Signal Transduction Systems

(2008) Jeffrey M. Skerker et al.   CELL

Determination of Alkali and Halide Monovalent Ion Parameters for Use in Explicitly Solvated Biomolecular Simulations

(2008) In Suk Joung et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Identification of direct residue contacts in protein-protein interaction by message passing

(2008) M. Weigt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A bifunctional kinase-phosphatase in bacterial chemotaxis

(2008) S. L. Porter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Complex between the Phosphorelay Protein YPD1 and the Response Regulator Domain of SLN1 Bound to a Phosphoryl Analog

(2007) Xiaodong Zhao et al.   JOURNAL OF MOLECULAR BIOLOGY