Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification

ABRF Proteome Informatics Research Group (iPRG) 2015 Study: Detection of Differentially Abundant Proteins in Label-Free Quantitative LC–MS/MS Experiments

(2017) Meena Choi et al.   JOURNAL OF PROTEOME RESEARCH

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

(2017) Qian Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

(2017) Annelot C. M. van Esbroeck et al.   SCIENCE

A Whole Proteome Inventory of Background Photocrosslinker Binding

(2016) Philipp Kleiner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding

(2016) Hui Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines

(2016) Yuji Ogura et al.   Nature Chemical Biology

Label-free quantification in ion mobility–enhanced data-independent acquisition proteomics

(2016) Ute Distler et al.   Nature Protocols

Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons

(2015) Marc P. Baggelaar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DIA mass spectrometry

(2015) Allison Doerr   NATURE METHODS

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition

(2015) Daisuke Ogasawara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

(2014) Micah J. Niphakis et al.   Annual Review of Biochemistry

Current Developments in Activity-Based Protein Profiling

(2014) Lianne I. Willems et al.   BIOCONJUGATE CHEMISTRY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Isobaric Labeling-Based Relative Quantification in Shotgun Proteomics

(2014) Navin Rauniyar et al.   JOURNAL OF PROTEOME RESEARCH

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Shedding light on black boxes in protein identification

(2014) Marc Vaudel et al.   PROTEOMICS

Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-α in Brain

(2013) Marc P. Baggelaar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving Qualitative and Quantitative Performance for MSE-based Label-free Proteomics

(2013) Nicholas J. Bond et al.   JOURNAL OF PROTEOME RESEARCH

Determining target engagement in living systems

(2013) Gabriel M Simon et al.   Nature Chemical Biology

Target validation using chemical probes

(2013) Mark E Bunnage et al.   Nature Chemical Biology

Drift time-specific collision energies enable deep-coverage data-independent acquisition proteomics

(2013) Ute Distler et al.   NATURE METHODS

Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS

(2013) Nan Li et al.   Nature Protocols

Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present

(2012) Marcus Bantscheff et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

To label or not to label: Applications of quantitative proteomics in neuroscience research

(2012) Michaela D. Filiou et al.   PROTEOMICS

Less label, more free: Approaches in label-free quantitative mass spectrometry

(2011) Karlie A. Neilson et al.   PROTEOMICS

An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies

(2009) Erin Shammel Baker et al.   JOURNAL OF PROTEOME RESEARCH

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry