Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH
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Title
Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH
Authors
Keywords
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Journal
EMBO REPORTS
Volume 12, Issue 12, Pages 1300-1305
Publisher
Wiley
Online
2011-11-12
DOI
10.1038/embor.2011.205
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- Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease
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- Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor
- (2009) Sha Huang et al. JOURNAL OF LIPID RESEARCH
- Model of human low-density lipoprotein and bound receptor based on CryoEM
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- Update and Analysis of the University College London Low Density Lipoprotein Receptor Familial Hypercholesterolemia Database
- (2008) S. E. A. Leigh et al. ANNALS OF HUMAN GENETICS
- The Epidermal Growth Factor Homology Domain of the LDL Receptor Drives Lipoprotein Release through an Allosteric Mechanism Involving H190, H562, and H586
- (2008) Zhenze Zhao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanism of Low Density Lipoprotein (LDL) Release in the Endosome
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- Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants
- (2008) Matthew J. Bottomley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Annexin A2 Is a C-terminal PCSK9-binding Protein That Regulates Endogenous Low Density Lipoprotein Receptor Levels
- (2008) Gaétan Mayer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PCSK9: a convertase that coordinates LDL catabolism
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- Molecular basis for LDL receptor recognition by PCSK9
- (2008) H. J. Kwon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
- (2008) D.-W. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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