Metabolic engineering of a carbapenem antibiotic synthesis pathway in Escherichia coli

Stereoselective Production of Dimethyl-Substituted Carbapenams via Engineered Carbapenem Biosynthesis Enzymes

(2017) Refaat B. Hamed et al.   ACS Catalysis

Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated ‘Entotheonella’ bacteria

(2016) Michael F Freeman et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Engineering a functional 1-deoxy-D-xylulose 5-phosphate (DXP) pathway in Saccharomyces cerevisiae

(2016) James Kirby et al.   METABOLIC ENGINEERING

Engineering microbial hosts for production of bacterial natural products

(2016) Mingzi M. Zhang et al.   NATURAL PRODUCT REPORTS

Genetically encoded sensors enable real-time observation of metabolite production

(2016) Jameson K. Rogers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A self-inducible heterologous protein expression system in Escherichia coli

(2016) L. Briand et al.   Scientific Reports

Regulating malonyl-CoA metabolism via synthetic antisense RNAs for enhanced biosynthesis of natural products

(2015) Yaping Yang et al.   METABOLIC ENGINEERING

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

(2015) Peter J. Rutledge et al.   NATURE REVIEWS MICROBIOLOGY

Consecutive radicalS-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

(2015) Daniel R. Marous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tunable protein degradation in bacteria

(2014) D Ewen Cameron et al.   NATURE BIOTECHNOLOGY

Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

(2014) W.-c. Chang et al.   SCIENCE

HipA-Triggered Growth Arrest and  -Lactam Tolerance in Escherichia coli Are Mediated by RelA-Dependent ppGpp Synthesis

(2013) G. Bokinsky et al.   JOURNAL OF BACTERIOLOGY

Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus

(2013) Daniel Zabala et al.   METABOLIC ENGINEERING

Antibiotic resistance: The last resort

(2013) Maryn McKenna   NATURE

Biochemical Similarities and Differences between the Catalytic [4Fe-4S] Cluster Containing Fumarases FumA and FumB from Escherichia coli

(2013) Barbara M. A. van Vugt-Lussenburg et al.   PLoS One

The enzymes of β-lactam biosynthesis

(2012) Refaat B. Hamed et al.   NATURAL PRODUCT REPORTS

Carbapenems: Past, Present, and Future

(2011) Krisztina M. Papp-Wallace et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Amino Acid Precursor Supply in the Biosynthesis of the RNA Polymerase Inhibitor Streptolydigin by Streptomyces lydicus

(2011) C. Gomez et al.   JOURNAL OF BACTERIOLOGY

Complete Biosynthesis of Erythromycin A and Designed Analogs Using E. coli as a Heterologous Host

(2010) Haoran Zhang et al.   CHEMISTRY & BIOLOGY

Molecular Mechanisms Modulating Glutamate Kinase Activity. Identification of the Proline Feedback Inhibitor Binding Site

(2010) Isabel Pérez-Arellano et al.   JOURNAL OF MOLECULAR BIOLOGY

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

(2010) Marnix H. Medema et al.   NATURE REVIEWS MICROBIOLOGY

Metagenomic approaches to natural products from free-living and symbiotic organisms

(2009) Sean F. Brady et al.   NATURAL PRODUCT REPORTS

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

(2008) Carlos Olano et al.   METABOLIC ENGINEERING